High-Performance Computing at the NIH
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The NIH HPC group plans, manages and supports high-performance computing systems specifically for the intramural NIH community. These systems include Biowulf, a 60,000+ processor Linux cluster; Helix, an interactive system for short jobs, Sciware, a set of applications for desktops, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

Recent Papers that used Biowulf & HPC Resources

thumbnail image from paper Towards understanding the structural basis of partial agonism at the dopamine D3 receptor
Michino, M; Boateng, CA; Donthamsetti, P et al.
J. Med. Chem. , DOI://10.1021/acs.jmedchem.6b01148 (2016)

thumbnail image from paper Lipid and Peptide Diffusion in Bilayers: The Saffman-Delbr├╝ck Model and Periodic Boundary Conditions
Venable, RM; Ing├│lfsson, HI; Lerner, MG et al.
J Phys Chem B , DOI://10.1021/acs.jpcb.6b09111 (2016)

thumbnail image from paper DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases
Ligthart, S; Marzi, C; Aslibekyan, S et al.
Genome Biol. , DOI://10.1186/s13059-016-1119-5 (2016)

thumbnail image from paper Structure-Based Scaffold Repurposing for G Protein-Coupled Receptors: Transformation of Adenosine Derivatives into 5HT2B/5HT2C Serotonin Receptor Antagonists
Tosh, DK; Ciancetta, A; Warnick, E; Crane, S; Gao, ZG; Jacobson, KA;
J. Med. Chem. , DOI://10.1021/acs.jmedchem.6b01183 (2016)

thumbnail image from paper Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications
Ombrello, MJ; Arthur, VL; Remmers, EF et al.
Ann. Rheum. Dis. , DOI://10.1136/annrheumdis-2016-210324 (2016)

thumbnail image from paper Somatic Genomics and Clinical Features of Lung Adenocarcinoma: A Retrospective Study
Shi, J; Hua, X; Zhu, B et al.
PLoS Med. , DOI://10.1371/journal.pmed.1002162 (2016)

thumbnail image from paper Mapping Complex Traits in a Diversity Outbred F1 Mouse Population Identifies Germline Modifiers of Metastasis in Human Prostate Cancer
Winter, JM; Gildea, DE; Andreas, JP et al.
Cell Syst , DOI://10.1016/j.cels.2016.10.018 (2016)

thumbnail image from paper Sparse multidimensional iterative lineshape-enhanced (SMILE) reconstruction of both non-uniformly sampled and conventional NMR data
Ying, J; Delaglio, F; Torchia, DA; Bax, A;
J. Biomol. NMR , DOI://10.1007/s10858-016-0072-7 (2016)