LPAR1

Lysophosphatidic acid receptor 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4Z34, 4Z35, 4Z36
Identifiers
Symbols	LPAR1 ; EDG2; GPR26; Gpcr26; LPA1; Mrec1.3; VZG1; edg-2; rec.1.3; vzg-1
External IDs	OMIM: 602282 MGI: 108429 HomoloGene: 1072 IUPHAR: 272 ChEMBL: 3819 GeneCards: LPAR1 Gene
Gene ontology Molecular function • G-protein alpha-subunit binding • G-protein coupled receptor activity • protein binding • PDZ domain binding • lysophosphatidic acid binding • lysophosphatidic acid receptor activity Cellular component • endosome • cytosol • plasma membrane • integral component of plasma membrane • cell surface • endocytic vesicle • dendritic spine • dendritic shaft Biological process • activation of MAPK activity • G-protein coupled receptor signaling pathway • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • activation of phospholipase C activity • positive regulation of cytosolic calcium ion concentration • regulation of cell shape • negative regulation of neuron projection development • bleb assembly • positive regulation of Rho protein signal transduction • myelination • positive regulation of apoptotic process • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of MAPK cascade • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway • positive regulation of stress fiber assembly • cell chemotaxis • positive regulation of dendritic spine development • cellular response to oxygen levels • positive regulation of smooth muscle cell chemotaxis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1902	14745
Ensembl	ENSG00000198121	ENSMUSG00000038668
UniProt	Q92633	P61793
RefSeq (mRNA)	NM_001401	NM_001290486
RefSeq (protein)	NP_001392	NP_001277415
Location (UCSC)	Chr 9: 110.87 – 111.04 Mb	Chr 4: 58.44 – 58.55 Mb
PubMed search	[1]	[2]

Lysophosphatidic acid receptor 1 also known as LPA₁ is a protein that in humans is encoded by the LPAR1 gene. LPA₁ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

Function

The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Alternative splicing of this gene has been observed and two transcript variants have been described, each encoding identical proteins. An alternate translation start codon has been identified, which results in isoforms differing in the N-terminal extracellular tail. In addition, an alternate polyadenylation site has been reported.

See also

• Lysophospholipid receptor

Further reading

• An S, Goetzl EJ, Lee H (1999). "Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate.". J. Cell. Biochem. Suppl. 30-31: 147–57. PMID 9893266. 
• Contos JJ, Ishii I, Chun J (2001). "Lysophosphatidic acid receptors.". Mol. Pharmacol. 58 (6): 1188–96. PMID 11093753. 
• Moolenaar WH, Kranenburg O, Postma FR, Zondag GC (1997). "Lysophosphatidic acid: G-protein signalling and cellular responses.". Curr. Opin. Cell Biol. 9 (2): 168–73. doi:10.1016/S0955-0674(97)80059-2. PMID 9069262. 
• Fukushima N, Kimura Y, Chun J (1998). "A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid.". Proc. Natl. Acad. Sci. U.S.A. 95 (11): 6151–6. doi:10.1073/pnas.95.11.6151. PMC 27607. PMID 9600933. 
• An S, Bleu T, Zheng Y, Goetzl EJ (1998). "Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization.". Mol. Pharmacol. 54 (5): 881–8. PMID 9804623. 
• Cervera P, Tirard M, Barron S, et al. (2002). "Immunohistological localization of the myelinating cell-specific receptor LP(A1).". Glia 38 (2): 126–36. doi:10.1002/glia.10054. PMID 11948806. 
• Hama K, Bandoh K, Kakehi Y, et al. (2002). "Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors.". FEBS Lett. 523 (1-3): 187–92. doi:10.1016/S0014-5793(02)02976-9. PMID 12123830. 
• Van Leeuwen FN, Olivo C, Grivell S, et al. (2003). "Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1.". J. Biol. Chem. 278 (1): 400–6. doi:10.1074/jbc.M210151200. PMID 12393875. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Murph MM, Scaccia LA, Volpicelli LA, Radhakrishna H (2004). "Agonist-induced endocytosis of lysophosphatidic acid-coupled LPA1/EDG-2 receptors via a dynamin2- and Rab5-dependent pathway.". J. Cell. Sci. 116 (Pt 10): 1969–80. doi:10.1242/jcs.00397. PMID 12668728. 
• Shida D, Kitayama J, Yamaguchi H, et al. (2003). "Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1.". Cancer Res. 63 (7): 1706–11. PMID 12670925. 
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. 
• Xu J, Lai YJ, Lin WC, Lin FT (2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor.". J. Biol. Chem. 279 (11): 10459–68. doi:10.1074/jbc.M311891200. PMID 14688263. 
• Komuro Y, Watanabe T, Kitayama J, et al. (2004). "The Immunohistochemical expression of endothelial cell differentiation gene-2 receptor in human colorectal adenomas.". Hepatogastroenterology 50 (54): 1770–3. PMID 14696401. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Kaneider NC, Lindner J, Feistritzer C, et al. (2005). "The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor.". FASEB J. 18 (11): 1309–11. doi:10.1096/fj.03-1050fje. PMID 15208267. 

External links

• "Lysophospholipid Receptors: LPA₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
• Lysophospholipid receptors at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.