The Rutgers Transdisciplinary Prevention Research Center (RTPRC), funded by NIDA, focused on developing methods of intervention during a student’s key developmental transitional periods. The Center included established investigators representing a wide range of scientific disciplines and specialties from the core, joint and visiting faculty of the CAS, noted investigators from two other established research programs, and prevention partners. The broad focus and goal of RTPRC was acquisition of knowledge about the manner in which individuals, transitioning key developmental phases (including turning points in drug use staging), acquire and integrate information about substance use behavior into their behavioral repertoire and the application of that knowledge in the design of prevention interventions. The RTPRC was organized around two cores (Administrative and Resource) and three project areas. The Project areas were: (1) Enhanced peer-based interventions during the transition to high school; (2) Developing brief interventions for drug abuse prevention for college students; and (3) Memory processes emotional regulation and developmental stage of drug exposure. Project Cores and Projects were multidisciplinary and spanned the range of drug abuse prevention research.