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What you can expect.

Your 23andMe reports include genetic analysis of the conditions and traits listed below.

These reports include genetic factors that are known to impact risk for certain conditions, can affect drug response and could be important for the health of your future family.

In addition, our reports on various traits cover both well-established genetic associations and more recent discoveries.

We update our reports over time as our scientific knowledge of how DNA affects health and traits evolve.

View reports by ethnicity →

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A gene is a segment of DNA that contains instructions for making proteins. Genes tell your body how to function and what traits to express. Humans have between 20,000 and 25,000 genes. Everyone has the genes listed, but certain variants and markers in these genes are associated with different conditions. Some variants and markers are located between genes (intergenic) as opposed to within a gene and are noted with an "n/a."
A variant is an altered version of a DNA sequence. Variants can be large or small, and can contribute to differences between individuals. Variants associated with disease are often called mutations.

Variant naming varies widely – variants may be named according to the change in DNA or protein sequence, though, many variants involved in drug response are named with an asterisk. A marker is a specific genomic location and is usually given a rs number. The rs number (or rsid) is used by researchers and databases to refer to specific markers.

23andMe reports on the listed variants and markers; these reports do not cover all possible genetic variants and markers associated with the listed conditions.

Genetic Risk Factors (11)

These reports tell you if you have genetic variants that are risk factors for various health conditions. Most of the time, having just one variant can be linked to higher risk for the condition.

Considerations:

  • Keep in mind that having one of these variants does not necessarily mean you will develop the condition.
  • These reports do not cover all possible genetic variants that could influence risk for these conditions.
  • Other non-genetic factors can also influence risk for these conditions.
  • Read more about 23andMe's scientific criteria for reporting genetic associations here.

Condition

Gene

Variant or Marker

SERPINA1
PI*S
PI*Z
F11
IVS14+1G>A
F283L
E117X
TTR
Thr60Ala,T60A, p.Thr80Ala, c.238A>G
Val30Met, V30M, p.Val50Met, c.148G>A
Val122Ile, V122I, p.Val142Ile, c.424G>A
F2
Prothrombin G20210A
F5
Factor V Leiden

Inherited Conditions (43)

The reports in this category tell you if you have genetic variants that have been linked to recessive conditions. Recessive conditions occur when a person has two variants for that condition, one inherited from each parent. A person with just one variant for these conditions is known as a carrier. Carriers do not have the condition, but they can pass a variant to their children.

Considerations:

  • These reports include only a subset of possible variants that may be linked to a condition. It is possible to have other variants not included in these reports.
  • If you have a family history of any of these conditions and are thinking about having children, you should discuss options for testing with your doctor.
  • Read more about 23andMe's scientific criteria for reporting genetic associations here.

Condition

Gene

Variant or Marker

SACS
6594delT
PKHD1
I3177T
I222V
T36M
I2957T
D3230fs (c.9689delA)
R496X
HBB
c.118C>T
c.47G>A
c.316-106C>G
c.-138C>T
c.92+1G>A
Hb C
c.316-197C>T
c.92+5G>C
c.*+113A>G
c.92+6T>C
c.52A>T
Hb E
c.92G>C
Hb S
c.93-21G>A
c.48G>A
c.-79A>G
BLM
BLM Ash
ASPA
E285A
A305E
Y231X
CFTR
DeltaF508
DeltaI507
A455E
R334W
R347P/H
G85E
V520F
1717-1G>A
1078delT
711+1G>T
621+1G>T
394delTT
N1303K
1898+1G>A
3659delC
2789+5G>A
3120+1G>A
3905insT
3849+10kbC>T
G551D
R553X
R560T
G542X
S549N
R1162X
W1282X
DPYD
*2A (IVS14+1G>A)
IKBKAP
IVS20+6T>C
R696P
ABCC8
F1387del
V187D
3989-9G>A
MEFV
M694I
V726A
M680I, C to G
P369S
E148Q
R761H
A744S
F479L
K695R
M694V
FANCC
R548X
IVS4+4A>T
322delG
G6PD
VAL68MET
ASN126ASP
BCS1L
S78G
GBA
V394L
N370S
84GG
SLC37A4
W118R
1042_1043delCT
ALDOB
A149P
N334K
A174D
delta4E4
SGCB
LGMD2E
SGCA
LGMD2D
FKRP
LGMD2I
ACADM
K304E
Y42H
S220L
R181C
L59F
MCOLN1
IVS3-2A>G
SMPD1
L302P
R496L
fsP330
SLC26A4
T416P
H723R
E384G
V138F
L445W
L236P
GRHPR
c.404+3_6delAAGT
103delG
SLC17A5
R39C
HBB
rs334
HEXA
R247W
IVS9+1G>A
R249W
G269S
IVS12+1G>C
1278insTATC
FAH
W262X
P261L
IVS6-1G>T
IVS12+5G>A
E357X

Drug Response (12)

These reports provide information about how you may respond to various drugs based on specific genetic variants. These reports may tell you how effective a drug may be, how sensitive you may be to a drug or how likely you are to have certain side effects based on your genetics.

Considerations:

  • Do not stop, start or change a drug regimen without consulting a doctor.
  • The information in these reports should not be used independently to determine or adjust any treatment plan. Many factors besides the variants covered in these reports can influence how a person responds to a drug.
  • Read more about 23andMe's scientific criteria for reporting genetic associations here.

Condition

Gene

Variant or Marker

19q13 region
rs8099917
CYP2C9
rs1799853
rs1057910
BCHE
Thr243Met (F1)
Gly390Val (F2)
Asp70Gly (A)
CYP2C9
rs1799853
rs1057910
TPMT
c.460G>A
c.238G>C
c.719A>G
CYP2C9
rs1799853
rs1057910
VKORC1
rs9923231

Traits (41)

These reports tell you about genetic variants that may influence different non-health related traits. Keep in mind that many traits are influenced by multiple factors. Traits may be influenced to varying degrees by genetics and the environment. This category includes noticeable traits like eye colour as well as subtle traits like timing of a person's first tooth.

Considerations:

  • These reports describe study findings observed in groups of people. The findings may not be representative of individuals.
  • Many of the genetic variants reported are associated with normal variation and may have small effects on the trait.
  • Many factors besides those described in the report may also influence the trait.

Condition

Gene

Variant or Marker

n/a
rs7903146
rs1799884
TAS2R38
rs713598
KITLG
rs12821256
HERC2
rs1667394
SLC24A4
rs12896399
n/a
rs7816345
rs4849884
rs17625845
n/a
rs2472297
rs4410790
n/a
rs762551
n/a
rs1172294
rs7759938
n/a
rs2741762
rs3930459
ABCC11
rs17822931
HERC2
rs12913832
n/a
rs1393350
rs12896399
n/a
rs2332175
rs314277
n/a
rs2153271
rs4778138
rs1805007
TCHH
rs17646946
n/a
rs3827760
n/a
rs6060371
rs1042725
n/a
rs1934177
n/a
rs1533995
rs3739070
rs12896399
LCT
rs4988235
AR
rs6625163
Chr 20 intergenic region
rs6113491
n/a
rs2003046
rs9287638
rs2073963
rs8085664
n/a
rs6548238
rs925946
rs7138803
rs9939609
rs13130484
rs4788102
rs10838738
rs10871777
rs12970134
n/a
rs17070145
n/a
rs1172294
rs10804533
rs9635758
rs6545572
rs7642134
rs4369815
n/a
rs16991615
ACTN3
rs1815739
n/a
rs10034228
rs560766
rs939661
FUT2
rs601338
n/a
rs1953558
n/a
rs6269
n/a
rs10427255
MC1R
D294H
R151C
R160W
n/a
rs1801282
rs5082
rs662799
n/a
rs9939609
rs1801282
rs1800588
rs4994
CHRNA3
rs1051730
n/a
rs838133
rs1421085
n/a
rs17179670
rs2281845
rs4491709
rs7924176

Keep in mind that many conditions and traits are influenced by multiple factors. Our reports cover only specific genetic factors, but there may be additional factors not included in these reports. Lifestyle and environment may also affect a person’s health and traits. Our reports are intended for information purposes only and do not diagnose disease or illness.

The genotyping services of 23andMe are performed in LabCorp's CLIA-certified (Clinical Laboratory Improvement Amendments), CAP-accredited (College of American Pathologists) laboratory in the United States. The information on this page is intended for research and educational purposes only and is not for diagnostic use.