The 49ers and Broncos meet for the first time since a London game nearly four years ago, when neither team was the powerhouse it has become. Now it is a potential Super Bowl preview.
Peyton Manning needs three TD passes to break Brett Favre's mark (508). He's averaging three a game this season.
"It's not something we talk about as an offense," said tight end Julius Thomas, who already has nine TD catches. "Peyton doesn't talk about it. We just keep playing football."
The Niners started 1-2, but have begun to play some impressive football, too. They understand the chore ahead in trying to stop Manning.
"Whenever he takes the field, he's just great all the time and that speaks volumes for the player that he is and continues to be," 49ers coach Jim Harbaugh said. "Just keeps doing it and doing it and doing it. Great. Great with a capital 'G' at the highest level."