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Cyclizine Side Effects

For the Consumer

Applies to cyclizine: oral tablet, oral tablet chewable

Get emergency medical help if you have any of these signs of an allergic reaction while taking cyclizine: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using cyclizine and call your doctor at once if you have:

  • painful or difficult urination;

  • little or no urinating;

  • pounding heartbeats or fluttering in your chest; or

  • a light-headed feeling, like you might pass out.

Common side effects may include:

  • drowsiness, weakness, loss of coordination;

  • nausea, dry mouth, constipation; or

  • blurred vision.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to cyclizine: oral tablet, oral tablet chewable

Nervous system

Nervous system side effects have included drowsiness and sedation in many patients. Motor skills may be impaired. Cyclizine may also cause restlessness, excitation, nervousness, and insomnia.[Ref]

Lingual-facial-buccal dyskinesias and generalized chorea occurred in an elderly patient, most probably due to the anticholinergic activity of cyclizine.[Ref]


Cardiovascular side effects have included hypotension, tachycardia, and palpitations. Cardiovascular changes recorded after intravenous administration of cyclizine have included increase in heart rate, decrease in cardiac output, and increases in right atrial, pulmonary arterial, pulmonary artery wedge, and systemic arterial pressures.[Ref]


Gastrointestinal side effects have been mild in nature. These have included nausea, dry mouth, and constipation.[Ref]


Ocular side effects have included blurred vision, diplopia, and dry eyes due to its anticholinergic effects.[Ref]


Genitourinary side effects have included urinary retention and dysuria.[Ref]


Hepatic side effects have included a case report of hepatitis in at least one child. This side effect was confirmed upon drug rechallenge.[Ref]


Hypersensitivity side effects have included fixed drug eruptions.[Ref]


1. Klawans HL, Moskovitz C "Cyclizine-induced chorea. Observations on the influence of cyclizine on dopamine-related movement disorders." J Neurol Sci 31 (1977): 237-44

2. "Product Information. Marezine (cyclizine)." Glaxo Wellcome, Research Triangle Park, NC.

3. Kew MC, Segel J, Zoutendyk A ""Hypersensitivity hepatitis" associated with administration of cyclizine." Br Med J 2 (1973): 307

4. Griffiths WA, Peachey RD "Fixed drug eruption due to cyclizine." Br J Dermatol 82 (1970): 616-7

Not all side effects for cyclizine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.