OR12D2

Functionⁱ

Odorant receptor.Curated

Enzyme and pathway databases

BioCycⁱ	ZFISH:ENSG00000168787-MONOMER.
Reactomeⁱ	R-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Olfactory receptor 12D2 Alternative name(s): Hs6M1-20 Olfactory receptor OR6-28
Gene namesⁱ	Name:OR12D2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

HGNCⁱ	HGNC:8178. OR12D2.

HGNCⁱ

HGNC:8178. OR12D2.

Subcellular locationⁱ

Cell membrane; Multi-pass membrane protein

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 23	ExtracellularSequence analysisAdd BLAST	23
Transmembraneⁱ	24 – 44	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	45 – 52	CytoplasmicSequence analysis	8
Transmembraneⁱ	53 – 73	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	74 – 97	ExtracellularSequence analysisAdd BLAST	24
Transmembraneⁱ	98 – 118	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	119 – 137	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	138 – 158	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	159 – 195	ExtracellularSequence analysisAdd BLAST	37
Transmembraneⁱ	196 – 215	Helical; Name=5Sequence analysisAdd BLAST	20
Topological domainⁱ	216 – 236	CytoplasmicSequence analysisAdd BLAST	21
Transmembraneⁱ	237 – 257	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	258 – 270	ExtracellularSequence analysisAdd BLAST	13
Transmembraneⁱ	271 – 291	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	292 – 307	CytoplasmicSequence analysisAdd BLAST	16

GO - Cellular componentⁱ

integral component of membrane Source: GO_Central
plasma membrane Source: Reactome

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNETⁱ	26529.
OpenTargetsⁱ	ENSG00000280236.
PharmGKBⁱ	PA32028.

Polymorphism and mutation databases

BioMutaⁱ	OR12D2.
DMDMⁱ	288558820.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000150728	1 – 307	Olfactory receptor 12D2Add BLAST		307

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	3	N-linked (GlcNAc...)Sequence analysis		1
Disulfide bondⁱ	95 ↔ 187	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P58182.
PeptideAtlasⁱ	P58182.
PRIDEⁱ	P58182.

PTM databases

iPTMnetⁱ	P58182.
PhosphoSitePlusⁱ	P58182.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000168787.
CleanExⁱ	HS_OR12D2.
ExpressionAtlasⁱ	P58182. baseline and differential.
Genevisibleⁱ	P58182. HS.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P58182.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IH3D. Eukaryota. ENOG410YBP5. LUCA.
GeneTreeⁱ	ENSGT00390000018942.
HOGENOMⁱ	HOG000041362.
HOVERGENⁱ	HBG017625.
InParanoidⁱ	P58182.
KOⁱ	K04257.
OMAⁱ	LACENTE.
OrthoDBⁱ	EOG091G0CKO.
PhylomeDBⁱ	P58182.
TreeFamⁱ	TF338273.

Family and domain databases

InterProⁱ	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTSⁱ	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITEⁱ	PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]

Sequenceⁱ

Sequence statusⁱ: Complete.

P58182-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLNTTSVTEF LLLGVTDIQE LQPFLFVVFL TIYFISVTGN GAVLMIVISD 
        60         70         80         90        100
PRLHSLMYFF LGNLSYLDIC YSTVTLPKML QNFLSTHKAI SFLGCISQLH 
       110        120        130        140        150
FFHSLGSTES MLFAVMAFDL SVAICKPLRY TVIMNPQLCT QMAITIWVIG 
       160        170        180        190        200
FFHALLHSVM TSRLNFCGSN RIHHFLCDIK PLLKLACGNT ELNQWLLSTV 
       210        220        230        240        250
TGTIAMGPFF LTLLSYFYII TYLFFKTRSC SMLCKALSTC ASHFMVVILF 
       260        270        280        290        300
YAPVLFTYIH PALESFMDQD RIVAIMYTVV TPVLNPLIYT LRNKEVKGAL 

GRVIRRL

Length:307

Mass (Da):34,813

Last modified:February 9, 2010 - v2

Checksum:ⁱ982907668FCFDE8A

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_057569	47	V → F.Corresponds to variant rs9257834dbSNPEnsembl.	1
Natural variantⁱVAR_057570	56	L → P.Corresponds to variant rs4987411dbSNPEnsembl.	1
Natural variantⁱVAR_058967	104	S → F.4 PublicationsCorresponds to variant rs3128853dbSNPEnsembl.	1
Natural variantⁱVAR_057571	113	F → L.Corresponds to variant rs2073154dbSNPEnsembl.	1
Natural variantⁱVAR_057572	120	L → R.Corresponds to variant rs2073153dbSNPEnsembl.	1
Natural variantⁱVAR_057573	121	S → C.Corresponds to variant rs2073152dbSNPEnsembl.	1
Natural variantⁱVAR_057574	132	V → G.Corresponds to variant rs11752608dbSNPEnsembl.	1
Natural variantⁱVAR_057575	159	V → I.Corresponds to variant rs2073151dbSNPEnsembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC004171 Genomic DNA. No translation available. AL035542 Genomic DNA. Translation: CAB44510.1. AL645927 Genomic DNA. Translation: CAI18051.1. AL662869 Genomic DNA. Translation: CAI17482.1. CR759808 Genomic DNA. Translation: CAQ07998.1. BX927232 Genomic DNA. Translation: CAQ08991.1. CH471081 Genomic DNA. Translation: EAX03191.1. BC069123 mRNA. Translation: AAH69123.1. BC101742 mRNA. Translation: AAI01743.1. BC101746 mRNA. Translation: AAI01747.1. BK004523 Genomic DNA. Translation: DAA04921.1.
RefSeqⁱ	NP_039224.2. NM_013936.3.
UniGeneⁱ	Hs.247862.

Genome annotation databases

Ensemblⁱ	ENST00000377140; ENSP00000366345; ENSG00000204690. ENST00000414415; ENSP00000414137; ENSG00000233481. ENST00000438569; ENSP00000415065; ENSG00000235966. ENST00000623183; ENSP00000485112; ENSG00000280236.
GeneIDⁱ	26529.
KEGGⁱ	hsa:26529.
UCSCⁱ	uc003nmf.4. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Cross-referencesⁱ

Web resourcesⁱ

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC004171 Genomic DNA. No translation available. AL035542 Genomic DNA. Translation: CAB44510.1. AL645927 Genomic DNA. Translation: CAI18051.1. AL662869 Genomic DNA. Translation: CAI17482.1. CR759808 Genomic DNA. Translation: CAQ07998.1. BX927232 Genomic DNA. Translation: CAQ08991.1. CH471081 Genomic DNA. Translation: EAX03191.1. BC069123 mRNA. Translation: AAH69123.1. BC101742 mRNA. Translation: AAI01743.1. BC101746 mRNA. Translation: AAI01747.1. BK004523 Genomic DNA. Translation: DAA04921.1.
RefSeqⁱ	NP_039224.2. NM_013936.3.
UniGeneⁱ	Hs.247862.

3D structure databases

ProteinModelPortalⁱ	P58182.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	P58182.
PhosphoSitePlusⁱ	P58182.

Polymorphism and mutation databases

BioMutaⁱ	OR12D2.
DMDMⁱ	288558820.

Proteomic databases

PaxDbⁱ	P58182.
PeptideAtlasⁱ	P58182.
PRIDEⁱ	P58182.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000377140; ENSP00000366345; ENSG00000204690. ENST00000414415; ENSP00000414137; ENSG00000233481. ENST00000438569; ENSP00000415065; ENSG00000235966. ENST00000623183; ENSP00000485112; ENSG00000280236.
GeneIDⁱ	26529.
KEGGⁱ	hsa:26529.
UCSCⁱ	uc003nmf.4. human.

Organism-specific databases

CTDⁱ	26529.
DisGeNETⁱ	26529.
GeneCardsⁱ	OR12D2.
H-InvDB	HIX0166173. HIX0166712. HIX0166973. HIX0167454. HIX0207641. HIX0207710. HIX0207764.
HGNCⁱ	HGNC:8178. OR12D2.
neXtProtⁱ	NX_P58182.
OpenTargetsⁱ	ENSG00000280236.
PharmGKBⁱ	PA32028.
GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IH3D. Eukaryota. ENOG410YBP5. LUCA.
GeneTreeⁱ	ENSGT00390000018942.
HOGENOMⁱ	HOG000041362.
HOVERGENⁱ	HBG017625.
InParanoidⁱ	P58182.
KOⁱ	K04257.
OMAⁱ	LACENTE.
OrthoDBⁱ	EOG091G0CKO.
PhylomeDBⁱ	P58182.
TreeFamⁱ	TF338273.

Enzyme and pathway databases

BioCycⁱ	ZFISH:ENSG00000168787-MONOMER.
Reactomeⁱ	R-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiⁱ	OR12D2.
GenomeRNAiⁱ	26529.
PROⁱ	P58182.

Gene expression databases

Bgeeⁱ	ENSG00000168787.
CleanExⁱ	HS_OR12D2.
ExpressionAtlasⁱ	P58182. baseline and differential.
Genevisibleⁱ	P58182. HS.

Family and domain databases

InterProⁱ	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTSⁱ	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITEⁱ	PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

O12D2_HUMAN

Accessionⁱ

Primary (citable) accession number: P58182
Secondary accession number(s): B0S862, Q5SUN9, Q6IET9

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	February 9, 2010
Last modified:	November 30, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P58182 (O12D2_HUMAN)

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Olfactory receptor 12D2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ