Zika virus (ATCC® VR-84)

Classification: Flaviviridae, Flavivirus  /  Product Format: freeze-dried

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Classification Flaviviridae, Flavivirus
Agent Zika virus
Strain MR 766 (Original)
Biosafety Level 2

Biosafety  classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.

Product Format freeze-dried
Storage Conditions -70°C or colder

The depositor reports that ATCC® VR-84™ can agglutinate goose and chicken RBC, and that this strain is non-pathogenic for hamster, guinea pig, or rabbit. 

Accidental infection has occurred in laboratory personnel

The lyophilized culture is stable at 4°C, and should be stored at -70°C or colder once rehydrated
Effect on Host
Paralysis and death
Recommended Host
Suckling mouse
Growth Conditions Recommendations for Infection: Inoculate intracerebrally into suckling mice.  Resuspend 20% sMb with 7.5% BSA in PBS.
Incubation: 5-7 days
Effect on Host
Paralysis and death
Name of Depositor J. Casals, Rockefeller Foundation
Source Blood from experimental forest sentinel rhesus monkey, Uganda, 1947
Year of Origin 1947

Dick GW, Kitchen SF, and Haddow AJ. Zika Virus. I. Isolations and Serological Specificity. Trans R Soc Trop Med Hyg 46: 509-520, 1952. PubMed: 12995440

Zhu Z, et al. Comparative genomic analysis of pre-epidemic and epidemic Zika virus strains for virological factors potentially associated with the rapidly expanding epidemic. Emerg Microbes Infect 5: e22, 2016.

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Basic Documentation
  1. What is Zika virus
    Zika virus is a single-stranded RNA virus of the Flaviviridae family, genus Flavivirus (which also includes the Dengue, and West Nile Viruses). Zika virus is transmitted to humans primarily ...

    Date Updated: 3/3/2016
  2. Is Zika a new virus
    No. According to the CDC, Zika previously has been reported in tropical Africa, Southeast Asia, and the Pacific Islands. In May 2015, the Pan American Health Organization (PAHO) issued an alert r...
    Date Updated: 2/5/2016
  3. Does ATCC distribute the Zika virus
    Yes, Zika virus (ATCC® VR-84™) strain MR766 has been distributed by ATCC since 1953.  The virus is available through ATCC, and our designated

    Date Updated: 3/1/2016
  4. Source of VR-84 Zika
    The virus was deposited into ATCC by Dr. Jordi Casals of the Rockefeller Foundation Virus Laboratory in 1953. The original source was isolated in 1947 from the blood of an experimental forest sen...
    Date Updated: 2/5/2016
  5. Obtaining Zika
    Zika virus is classified as a biological safety level (BSL) 2 pathogen. In order to request Zika virus from ATCC, requestors and their institutions must demonstrate they have appropriate faciliti...
    Date Updated: 2/5/2016
  6. Safety of Zika shipments

    All ATCC shipments meet all domestic and global regulatory requirements for packaging, labeling and shipping of hazardous biological materials. 

    Date Updated: 2/5/2016
  7. Current sources of Zika

    Yes.  The Zika virus is also available through the following sources:

    Date Updated: 2/5/2016