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Original Investigation | August 29, 2016 ONLINE FIRST
GBA Mutations and the E326K Polymorphism in Parkinson Disease
This cohort study examines the association of GBA mutations and E326K polymorphisms with progression of motor symptoms and cognitive decline in patients with Parkinson disease.
Original Investigation | August 22, 2016 ONLINE FIRST
Tau Deposition and Cognitive Decline in Patients With Non-Alzheimer Pathophysiology
This cohort study assesses PET-measured tau deposition and cognitive decline over 5 years in Harvard Aging Brain study participants who were beta-amyloid-negative with neurodegeneration at baseline. Editorial
Original Investigation | August 15, 2016 ONLINE FIRST
Association Between CV Risk Factors and Familial Alzheimer Disease
This cohort study investigates associations between coronary risk factors, stroke, and late-onset Alzheimer dementia in patients with familial disease.
Original Investigation | August 8, 2016 ONLINE FIRST
Serum Docosahexaenoic Acid and Cerebral Amyloidosis
This cross-sectional study investigates correlations between serum DHA levels and cerebral amyloidosis, brain volumes, and neuropsychological testing measures in Aging Brain Study participants. Editorial
Clinical Implications of Basic Neuroscience Research | August 1, 2016 ONLINE FIRST
Antisense Oligonucleotide Treatment of Neurological Disease
This narrative review summarizes the evolution of antisense oligonucleotides for treatment of neurological disorders. Editorial
Author Interview
Interview with Paul K. Crane, MD, MPH, author of Association of Traumatic Brain Injury With Late-Life Neurodegenerative Conditions and Neuropathologic Findings
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Article Video
Episodic Dystonia (0:24)
Video EEG recording showing a typical event consisting of a rapid dystonia involving the right arm and associated with the patient’s described cycling auras.
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Oncology
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A Young Man With Recurrent Coma and Refractory Status Epilepticus
A man in his 30s presented with a 5-day history of vomiting, followed by lethargy and confusion. Two years prior, he had been hospitalized with coma with no identifiable precipitant.
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