Frederick lab using new high-tech microscopes in cancer research
The New Electron Microscopy: Cells and Molecules in Three Dimensions
Through the High-Tech Looking Glass


The Center for Molecular Microscopy (CMM) is an organization aimed at developing new techniques and technologies for high resolution imaging by electron microscopy in 3D.

CMM is divided into two distinct components: a CCR collaboratory component, where researchers can work with CMM on important problems arising primarily from the CCR portfolio that are well-suited to CMM capabilities, and a technology development component with special focus on RAS structural and cell biology and related topics in membrane signaling.

The collaboratory component of the CMM is designed to use emerging tools in 3D electron microscopy to undertake biological research relevant to NCI/NIH mission. The collaboratory is overseen by the CMM Advisory Panel, appointed by CCR leadership.

The technology development/membrane signaling component of CMM is a direct collaboration with the Subramaniam laboratory and the Frederick National Laboratory RAS Initiative, and includes both a biological focus on RAS structural biology and the technological developments necessary to address this problem at the structural and cellular level.

Work carried out by the CMM is supported by instrumentation at the Advanced Technology Research Facility in Frederick, MD. If you are interested in collaborating with us as part of the CMM Collaboratory, please submit a research proposal or contact us directly.


The goal of the Center for Molecular Microscopy (CMM) is to apply emerging technologies for 3D electron microscopy to problems of fundamental interest in cancer and HIV/AIDS biology.

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Our research program primarily focuses on the use of electron microscopic techniques to acquire and analyze high resolution structures of molecules, cells and tissues in 3D at high resolution.

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