Diethylene dioxide; Diox 1,4-Dioxane dictionary

1,4-Dioxane

Synonyms: Diethylene dioxide; Diox

Name: 1,4-Dioxane
Molecular Formula: C4H8O2
Hazard Symbols: F:Flammable
Molecular Structure:
Usage:
CAS: 123-91-1
Analytical:
Density: 1.033
Analytical:
Packinggroup: II
Specification:
Transport: UN 1165
EINECS: 204-661-8
Chemical Properties:
Sensitive: Hygroscopic
Molecular Weight: 88.11
Hazard Classification: 3
Water Solubility: SOLUBLE
Solubility: Soluble in water
Refractive index: 1.4205-1.422
Appearance: Colorless clear liquid
Safety Statements: S16;S36/37;S46;S9
Storage Temperature: Flammables area
Risk Statements: R11;R19;R36/37;R40;R66
InChI: InChI=1/C4H8O2/c1-2-6-4-3-5-1/h1-4H2
Color: Colorless liquid or solid (below 53 degrees F).
Stability: Stable. Incompatible with oxidizing agents, oxygen, halogens, reducing agents, moisture. Highly flammable - note wide explosive range. May form explosive peroxides in storage (rate of formation increased by heating, evaporation or exposure to light).
Report:
NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2B IMEMDT ?? IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 201.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.:?) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT ?? IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 11 , 1976,p. 247.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.:?) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Bioassay (oral); Clear Evidence: mouse, rat NCITR* ?? National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-80 ,1978. . EPA Genetic Toxicology Program. Glycol ether compounds are on the Community Right-To-Know List. Reported in EPA TSCA Inventory.

Toxicity:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LCLo	inhalation	44gm/m3/7H (44000mg/m3)	BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: DYSPNEA	"Beitrag zur Toxikologischen Wirkung Technischer Losungsmittel, Dissertation," Klimmer, O., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1937Vol. -, Pg. -, 1937.
cat	LD50	oral	2gm/kg (2000mg/kg)	?	Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 173, 1939.
cat	LDLo	intravenous	1500mg/kg (1500mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: IRRITABILITY	Journal of Hygiene. Vol. 35, Pg. 540, 1935.
guinea pig	LD50	oral	3150mg/kg (3150mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC KIDNEY, URETER, AND BLADDER: OTHER CHANGES GASTROINTESTINAL: OTHER CHANGES	Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.
human	LCLo	inhalation	470ppm/3D (470ppm)	BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LIVER: OTHER CHANGES	Pollution Engineering. Vol. 7(9), Pg. 22, 1975.
human	TCLo	inhalation	470ppm (470ppm)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION GASTROINTESTINAL: OTHER CHANGES	AMA Archives of Industrial Health. Vol. 20, Pg. 445, 1959.
human	TCLo	inhalation	5500ppm/1M (5500ppm)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Public Health Reports. Vol. 45, Pg. 2023, 1930.
mammal (species unspecified)	LC50	inhalation	20500mg/m3 (20500mg/m3)	?	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 51(5), Pg. 61, 1986.
mouse	LC50	inhalation	37gm/m3/2H (37000mg/m3)	?	"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 63, 1982.
mouse	LD50	intraperitoneal	790mg/kg (790mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 6, Pg. 342, 1947.
mouse	LD50	oral	5300mg/kg (5300mg/kg)	?	Indian Journal of Experimental Biology. Vol. 16, Pg. 54, 1978.
rabbit	LD50	oral	2gm/kg (2000mg/kg)	?	Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 173, 1939.
rabbit	LD50	skin	7600uL/kg (7.6mL/kg)	?	Union Carbide Data Sheet. Vol. 12/17/1971,
rabbit	LDLo	intravenous	1500mg/kg (1500mg/kg)	KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED	Journal of Hygiene. Vol. 35, Pg. 540, 1935.
rat	LC50	inhalation	46gm/m3/2H (46000mg/m3)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE	Kosmicheskaya Biologiya I Aviakosmicheskaya Meditsina. Space Biology and Aerospace Medicine. Vol. 11(6), Pg. 53, 1977.
rat	LD50	intraperitoneal	799mg/kg (799mg/kg)	?	Environmental Research. Vol. 40, Pg. 411, 1986.
rat	LD50	oral	4200mg/kg (4200mg/kg)	?	Industrial Health. Vol. 32, Pg. 145, 1994.