Neuropeptide Y receptor Y2

Neuropeptide Y receptor Y2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2IK3​
Identifiers
Symbols	NPY2R ; NPY2-R
External IDs	OMIM: 162642 MGI: 108418 HomoloGene: 701 IUPHAR: 306 ChEMBL: 4018 GeneCards: NPY2R Gene
Gene ontology Molecular function • peptide YY receptor activity • receptor activity • neuropeptide Y receptor activity • calcium channel regulator activity • protein binding Cellular component • cytosol • plasma membrane • integral component of plasma membrane • nonmotile primary cilium Biological process • behavioral fear response • positive regulation of peptide secretion • outflow tract morphogenesis • cardiac left ventricle morphogenesis • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • positive regulation of cytosolic calcium ion concentration • neuropeptide signaling pathway • nitric oxide mediated signal transduction • locomotory behavior • positive regulation of cell-substrate adhesion • negative regulation of cAMP biosynthetic process • negative regulation of neurological system process • positive regulation of dopamine secretion • positive regulation of smooth muscle contraction • positive regulation of circadian sleep/wake cycle, non-REM sleep • secretion • negative regulation of secretion • regulation of sensory perception of pain • negative regulation of synaptic transmission, glutamatergic • negative regulation of excitatory postsynaptic potential • negative regulation of feeding behavior Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4887	18167
Ensembl	ENSG00000185149	ENSMUSG00000028004
UniProt	P49146	P97295
RefSeq (mRNA)	NM_000910	NM_001205099
RefSeq (protein)	NP_000901	NP_001192028
Location (UCSC)	Chr 4: 155.21 – 155.22 Mb	Chr 3: 82.54 – 82.55 Mb
PubMed search	[1]	[2]

Neuropeptide Y receptor type 2 (Y2R) is a protein that in humans is encoded by the NPY2R gene.

Selective ligands

Agonists

• Neuropeptide Y (endogenous agonist, non subtype selective)
• Neuropeptide Y fragment 13-36 (NPY₂ selective agonist)
• 2-Thiouridine 5'-triphosphate (CAS# 35763-29-2)
• Peptide YY
• Peptide YY 3-36 fragment

Antagonists

• BIIE-0246 (CAS# 246146-55-4)
• JNJ 5207787 (CAS# 683746-68-1)
• SF 11 (CAS# 443292-81-7)

See also

• Neuropeptide Y receptor

External links

• "Neuropeptide Y Receptors: Y₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

• Wan CP, Lau BH (Feb 1995). "Neuropeptide Y receptor subtypes". Life Sciences 56 (13): 1055–64. doi:10.1016/0024-3205(95)00041-4. PMID 9001438. 
• Parker E, Van Heek M, Stamford A (Apr 2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status". European Journal of Pharmacology 440 (2-3): 173–87. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534. 
• Herzog H, Hort YJ, Ball HJ, Hayes G, Shine J, Selbie LA (Jul 1992). "Cloned human neuropeptide Y receptor couples to two different second messenger systems". Proceedings of the National Academy of Sciences of the United States of America 89 (13): 5794–8. doi:10.1073/pnas.89.13.5794. PMC: 402104. PMID 1321422. 
• Gerald C, Walker MW, Vaysse PJ, He C, Branchek TA, Weinshank RL (Nov 1995). "Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype". The Journal of Biological Chemistry 270 (45): 26758–61. doi:10.1074/jbc.270.45.26758. PMID 7592910. 
• Lynch JW, Lemos VS, Bucher B, Stoclet JC, Takeda K (Mar 1994). "A pertussis toxin-insensitive calcium influx mediated by neuropeptide Y2 receptors in a human neuroblastoma cell line". The Journal of Biological Chemistry 269 (11): 8226–33. PMID 8132547. 
• Gehlert DR, Beavers LS, Johnson D, Gackenheimer SL, Schober DA, Gadski RA (Feb 1996). "Expression cloning of a human brain neuropeptide Y Y2 receptor". Molecular Pharmacology 49 (2): 224–8. PMID 8632753. 
• Yan H, Yang J, Marasco J, Yamaguchi K, Brenner S, Collins F, Karbon W (May 1996). "Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors". Proceedings of the National Academy of Sciences of the United States of America 93 (10): 4661–5. doi:10.1073/pnas.93.10.4661. PMC: 39335. PMID 8643460. 
• Ammar DA, Eadie DM, Wong DJ, Ma YY, Kolakowski LF, Yang-Feng TL, Thompson DA (Dec 1996). "Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene". Genomics 38 (3): 392–8. doi:10.1006/geno.1996.0642. PMID 8975716. 
• Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP (Jul 1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". The Journal of Biological Chemistry 273 (28): 17749–55. doi:10.1074/jbc.273.28.17749. PMID 9651375. 
• Caberlotto L, Fuxe K, Rimland JM, Sedvall G, Hurd YL (Sep 1998). "Regional distribution of neuropeptide Y Y2 receptor messenger RNA in the human post mortem brain". Neuroscience 86 (1): 167–78. doi:10.1016/S0306-4522(98)00039-6. PMID 9692752. 
• Goumain M, Voisin T, Lorinet AM, Ducroc R, Tsocas A, Rozé C, Rouet-Benzineb P, Herzog H, Balasubramaniam A, Laburthe M (Jul 2001). "The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning". Molecular Pharmacology 60 (1): 124–34. PMID 11408607. 
• Cox HM, Tough IR (Mar 2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa". British Journal of Pharmacology 135 (6): 1505–12. doi:10.1038/sj.bjp.0704604. PMC: 1573267. PMID 11906964. 
• Uddman R, Möller S, Nilsson T, Nyström S, Ekstrand J, Edvinsson L (May 2002). "Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues". Peptides 23 (5): 927–34. doi:10.1016/S0196-9781(02)00003-7. PMID 12084524. 
• Hyland NP, Sjöberg F, Tough IR, Herzog H, Cox HM (Jun 2003). "Functional consequences of neuropeptide Y Y 2 receptor knockout and Y2 antagonism in mouse and human colonic tissues". British Journal of Pharmacology 139 (4): 863–71. doi:10.1038/sj.bjp.0705298. PMC: 1573894. PMID 12813010. 
• Hung CC, Pirie F, Luan J, Lank E, Motala A, Yeo GS, Keogh JM, Wareham NJ, O'Rahilly S, Farooqi IS (Sep 2004). "Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits". Diabetes 53 (9): 2461–6. doi:10.2337/diabetes.53.9.2461. PMID 15331560.