pywsgi is a brand new and very simple Python module for web applications. Applications using pywsgi will work with WSGI, CGI, and mod_python; the differences between these environments are abstracted. It also handles sessions, cookies, and GET/POST data. It also comes with some useful tools for URL handling.

Some example code is here:

def handler(request):
    # The code of your actual web site is here.
    request.write('Hello World')
    request.start_session()
    for key, value in request.get_data():
        print "GET DATA:", key, value
    for key, value in request.post_data():
        print "POST DATA:", key, value
    for key, value in request.cookies():
        print "COOKIE:", key, value
    for key, value in request.session().data():
        print "SESSION DATA:", key, value

if __name__ == '__main__':
    from pywsgi import RequestHandler
    request_handler = RequestHandler(handler)

The above code will work with both, mod_wsgi and mod_cgi. Note that accessing GET, POST, COOKIE, and SESSION data is completely uniform via a dictionary-like Table object.
This initial release also comes with complete API documentation.

Links:
Download
Project page
API documentation
Handbook (PDF, incomplete)