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Protein

Androgen receptor

Gene

AR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.7 Publications
Isoform 3 and isoform 4 lack the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones.1 Publication

Miscellaneous

In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. The hormone-receptor complex appears to recognize discrete DNA sequences upstream of transcriptional start sites.
Transcriptional activity is enhanced by binding to RANBP9.
The level of tyrosine phosphorylation may serve as a diagnostic tool to predict patient outcome in response to hormone-ablation therapy. Inhibition of tyrosine phosphorylation may be an effective intervention target for hormone-refractory prostate cancer.

Enzyme regulationi

AIM-100 (4-amino-5,6-biaryl-furo[2,3-d]pyrimidine) suppresses TNK2-mediated phosphorylation at Tyr-269. Inhibits the binding of the Tyr-269 phosphorylated form to androgen-responsive enhancers (AREs) and its transcriptional activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei706Androgen1
Binding sitei753Androgen1
Binding sitei878Androgen1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi560 – 632Nuclear receptorPROSITE-ProRule annotationAdd BLAST73
Zinc fingeri560 – 580NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri596 – 620NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • androgen binding Source: UniProtKB
  • androgen receptor activity Source: UniProtKB
  • ATPase binding Source: MGI
  • beta-catenin binding Source: BHF-UCL
  • chromatin binding Source: UniProtKB
  • DNA binding Source: ProtInc
  • enzyme binding Source: UniProtKB
  • POU domain binding Source: Ensembl
  • protein dimerization activity Source: UniProtKB
  • receptor binding Source: UniProtKB
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding Source: BHF-UCL
  • RNA polymerase II transcription factor binding Source: BHF-UCL
  • steroid binding Source: UniProtKB-KW
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: NTNU_SB
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB
  • transcription factor binding Source: BHF-UCL
  • transcription regulatory region DNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • activation of prostate induction by androgen receptor signaling pathway Source: Ensembl
  • androgen receptor signaling pathway Source: UniProtKB
  • animal organ formation Source: Ensembl
  • cell-cell signaling Source: ProtInc
  • cell growth Source: UniProtKB
  • cell proliferation Source: UniProtKB
  • cellular response to steroid hormone stimulus Source: CAFA
  • cellular response to testosterone stimulus Source: Ensembl
  • epithelial cell differentiation involved in prostate gland development Source: Ensembl
  • epithelial cell morphogenesis Source: Ensembl
  • intracellular receptor signaling pathway Source: BHF-UCL
  • in utero embryonic development Source: Ensembl
  • lateral sprouting involved in mammary gland duct morphogenesis Source: Ensembl
  • Leydig cell differentiation Source: Ensembl
  • male genitalia morphogenesis Source: Ensembl
  • male somatic sex determination Source: Ensembl
  • mammary gland alveolus development Source: Ensembl
  • morphogenesis of an epithelial fold Source: Ensembl
  • multicellular organism growth Source: Ensembl
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of epithelial cell proliferation Source: Ensembl
  • negative regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
  • negative regulation of integrin biosynthetic process Source: BHF-UCL
  • negative regulation of transcription from RNA polymerase II promoter Source: CAFA
  • positive regulation of cell differentiation Source: UniProtKB
  • positive regulation of cell proliferation Source: BHF-UCL
  • positive regulation of epithelial cell proliferation involved in prostate gland development Source: Ensembl
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
  • positive regulation of integrin biosynthetic process Source: BHF-UCL
  • positive regulation of intracellular estrogen receptor signaling pathway Source: Ensembl
  • positive regulation of MAPK cascade Source: Ensembl
  • positive regulation of NF-kappaB transcription factor activity Source: BHF-UCL
  • positive regulation of phosphorylation Source: BHF-UCL
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase III promoter Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • prostate gland development Source: UniProtKB
  • prostate gland epithelium morphogenesis Source: Ensembl
  • prostate gland growth Source: Ensembl
  • protein deubiquitination Source: Reactome
  • protein oligomerization Source: MGI
  • regulation of catalytic activity Source: Ensembl
  • regulation of developmental growth Source: Ensembl
  • regulation of establishment of protein localization to plasma membrane Source: BHF-UCL
  • regulation of systemic arterial blood pressure Source: Ensembl
  • seminiferous tubule development Source: Ensembl
  • sex differentiation Source: UniProtKB
  • signal transduction Source: ProtInc
  • single fertilization Source: Ensembl
  • spermatogenesis Source: Ensembl
  • tertiary branching involved in mammary gland duct morphogenesis Source: Ensembl
  • transcription, DNA-templated Source: UniProtKB
  • transcription initiation from RNA polymerase II promoter Source: Reactome
  • transport Source: ProtInc

Keywordsi

Molecular functionActivator, DNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandLipid-binding, Metal-binding, Steroid-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-3371497. HSP90 chaperone cycle for steroid hormone receptors (SHR).
R-HSA-383280. Nuclear Receptor transcription pathway.
R-HSA-5625886. Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.
R-HSA-5689880. Ub-specific processing proteases.
SignaLinkiP10275.
SIGNORiP10275.

Chemistry databases

SwissLipidsiSLP:000001553.

Names & Taxonomyi

Protein namesi
Recommended name:
Androgen receptor
Alternative name(s):
Dihydrotestosterone receptor
Nuclear receptor subfamily 3 group C member 4
Gene namesi
Name:AR
Synonyms:DHTR, NR3C4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:644. AR.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: Reactome
  • nuclear chromatin Source: BHF-UCL
  • nuclear speck Source: CAFA
  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
  • plasma membrane Source: Ensembl
  • protein complex Source: MGI

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Androgen insensitivity syndrome (AIS)74 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn X-linked recessive form of pseudohermaphroditism due end-organ resistance to androgen. Affected males have female external genitalia, female breast development, blind vagina, absent uterus and female adnexa, and abdominal or inguinal testes, despite a normal 46,XY karyotype.
See also OMIM:300068
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0046792E → K in PAIS. 1 PublicationCorresponds to variant dbSNP:rs104894742Ensembl.1
Natural variantiVAR_009224196Q → R in AIS. 1 Publication1
Natural variantiVAR_009225257L → P in AIS. 1 Publication1
Natural variantiVAR_009226392P → R in AIS. 1 PublicationCorresponds to variant dbSNP:rs773996740Ensembl.1
Natural variantiVAR_009227392P → S in AIS. Corresponds to variant dbSNP:rs201934623Ensembl.1
Natural variantiVAR_009228445Q → R in AIS; unknown pathological significance. 1 Publication1
Natural variantiVAR_009719492G → S in AIS. 1
Natural variantiVAR_009721548L → F in PAIS. Corresponds to variant dbSNP:rs139524801Ensembl.1
Natural variantiVAR_009722549P → S in AIS. 1 PublicationCorresponds to variant dbSNP:rs137852588Ensembl.1
Natural variantiVAR_009723560C → Y in AIS. 1 Publication1
Natural variantiVAR_009726569G → W in PAIS. 1 Publication1
Natural variantiVAR_009727572Y → C in AIS. 1 Publication1
Natural variantiVAR_009728574A → D in AIS. 1
Natural variantiVAR_009731577C → F in AIS. 1 Publication1
Natural variantiVAR_009732577C → R in AIS. 1 Publication1
Natural variantiVAR_009733580C → F in AIS; reduced transcription and DNA binding. 1 PublicationCorresponds to variant dbSNP:rs137852586Ensembl.1
Natural variantiVAR_009734580C → Y in AIS. 1
Natural variantiVAR_009736582V → F in AIS. 2 Publications1
Natural variantiVAR_009737583F → S in PAIS. 1 Publication1
Natural variantiVAR_009738583F → Y in PAIS. 1 PublicationCorresponds to variant dbSNP:rs137852587Ensembl.1
Natural variantiVAR_009739583Missing in AIS. 1 Publication1
Natural variantiVAR_009740586R → K in AIS. 1
Natural variantiVAR_009743597A → T in AIS; abolishes dimerization. 2 PublicationsCorresponds to variant dbSNP:rs137852569Ensembl.1
Natural variantiVAR_009744598S → G in PAIS; associated with P-618 in a PAIS patient; normal androgen binding; does not activate transcription; impairs DNA binding. 1 PublicationCorresponds to variant dbSNP:rs142280455Ensembl.1
Natural variantiVAR_009746602C → F in AIS. 1 Publication1
Natural variantiVAR_009747605D → Y in PAIS. 1 Publication1
Natural variantiVAR_004684608R → Q in PAIS and breast cancer. 4 PublicationsCorresponds to variant dbSNP:rs137852573Ensembl.1
Natural variantiVAR_004685609R → K in PAIS and breast cancer; defective nuclear localization. 3 PublicationsCorresponds to variant dbSNP:rs137852576Ensembl.1
Natural variantiVAR_009748611N → T in PAIS. 1 Publication1
Natural variantiVAR_009749612C → Y in AIS. 1
Natural variantiVAR_009751616R → H in AIS and PAIS. 4 PublicationsCorresponds to variant dbSNP:rs754201976Ensembl.1
Natural variantiVAR_009752616R → P in AIS. 1
Natural variantiVAR_009750616Missing in AIS. 1 Publication1
Natural variantiVAR_009753617L → P in AIS. 1 Publication1
Natural variantiVAR_009754617L → R in PAIS. 1 Publication1
Natural variantiVAR_009755618R → P in AIS and PAIS; associated with G-598 in a PAIS patient; loss of DNA-binding activity. 2 Publications1
Natural variantiVAR_004687665I → N in AIS and PAIS. 1
Natural variantiVAR_009762672P → H in PAIS. 1
Natural variantiVAR_004688678L → P in AIS. 1 PublicationCorresponds to variant dbSNP:rs137852579Ensembl.1
Natural variantiVAR_009764682E → K in AIS. 2 Publications1
Natural variantiVAR_013474683P → T in PAIS. 1 Publication1
Natural variantiVAR_009766685V → I in AIS. 1
Natural variantiVAR_009767687C → R in PAIS. 1
Natural variantiVAR_009768688A → V in PAIS. 1
Natural variantiVAR_009769689G → E in AIS. 1
Natural variantiVAR_009770691Missing in PAIS. 1 Publication1
Natural variantiVAR_004689693Missing in AIS. 1
Natural variantiVAR_004690696D → H in AIS. 1 Publication1
Natural variantiVAR_004691696D → N in AIS; almost complete loss of androgen binding and transcription activation. 2 Publications1
Natural variantiVAR_004692696D → V in AIS. 1 Publication1
Natural variantiVAR_009771701L → M in AIS. 1
Natural variantiVAR_009772702L → F in AIS. 1
Natural variantiVAR_009773702L → H in AIS and prostate cancer. 3 PublicationsCorresponds to variant dbSNP:rs864622007Ensembl.1
Natural variantiVAR_009774703S → A in AIS. 1
Natural variantiVAR_009775704S → C in AIS. 1
Natural variantiVAR_004693704S → G in PAIS and AIS. 1 Publication1
Natural variantiVAR_009776706N → S in AIS. 2 Publications1
Natural variantiVAR_013475706N → Y in AIS. 1 Publication1
Natural variantiVAR_004694708L → R in AIS. 1 PublicationCorresponds to variant dbSNP:rs137852585Ensembl.1
Natural variantiVAR_009777709G → A in PAIS. 2 Publications1
Natural variantiVAR_009778709G → V in AIS. 1
Natural variantiVAR_009779711R → T in AIS. 1
Natural variantiVAR_013476712Q → E in PAIS. 1 Publication1
Natural variantiVAR_009780713L → F in PAIS. Corresponds to variant dbSNP:rs137852595Ensembl.1
Natural variantiVAR_009785723L → F in AIS. 1
Natural variantiVAR_009786724P → S in AIS. 1
Natural variantiVAR_009787725G → D in AIS and prostate cancer. 1
Natural variantiVAR_009790728N → K in AIS. 1 PublicationCorresponds to variant dbSNP:rs768869912Ensembl.1
Natural variantiVAR_009791729L → S in PAIS. 1
Natural variantiVAR_004696733D → N in AIS. 1 Publication1
Natural variantiVAR_004697733D → Y in AIS. 1
Natural variantiVAR_009792734Q → H in PAIS. 1
Natural variantiVAR_009793738I → T in PAIS. 1 Publication1
Natural variantiVAR_009794742W → R in AIS. 1 Publication1
Natural variantiVAR_004698743M → I in PAIS. 1 Publication1
Natural variantiVAR_009795743M → V in PAIS. 1 Publication1
Natural variantiVAR_013477744G → E in AIS. 1 PublicationCorresponds to variant dbSNP:rs137852600Ensembl.1
Natural variantiVAR_004699744G → V in PAIS and AIS. 4 PublicationsCorresponds to variant dbSNP:rs137852600Ensembl.1
Natural variantiVAR_009796745L → F in AIS and prostate cancer. 1
Natural variantiVAR_009797746M → T in PAIS. 1 Publication1
Natural variantiVAR_009798747V → M in PAIS. 1
Natural variantiVAR_009799749A → D in PAIS. 1
Natural variantiVAR_004700750M → V in PAIS and AIS. 3 Publications1
Natural variantiVAR_004701751G → D in AIS; loss of androgen binding. 1 Publication1
Natural variantiVAR_009804752W → R in AIS. 1
Natural variantiVAR_004702753R → Q in AIS. 2 Publications1
Natural variantiVAR_009805755F → L in PAIS and prostate cancer. 2 Publications1
Natural variantiVAR_004703755F → V in AIS. 2 Publications1
Natural variantiVAR_009807757N → S in PAIS. Corresponds to variant dbSNP:rs141425171Ensembl.1
Natural variantiVAR_009809759N → T in PAIS; 50% reduction in transactivation. 1 Publication1
Natural variantiVAR_009810760S → F in AIS. 1 Publication1
Natural variantiVAR_004704763L → F in AIS; loss of androgen binding. 1 Publication1
Natural variantiVAR_004705764Y → C in PAIS and prostate cancer; partial loss of androgen binding. 3 PublicationsCorresponds to variant dbSNP:rs137852567Ensembl.1
Natural variantiVAR_009812764Y → H in AIS. 1 Publication1
Natural variantiVAR_009813765F → L in AIS. 1 Publication1
Natural variantiVAR_004707766A → T in AIS; loss of androgen binding. 4 Publications1
Natural variantiVAR_009814766A → V in AIS. 1
Natural variantiVAR_009815767P → S in AIS. 1
Natural variantiVAR_009816768D → E in AIS. 1 Publication1
Natural variantiVAR_009817769L → P in AIS. 1
Natural variantiVAR_009818772N → H in PAIS. 1 Publication1
Natural variantiVAR_009819773E → A in PAIS. 1 Publication1
Natural variantiVAR_009820773E → G in PAIS. 1 Publication1
Natural variantiVAR_004709775R → C in AIS; frequent mutation; loss of androgen binding. 5 PublicationsCorresponds to variant dbSNP:rs137852562Ensembl.1
Natural variantiVAR_004708775R → H in AIS and PAIS; almost complete loss of androgen binding. 4 PublicationsCorresponds to variant dbSNP:rs137852572Ensembl.1
Natural variantiVAR_004710780R → W in AIS. 3 Publications1
Natural variantiVAR_004711781M → I in PAIS and AIS. 3 PublicationsCorresponds to variant dbSNP:rs137852589Ensembl.1
Natural variantiVAR_004712785C → Y in AIS; loss of androgen binding and of transactivation. 1 Publication1
Natural variantiVAR_004713788M → V in AIS. 1 PublicationCorresponds to variant dbSNP:rs137852570Ensembl.1
Natural variantiVAR_009822789R → S in AIS. 1
Natural variantiVAR_009823791L → F in AIS. 1 Publication1
Natural variantiVAR_004714795F → S in AIS. 1 Publication1
Natural variantiVAR_004715799Q → E in PAIS, AIS and prostate cancer; reduced transcription activation. 6 PublicationsCorresponds to variant dbSNP:rs137852591Ensembl.1
Natural variantiVAR_009826807C → Y in PAIS. 1
Natural variantiVAR_004716808M → R in AIS; loss of transactivation. 1 Publication1
Natural variantiVAR_009827808M → T in PAIS. 1 PublicationCorresponds to variant dbSNP:rs137852592Ensembl.1
Natural variantiVAR_004717808M → V in AIS; 25% androgen binding. 1 Publication1
Natural variantiVAR_009828813L → F in AIS. 1 Publication1
Natural variantiVAR_004718815S → N in AIS and PAIS. 1
Natural variantiVAR_009829821G → A in AIS. 1 Publication1
Natural variantiVAR_009830822L → V in PAIS. 1
Natural variantiVAR_013478828F → V in PAIS. 1 Publication1
Natural variantiVAR_004719832R → L in AIS. 1 Publication1
Natural variantiVAR_004720832R → Q in AIS; loss of androgen binding. 3 Publications1
Natural variantiVAR_009832835Y → C in AIS; loss of androgen binding. 1 Publication1
Natural variantiVAR_004721841R → C in AIS. 3 PublicationsCorresponds to variant dbSNP:rs137852577Ensembl.1
Natural variantiVAR_004722841R → G in PAIS. 1 Publication1
Natural variantiVAR_004723841R → H in AIS. 7 PublicationsCorresponds to variant dbSNP:rs9332969Ensembl.1
Natural variantiVAR_009229841R → S in PAIS. 1 Publication1
Natural variantiVAR_009833842I → S in PAIS. 1
Natural variantiVAR_004724843I → T in AIS. 2 PublicationsCorresponds to variant dbSNP:rs9332970Ensembl.1
Natural variantiVAR_009835855R → K in PAIS. 1
Natural variantiVAR_004725856R → C in AIS. 5 Publications1
Natural variantiVAR_004726856R → H in AIS; strongly reduced transcription activation. 5 PublicationsCorresponds to variant dbSNP:rs9332971Ensembl.1
Natural variantiVAR_009836857F → L in AIS. Corresponds to variant dbSNP:rs137852598Ensembl.1
Natural variantiVAR_009837864L → R in AIS. 1
Natural variantiVAR_009838865D → G in AIS. 1 Publication1
Natural variantiVAR_004727865D → N in AIS; loss of androgen binding. 1 Publication1
Natural variantiVAR_009839866S → P in AIS. Corresponds to variant dbSNP:rs137852597Ensembl.1
Natural variantiVAR_004728867V → E in AIS. 1
Natural variantiVAR_004729867V → L in PAIS. 3 PublicationsCorresponds to variant dbSNP:rs137852564Ensembl.1
Natural variantiVAR_004730867V → M in AIS and prostate cancer. 4 PublicationsCorresponds to variant dbSNP:rs137852564Ensembl.1
Natural variantiVAR_004731870I → M in PAIS. 2 PublicationsCorresponds to variant dbSNP:rs137852574Ensembl.1
Natural variantiVAR_009840871A → G in PAIS. 1 Publication1
Natural variantiVAR_009841871A → V in PAIS. 1 PublicationCorresponds to variant dbSNP:rs143040492Ensembl.1
Natural variantiVAR_009842872R → G in AIS. 1 Publication1
Natural variantiVAR_013479875H → R in AIS. 1 Publication1
Natural variantiVAR_013480880D → Y in AIS. 1 Publication1
Natural variantiVAR_009846882L → V in AIS. 1 Publication1
Natural variantiVAR_009847887M → V in AIS. Corresponds to variant dbSNP:rs755226547Ensembl.1
Natural variantiVAR_009848890V → M in AIS and PAIS. 2 Publications1
Natural variantiVAR_004733893P → L in AIS. 3 Publications1
Natural variantiVAR_004734896M → T in AIS; low androgen binding and transactivation. 2 Publications1
Natural variantiVAR_009852899I → T in AIS. 1
Natural variantiVAR_009854904V → M in PAIS. 1
Natural variantiVAR_009855905P → H in AIS. 1
Natural variantiVAR_009856905P → S in AIS. 1
Natural variantiVAR_004735908L → F in AIS; almost complete loss of transcription activation. 2 Publications1
Natural variantiVAR_009858910G → R in PAIS. 1 Publication1
Natural variantiVAR_009860912V → L in PAIS. 1 Publication1
Natural variantiVAR_004736914P → S in PAIS. 1
Natural variantiVAR_009861917F → L in AIS. 1 Publication1
Natural variantiVAR_009862918H → R in AIS. 1
Spinal and bulbar muscular atrophy X-linked 1 (SMAX1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry. Caused by trinucleotide CAG repeat expansion. In SMAX1 patients the number of Gln ranges from 38 to 62. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.
Disease descriptionAn X-linked recessive form of spinal muscular atrophy. Spinal muscular atrophy refers to a group of neuromuscular disorders characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMAX1 occurs only in men. Age at onset is usually in the third to fifth decade of life, but earlier involvement has been reported. It is characterized by slowly progressive limb and bulbar muscle weakness with fasciculations, muscle atrophy, and gynecomastia. The disorder is clinically similar to classic forms of autosomal spinal muscular atrophy.
See also OMIM:313200
Defects in AR may play a role in metastatic prostate cancer. The mutated receptor stimulates prostate growth and metastases development despite of androgen ablation. This treatment can reduce primary and metastatic lesions probably by inducing apoptosis of tumor cells when they express the wild-type receptor.
Androgen insensitivity, partial (PAIS)42 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder that is characterized by hypospadias, hypogonadism, gynecomastia, genital ambiguity, normal XY karyotype, and a pedigree pattern consistent with X-linked recessive inheritance. Some patients present azoospermia or severe oligospermia without other clinical manifestations.
See also OMIM:312300
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0046792E → K in PAIS. 1 PublicationCorresponds to variant dbSNP:rs104894742Ensembl.1
Natural variantiVAR_009721548L → F in PAIS. Corresponds to variant dbSNP:rs139524801Ensembl.1
Natural variantiVAR_009726569G → W in PAIS. 1 Publication1
Natural variantiVAR_009737583F → S in PAIS. 1 Publication1
Natural variantiVAR_009738583F → Y in PAIS. 1 PublicationCorresponds to variant dbSNP:rs137852587Ensembl.1
Natural variantiVAR_009744598S → G in PAIS; associated with P-618 in a PAIS patient; normal androgen binding; does not activate transcription; impairs DNA binding. 1 PublicationCorresponds to variant dbSNP:rs142280455Ensembl.1
Natural variantiVAR_009747605D → Y in PAIS. 1 Publication1
Natural variantiVAR_004684608R → Q in PAIS and breast cancer. 4 PublicationsCorresponds to variant dbSNP:rs137852573Ensembl.1
Natural variantiVAR_004685609R → K in PAIS and breast cancer; defective nuclear localization. 3 PublicationsCorresponds to variant dbSNP:rs137852576Ensembl.1
Natural variantiVAR_009748611N → T in PAIS. 1 Publication1
Natural variantiVAR_009751616R → H in AIS and PAIS. 4 PublicationsCorresponds to variant dbSNP:rs754201976Ensembl.1
Natural variantiVAR_009754617L → R in PAIS. 1 Publication1
Natural variantiVAR_009755618R → P in AIS and PAIS; associated with G-598 in a PAIS patient; loss of DNA-binding activity. 2 Publications1
Natural variantiVAR_004687665I → N in AIS and PAIS. 1
Natural variantiVAR_009762672P → H in PAIS. 1
Natural variantiVAR_013474683P → T in PAIS. 1 Publication1
Natural variantiVAR_009767687C → R in PAIS. 1
Natural variantiVAR_009768688A → V in PAIS. 1
Natural variantiVAR_009770691Missing in PAIS. 1 Publication1
Natural variantiVAR_004693704S → G in PAIS and AIS. 1 Publication1
Natural variantiVAR_009777709G → A in PAIS. 2 Publications1
Natural variantiVAR_013476712Q → E in PAIS. 1 Publication1
Natural variantiVAR_009780713L → F in PAIS. Corresponds to variant dbSNP:rs137852595Ensembl.1
Natural variantiVAR_009791729L → S in PAIS. 1
Natural variantiVAR_009792734Q → H in PAIS. 1
Natural variantiVAR_009793738I → T in PAIS. 1 Publication1
Natural variantiVAR_004698743M → I in PAIS. 1 Publication1
Natural variantiVAR_009795743M → V in PAIS. 1 Publication1
Natural variantiVAR_004699744G → V in PAIS and AIS. 4 PublicationsCorresponds to variant dbSNP:rs137852600Ensembl.1
Natural variantiVAR_009797746M → T in PAIS. 1 Publication1
Natural variantiVAR_009798747V → M in PAIS. 1
Natural variantiVAR_009799749A → D in PAIS. 1
Natural variantiVAR_004700750M → V in PAIS and AIS. 3 Publications1
Natural variantiVAR_009805755F → L in PAIS and prostate cancer. 2 Publications1
Natural variantiVAR_009807757N → S in PAIS. Corresponds to variant dbSNP:rs141425171Ensembl.1
Natural variantiVAR_009809759N → T in PAIS; 50% reduction in transactivation. 1 Publication1
Natural variantiVAR_004705764Y → C in PAIS and prostate cancer; partial loss of androgen binding. 3 PublicationsCorresponds to variant dbSNP:rs137852567Ensembl.1
Natural variantiVAR_009818772N → H in PAIS. 1 Publication1
Natural variantiVAR_009819773E → A in PAIS. 1 Publication1
Natural variantiVAR_009820773E → G in PAIS. 1 Publication1
Natural variantiVAR_004708775R → H in AIS and PAIS; almost complete loss of androgen binding. 4 PublicationsCorresponds to variant dbSNP:rs137852572Ensembl.1
Natural variantiVAR_004711781M → I in PAIS and AIS. 3 PublicationsCorresponds to variant dbSNP:rs137852589Ensembl.1
Natural variantiVAR_004715799Q → E in PAIS, AIS and prostate cancer; reduced transcription activation. 6 PublicationsCorresponds to variant dbSNP:rs137852591Ensembl.1
Natural variantiVAR_009826807C → Y in PAIS. 1
Natural variantiVAR_009827808M → T in PAIS. 1 PublicationCorresponds to variant dbSNP:rs137852592Ensembl.1
Natural variantiVAR_004718815S → N in AIS and PAIS. 1
Natural variantiVAR_009830822L → V in PAIS. 1
Natural variantiVAR_013478828F → V in PAIS. 1 Publication1
Natural variantiVAR_004722841R → G in PAIS. 1 Publication1
Natural variantiVAR_009229841R → S in PAIS. 1 Publication1
Natural variantiVAR_009833842I → S in PAIS. 1
Natural variantiVAR_009835855R → K in PAIS. 1
Natural variantiVAR_004729867V → L in PAIS. 3 PublicationsCorresponds to variant dbSNP:rs137852564Ensembl.1
Natural variantiVAR_004731870I → M in PAIS. 2 PublicationsCorresponds to variant dbSNP:rs137852574Ensembl.1
Natural variantiVAR_009840871A → G in PAIS. 1 Publication1
Natural variantiVAR_009841871A → V in PAIS. 1 PublicationCorresponds to variant dbSNP:rs143040492Ensembl.1
Natural variantiVAR_009848890V → M in AIS and PAIS. 2 Publications1
Natural variantiVAR_009854904V → M in PAIS. 1
Natural variantiVAR_009858910G → R in PAIS. 1 Publication1
Natural variantiVAR_009860912V → L in PAIS. 1 Publication1
Natural variantiVAR_004736914P → S in PAIS. 1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi83S → A: Reduced cell growth. 1 Publication1
Mutagenesisi225Y → F: Decrease of CSK-induced phosphorylation. 1 Publication1
Mutagenesisi269Y → F: Decrease of CSK-induced phosphorylation and phosphorylation by TNK2. Complete loss of TNK2-dependent phosphorylation; when associated with F-365. 2 Publications1
Mutagenesisi309Y → F: Decrease of CSK-induced phosphorylation. 1 Publication1
Mutagenesisi348Y → F: Decrease of CSK-induced phosphorylation. 1 Publication1
Mutagenesisi359Y → F: Decrease of CSK-induced phosphorylation. 1 Publication1
Mutagenesisi364Y → F: Decrease of CSK-induced phosphorylation. 1 Publication1
Mutagenesisi365Y → F: Decrease of CSK-induced phosphorylation and phosphorylation by TNK2. Complete loss of TNK2-dependent phosphorylation; when associated with F-269. 2 Publications1
Mutagenesisi395Y → F: Decrease of CSK-induced phosphorylation. 1 Publication1
Mutagenesisi535Y → F: Greatest decrease of CSK-induced phosphorylation and inhibition of transcriptional activity induced by EGF. 1 Publication1
Mutagenesisi552Y → F: Decrease in CSK-induced phosphorylation. 1 Publication1
Mutagenesisi702L → A: Alters receptor specificity, so that transcription is activated by the antiandrogen cyproterone acetate. 1 Publication1
Mutagenesisi721K → A: Loss of transcription activation in the presence of androgen and of interaction with NCOA2. 2 Publications1
Mutagenesisi742W → L: Strongly decreased transcription activation in the presence of androgen. 1 Publication1
Mutagenesisi846K → R: Prevents ubiquitination by RNF6. Prevents AR transcriptional activation by RNF14 in absence of hormone. 1 Publication1
Mutagenesisi848K → R: Partially prevents ubiquitination by RNF6. 1 Publication1
Mutagenesisi898E → A or Q: Reduced transcription activation in the presence of androgen. 2 Publications1
Mutagenesisi898E → K or R: Loss of transcription activation in the presence of androgen. 2 Publications1
Mutagenesisi916Y → F: Decrease in CSK-induced phosphorylation. 1 Publication1

Keywords - Diseasei

Disease mutation, Neurodegeneration, Pseudohermaphroditism

Organism-specific databases

DisGeNETi367.
MalaCardsiAR.
MIMi300068. phenotype.
312300. phenotype.
313200. phenotype.
OpenTargetsiENSG00000169083.
Orphaneti99429. Complete androgen insensitivity syndrome.
440. Familial hypospadias.
481. Kennedy disease.
90797. Partial androgen insensitivity syndrome.
PharmGKBiPA57.

Chemistry databases

ChEMBLiCHEMBL1871.
DrugBankiDB02932. (2r)-N-[4-Cyano-3-(Trifluoromethyl)Phenyl]-3-[(4-Fluorophenyl)Sulfonyl]-2-Hydroxy-2-Methylpropanamide.
DB07422. (2S)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-(pentafluorophenoxy)propanamide.
DB07419. (2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide.
DB07423. (2S)-3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide.
DB07039. (2S)-N-(4-cyano-3-iodophenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide.
DB07454. (R)-3-BROMO-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE.
DB01128. Bicalutamide.
DB01541. Boldenone.
DB01564. Calusterone.
DB04839. Cyproterone acetate.
DB01406. Danazol.
DB01481. Delta1-dihydrotestosterone.
DB02901. Dihydrotestosterone.
DB01395. Drospirenone.
DB00858. Drostanolone.
DB08899. Enzalutamide.
DB13155. Esculin.
DB00687. Fludrocortisone.
DB02266. Flufenamic Acid.
DB01185. Fluoxymesterone.
DB00499. Flutamide.
DB01026. Ketoconazole.
DB00367. Levonorgestrel.
DB05234. LGD2941.
DB05094. MDV3100.
DB06710. Methyltestosterone.
DB02998. Methyltrienolone.
DB08804. Nandrolone decanoate.
DB00984. Nandrolone phenpropionate.
DB00665. Nilutamide.
DB09389. Norgestrel.
DB00621. Oxandrolone.
DB06412. Oxymetholone.
DB01708. Prasterone.
DB07769. S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE.
DB00421. Spironolactone.
DB00624. Testosterone.
DB01420. Testosterone Propionate.
DB08867. Ulipristal.
GuidetoPHARMACOLOGYi628.

Polymorphism and mutation databases

BioMutaiAR.
DMDMi113830.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000537041 – 920Androgen receptorAdd BLAST920

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83Phosphoserine; by CDK91 Publication1
Modified residuei96PhosphoserineCombined sources1
Modified residuei225Phosphotyrosine; by CSK1 Publication1
Modified residuei258PhosphoserineCombined sources1
Modified residuei269Phosphotyrosine; by CSK and TNK23 Publications1
Modified residuei309Phosphotyrosine; by CSK1 Publication1
Modified residuei348Phosphotyrosine; by CSK1 Publication1
Modified residuei359Phosphotyrosine; by CSK1 Publication1
Modified residuei364Phosphotyrosine; by CSK1 Publication1
Modified residuei365Phosphotyrosine; by CSK and TNK22 Publications1
Cross-linki388Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Modified residuei395Phosphotyrosine; by CSK1 Publication1
Cross-linki521Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Modified residuei535Phosphotyrosine; by CSK1 Publication1
Modified residuei552Phosphotyrosine; by CSK1 Publication1
Modified residuei651Phosphoserine; by STK4/MST11 Publication1
Cross-linki846Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki848Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei916Phosphotyrosine; by CSK1 Publication1

Post-translational modificationi

Sumoylated on Lys-388 (major) and Lys-521. Ubiquitinated. Deubiquitinated by USP26. 'Lys-6' and 'Lys-27'-linked polyubiquitination by RNF6 modulates AR transcriptional activity and specificity.3 Publications
Phosphorylated in prostate cancer cells in response to several growth factors including EGF. Phosphorylation is induced by c-Src kinase (CSK). Tyr-535 is one of the major phosphorylation sites and an increase in phosphorylation and Src kinase activity is associated with prostate cancer progression. Phosphorylation by TNK2 enhances the DNA-binding and transcriptional activity and may be responsible for androgen-independent progression of prostate cancer. Phosphorylation at Ser-83 by CDK9 regulates AR promoter selectivity and cell growth. Phosphorylation by PAK6 leads to AR-mediated transcription inhibition.6 Publications
Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation.1 Publication

Keywords - PTMi

Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP10275.
MaxQBiP10275.
PaxDbiP10275.
PeptideAtlasiP10275.
PRIDEiP10275.
TopDownProteomicsiP10275-1. [P10275-1]

PTM databases

iPTMnetiP10275.
PhosphoSitePlusiP10275.
SwissPalmiP10275.

Miscellaneous databases

PMAP-CutDBiB1AKD7.

Expressioni

Tissue specificityi

Isoform 2 is mainly expressed in heart and skeletal muscle (PubMed:15634333). Isoform 3 is expressed by basal and stromal cells of prostate (at protein level) (PubMed:19244107).2 Publications

Gene expression databases

BgeeiENSG00000169083.
CleanExiHS_AR.
ExpressionAtlasiP10275. baseline and differential.
GenevisibleiP10275. HS.

Organism-specific databases

HPAiCAB000001.
CAB065764.
HPA065701.

Interactioni

Subunit structurei

Binds DNA as a homodimer. Part of a ternary complex containing AR, EFCAB6/DJBP and PARK7. Interacts with HIPK3 and NR0B2 in the presence of androgen. The ligand binding domain interacts with KAT7/HBO1 in the presence of dihydrotestosterone. Interacts with EFCAB6/DJBP, PELP1, PQBP1, RANBP9, RBAK, SPDEF, SRA1, TGFB1I1, ZNF318 and RREB1. Interacts with ZMIZ1/ZIMP10 and ZMIZ2/ZMIP7 which both enhance its transactivation activity. Interacts with SLC30A9 and RAD54L2/ARIP4. Interacts via the ligand-binding domain with LXXLL and FXXLF motifs from NCOA1, NCOA2, NCOA3, NCOA4 and MAGEA11. The AR N-terminal poly-Gln region binds Ran resulting in enhancement of AR-mediated transactivation. Ran-binding decreases as the poly-Gln length increases. Interacts with HIP1 (via coiled coil domain). Interacts (via ligand-binding domain) with TRIM68. Interacts with TNK2. Interacts with USP26. Interacts with RNF6. Interacts (regulated by RNF6 probably through polyubiquitination) with RNF14; regulates AR transcriptional activity. Interacts with PRMT2 and TRIM24. Interacts with RACK1. Interacts with RANBP10; this interaction enhances dihydrotestosterone-induced AR transcriptional activity. Interacts with PRPF6 in a hormone-independent way; this interaction enhances dihydrotestosterone-induced AR transcriptional activity. Interacts with STK4/MST1. Interacts with ZIPK/DAPK3. Interacts with LPXN. Interacts with MAK. Part of a complex containing AR, MAK and NCOA3. Interacts with CRY1. Interacts with CCAR1 and GATA2.37 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei721Interaction with coactivator LXXL motif1
Sitei898Interaction with coactivator FXXLF motif1

Binary interactionsi

WithEntry#Exp.IntActNotes
ABL1P005192EBI-608057,EBI-375543
BLKP514513EBI-608057,EBI-2105445
BLNKQ8WV282EBI-608057,EBI-2623522
BTG2P785434EBI-608057,EBI-1047576
CASP8Q147903EBI-608057,EBI-78060
CREBBPQ927932EBI-608057,EBI-81215
CTDSP2O145953EBI-608057,EBI-2802973
CTNNB1P352228EBI-608057,EBI-491549
DAXXQ9UER75EBI-608057,EBI-77321
DDCP207112EBI-608057,EBI-1632155
ERGP113083EBI-608057,EBI-79704
FESP073323EBI-608057,EBI-1055635
FGRP097693EBI-608057,EBI-1383732
FOXH1O755933EBI-608057,EBI-1759806
Foxo1Q9R1E04EBI-608057,EBI-1371343From Mus musculus.
GRB7Q144513EBI-608057,EBI-970191
HDAC4P565244EBI-608057,EBI-308629
HIF1AQ166652EBI-608057,EBI-447269
IFI16Q166663EBI-608057,EBI-2867186
INPPL1O153573EBI-608057,EBI-1384248
JMJD1CQ156522EBI-608057,EBI-1224969
JUNDP175352EBI-608057,EBI-2682803
KAT7O952515EBI-608057,EBI-473199
KLK3P072883EBI-608057,EBI-1220791
LCKP062397EBI-608057,EBI-1348
LYNP079485EBI-608057,EBI-79452
MAKP207945EBI-608057,EBI-3911321
MATKP426794EBI-608057,EBI-751664
MDM2Q009872EBI-608057,EBI-389668
NCOA2Q155962EBI-608057,EBI-81236
NCOA6Q146862EBI-608057,EBI-78670
NSD2O960285EBI-608057,EBI-2693298
PARK7Q994976EBI-608057,EBI-1164361
PIK3R1P279865EBI-608057,EBI-79464
PIK3R2O0045914EBI-608057,EBI-346930
PIK3R3Q9256937EBI-608057,EBI-79893
PLCG1P1917422EBI-608057,EBI-79387
PLCG2P168856EBI-608057,EBI-617403
PRDX1Q068303EBI-608057,EBI-353193
PTPN11Q0612412EBI-608057,EBI-297779
RASA1P2093616EBI-608057,EBI-1026476
RNF14Q9UBS82EBI-608057,EBI-2130308
RNF6Q9Y25210EBI-608057,EBI-2341483
SH2D1BO147963EBI-608057,EBI-3923013
SH2D2AQ9NP316EBI-608057,EBI-490630
SHC1P2935314EBI-608057,EBI-78835
SHC4Q6S5L83EBI-608057,EBI-9453524
SHEQ5VZ183EBI-608057,EBI-3956977
Siah2Q069866EBI-608057,EBI-957413From Mus musculus.
SMAD1Q157976EBI-608057,EBI-1567153
SOCS6O145444EBI-608057,EBI-3929549
SRCP129317EBI-608057,EBI-621482
STAP1Q9ULZ22EBI-608057,EBI-6083058
SUMO1P631657EBI-608057,EBI-80140
TNS1Q9HBL03EBI-608057,EBI-3389814
YES1P079475EBI-608057,EBI-515331

GO - Molecular functioni

  • ATPase binding Source: MGI
  • beta-catenin binding Source: BHF-UCL
  • enzyme binding Source: UniProtKB
  • POU domain binding Source: Ensembl
  • protein dimerization activity Source: UniProtKB
  • receptor binding Source: UniProtKB
  • RNA polymerase II transcription factor binding Source: BHF-UCL
  • transcription factor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi106862. 241 interactors.
DIPiDIP-125N.
IntActiP10275. 108 interactors.
MINTiMINT-94801.
STRINGi9606.ENSP00000363822.

Chemistry databases

BindingDBiP10275.

Structurei

Secondary structure

1920
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi22 – 29Combined sources8
Beta strandi667 – 669Combined sources3
Helixi673 – 681Combined sources9
Beta strandi692 – 694Combined sources3
Helixi698 – 721Combined sources24
Helixi726 – 728Combined sources3
Helixi731 – 758Combined sources28
Beta strandi761 – 766Combined sources6
Beta strandi769 – 771Combined sources3
Helixi773 – 778Combined sources6
Helixi782 – 797Combined sources16
Helixi802 – 812Combined sources11
Beta strandi815 – 818Combined sources4
Helixi825 – 843Combined sources19
Turni844 – 846Combined sources3
Turni850 – 852Combined sources3
Helixi853 – 883Combined sources31
Helixi885 – 888Combined sources4
Helixi894 – 902Combined sources9
Helixi904 – 908Combined sources5
Beta strandi911 – 914Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E3GX-ray2.40A658-920[»]
1GS4X-ray1.95A671-918[»]
1T5ZX-ray2.30A670-920[»]
1T63X-ray2.07A670-919[»]
1T65X-ray1.66A670-920[»]
1XJ7X-ray2.70A664-920[»]
1XOWX-ray1.80A672-920[»]
B20-30[»]
1XQ3X-ray2.25A672-920[»]
1Z95X-ray1.80A673-918[»]
2AM9X-ray1.64A655-920[»]
2AMAX-ray1.90A655-920[»]
2AMBX-ray1.75A655-920[»]
2AO6X-ray1.89A672-920[»]
2AX6X-ray1.50A665-920[»]
2AX7X-ray1.90A665-920[»]
2AX8X-ray1.70A665-920[»]
2AX9X-ray1.65A665-920[»]
2AXAX-ray1.80A665-920[»]
2HVCX-ray2.10A670-919[»]
2OZ7X-ray1.80A672-920[»]
2PIOX-ray2.03A670-920[»]
2PIPX-ray1.80L670-920[»]
2PIQX-ray2.40A670-920[»]
2PIRX-ray2.10A670-920[»]
2PITX-ray1.76A670-920[»]
2PIUX-ray2.12A670-920[»]
2PIVX-ray1.95A670-920[»]
2PIWX-ray2.58A670-920[»]
2PIXX-ray2.40A670-920[»]
2PKLX-ray2.49A670-920[»]
2PNUX-ray1.65A655-920[»]
2Q7IX-ray1.87A664-920[»]
B20-30[»]
2Q7JX-ray1.90A664-920[»]
2Q7KX-ray1.80A664-920[»]
B20-30[»]
2Q7LX-ray1.92A664-920[»]
2YHDX-ray2.20A672-920[»]
2YLOX-ray2.50A665-920[»]
2YLPX-ray2.30A665-920[»]
2YLQX-ray2.40A665-920[»]
2Z4JX-ray2.60A672-919[»]
3B5RX-ray1.80A672-920[»]
3B65X-ray1.80A672-920[»]
3B66X-ray1.65A672-920[»]
3B67X-ray1.90A672-920[»]
3B68X-ray1.90A672-920[»]
3BTRX-ray2.60B622-636[»]
3L3XX-ray1.55A671-919[»]
3L3ZX-ray2.00A671-919[»]
3RLJX-ray1.90A672-918[»]
3RLLX-ray1.70A672-918[»]
3V49X-ray1.70A655-920[»]
B21-31[»]
3V4AX-ray1.95A672-920[»]
B21-31[»]
3ZQTX-ray2.29A665-920[»]
4HLWX-ray2.50A665-920[»]
4K7AX-ray2.44A671-919[»]
4OEAX-ray2.12A671-920[»]
4OEDX-ray2.79A671-920[»]
4OEYX-ray1.83A671-920[»]
4OEZX-ray1.80A671-920[»]
4OFRX-ray2.26A671-920[»]
4OFUX-ray2.12A671-920[»]
4OGHX-ray2.98A671-920[»]
4OH5X-ray2.00A671-920[»]
4OH6X-ray3.56A671-920[»]
4OHAX-ray1.42A671-920[»]
4OILX-ray2.51A671-920[»]
4OIUX-ray3.01A671-920[»]
4OJ9X-ray3.31A671-920[»]
4OJBX-ray2.00A671-920[»]
4OK1X-ray2.09A671-920[»]
4OKBX-ray2.95A671-920[»]
4OKTX-ray2.50A671-920[»]
4OKWX-ray2.00A671-920[»]
4OKXX-ray2.10A671-920[»]
4OLMX-ray2.80A671-920[»]
4QL8X-ray2.10A663-920[»]
5CJ6X-ray2.07A642-920[»]
B21-30[»]
5JJMX-ray2.15A/B/C/D669-920[»]
5T8EX-ray2.71A672-920[»]
5T8JX-ray2.70A672-920[»]
DisProtiDP00492.
ProteinModelPortaliP10275.
SMRiP10275.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10275.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 559ModulatingAdd BLAST559
Regioni552 – 919Interaction with LPXN1 PublicationAdd BLAST368
Regioni572 – 662Interaction with HIPK3By similarityAdd BLAST91
Regioni592 – 919Interaction with CCAR11 PublicationAdd BLAST328
Regioni625 – 919Interaction with KAT71 PublicationAdd BLAST295
Regioni691 – 919Ligand-bindingAdd BLAST229

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi58 – 120Gln-richAdd BLAST63
Compositional biasi58 – 80Poly-GlnAdd BLAST23
Compositional biasi86 – 91Poly-Gln6
Compositional biasi195 – 199Poly-Gln5
Compositional biasi374 – 383Poly-Pro10
Compositional biasi398 – 404Poly-Ala7
Compositional biasi451 – 473Poly-GlyAdd BLAST23

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. In the presence of bound steroid the ligand-binding domain interacts with the N-terminal modulating domain, and thereby activates AR transcription factor activity. Agonist binding is required for dimerization and binding to target DNA. The transcription factor activity of the complex formed by ligand-activated AR and DNA is modulated by interactions with coactivator and corepressor proteins. Interaction with RANBP9 is mediated by both the N-terminal domain and the DNA-binding domain. Interaction with EFCAB6/DJBP is mediated by the DNA-binding domain.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri560 – 580NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri596 – 620NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00760000118887.
HOVERGENiHBG007583.
InParanoidiP10275.
KOiK08557.
OMAiYGDMRLE.
OrthoDBiEOG091G032J.
PhylomeDBiP10275.
TreeFamiTF350286.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR001103. Andrgn_rcpt.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001628. Znf_hrmn_rcpt.
PfamiView protein in Pfam
PF02166. Androgen_recep. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
PRINTSiPR00521. ANDROGENR.
PR00047. STROIDFINGER.
SMARTiView protein in SMART
SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiView protein in PROSITE
PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P10275-1) [UniParc]FASTAAdd to basket
Also known as: AR-B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVQLGLGRV YPRPPSKTYR GAFQNLFQSV REVIQNPGPR HPEAASAAPP
60 70 80 90 100
GASLLLLQQQ QQQQQQQQQQ QQQQQQQQQQ ETSPRQQQQQ QGEDGSPQAH
110 120 130 140 150
RRGPTGYLVL DEEQQPSQPQ SALECHPERG CVPEPGAAVA ASKGLPQQLP
160 170 180 190 200
APPDEDDSAA PSTLSLLGPT FPGLSSCSAD LKDILSEAST MQLLQQQQQE
210 220 230 240 250
AVSEGSSSGR AREASGAPTS SKDNYLGGTS TISDNAKELC KAVSVSMGLG
260 270 280 290 300
VEALEHLSPG EQLRGDCMYA PLLGVPPAVR PTPCAPLAEC KGSLLDDSAG
310 320 330 340 350
KSTEDTAEYS PFKGGYTKGL EGESLGCSGS AAAGSSGTLE LPSTLSLYKS
360 370 380 390 400
GALDEAAAYQ SRDYYNFPLA LAGPPPPPPP PHPHARIKLE NPLDYGSAWA
410 420 430 440 450
AAAAQCRYGD LASLHGAGAA GPGSGSPSAA ASSSWHTLFT AEEGQLYGPC
460 470 480 490 500
GGGGGGGGGG GGGGGGGGGG GGGEAGAVAP YGYTRPPQGL AGQESDFTAP
510 520 530 540 550
DVWYPGGMVS RVPYPSPTCV KSEMGPWMDS YSGPYGDMRL ETARDHVLPI
560 570 580 590 600
DYYFPPQKTC LICGDEASGC HYGALTCGSC KVFFKRAAEG KQKYLCASRN
610 620 630 640 650
DCTIDKFRRK NCPSCRLRKC YEAGMTLGAR KLKKLGNLKL QEEGEASSTT
660 670 680 690 700
SPTEETTQKL TVSHIEGYEC QPIFLNVLEA IEPGVVCAGH DNNQPDSFAA
710 720 730 740 750
LLSSLNELGE RQLVHVVKWA KALPGFRNLH VDDQMAVIQY SWMGLMVFAM
760 770 780 790 800
GWRSFTNVNS RMLYFAPDLV FNEYRMHKSR MYSQCVRMRH LSQEFGWLQI
810 820 830 840 850
TPQEFLCMKA LLLFSIIPVD GLKNQKFFDE LRMNYIKELD RIIACKRKNP
860 870 880 890 900
TSCSRRFYQL TKLLDSVQPI ARELHQFTFD LLIKSHMVSV DFPEMMAEII
910 920
SVQVPKILSG KVKPIYFHTQ
Length:920
Mass (Da):99,188
Last modified:March 16, 2016 - v3
Checksum:iA73432C55D39AE06
GO
Isoform 2 (identifier: P10275-2) [UniParc]FASTAAdd to basket
Also known as: AR-A, Variant AR45

The sequence of this isoform differs from the canonical sequence as follows:
     1-532: Missing.
     533-539: GPYGDMR → MILWLHS

Show »
Length:388
Mass (Da):44,643
Checksum:i495BAE974B4EFC75
GO
Isoform 3 (identifier: P10275-3) [UniParc]FASTAAdd to basket
Also known as: AR3

The sequence of this isoform differs from the canonical sequence as follows:
     629-644: ARKLKKLGNLKLQEEG → EKFRVGNCKHLKMTRP
     645-920: Missing.

Note: Minor isoform up-regulated in prostate cancer cells.1 Publication
Show »
Length:644
Mass (Da):67,376
Checksum:i7A6B1F965E05774E
GO
Isoform 4 (identifier: P10275-4) [UniParc]FASTAAdd to basket
Also known as: AR4

The sequence of this isoform differs from the canonical sequence as follows:
     630-648: RKLKKLGNLKLQEEGEASS → AVVVSERILRVFGVSEWLP
     649-920: Missing.

Note: Minor isoform identified in prostate cancer cells.1 Publication
Show »
Length:648
Mass (Da):67,659
Checksum:i62009F73BA61300D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti168G → A in AAA51780 (PubMed:2342476).Curated1
Sequence conflicti214A → R (PubMed:2911578).Curated1
Sequence conflicti214A → R in AAA51771 (PubMed:2293020).Curated1
Sequence conflicti214A → R in AAA51772 (PubMed:2293020).Curated1
Sequence conflicti476G → E in AAA51775 (PubMed:3174628).Curated1
Sequence conflicti476G → E in AAA51770 (PubMed:3353726).Curated1
Sequence conflicti566E → K in AAA51774 (PubMed:3377788).Curated1
Sequence conflicti635L → P in AAB21256 (PubMed:1775137).Curated1
Sequence conflicti635L → P in AAB21257 (PubMed:1775137).Curated1
Sequence conflicti676N → I in AAB21256 (PubMed:1775137).Curated1
Sequence conflicti676N → I in AAB21257 (PubMed:1775137).Curated1
Sequence conflicti811L → M in AAA51780 (PubMed:2342476).Curated1

Polymorphismi

The poly-Gln region of AR is highly polymorphic and the number of Gln varies in the population (from 17 to 26). A smaller size of the poly-Gln region may be associated with the development of prostate cancer.4 Publications
The poly-Gly region of AR is polymorphic and ranges from 24 to 31 Gly. A poly-Gly region shorter or equal to 23 may be associated with the development of androgenetic alopecia.2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0046792E → K in PAIS. 1 PublicationCorresponds to variant dbSNP:rs104894742Ensembl.1
Natural variantiVAR_00468054L → S in prostate cancer. 1
Natural variantiVAR_00468157L → Q in prostate cancer. 1 PublicationCorresponds to variant dbSNP:rs78686797Ensembl.1
Natural variantiVAR_00971164Q → R in prostate cancer. 1
Natural variantiVAR_009712114Q → H in prostate cancer. 1
Natural variantiVAR_009713182K → R in prostate cancer. 1
Natural variantiVAR_009224196Q → R in AIS. 1 Publication1
Natural variantiVAR_009714207S → R1 PublicationCorresponds to variant dbSNP:rs374549047Ensembl.1
Natural variantiVAR_009715216G → R Functional polymorphism; 20% lower transactivation capacity. 2 PublicationsCorresponds to variant dbSNP:rs199554641Ensembl.1
Natural variantiVAR_009225257L → P in AIS. 1 Publication1
Natural variantiVAR_009716268M → T in prostate cancer. 1
Natural variantiVAR_009717271P → S in prostate cancer. 1
Natural variantiVAR_009718342P → L in prostate cancer. 1 PublicationCorresponds to variant dbSNP:rs138454018Ensembl.1
Natural variantiVAR_009226392P → R in AIS. 1 PublicationCorresponds to variant dbSNP:rs773996740Ensembl.1
Natural variantiVAR_009227392P → S in AIS. Corresponds to variant dbSNP:rs201934623Ensembl.1
Natural variantiVAR_009228445Q → R in AIS; unknown pathological significance. 1 Publication1
Natural variantiVAR_009719492G → S in AIS. 1
Natural variantiVAR_009720529D → G in prostate cancer. 1
Natural variantiVAR_009721548L → F in PAIS. Corresponds to variant dbSNP:rs139524801Ensembl.1
Natural variantiVAR_009722549P → S in AIS. 1 PublicationCorresponds to variant dbSNP:rs137852588Ensembl.1
Natural variantiVAR_009723560C → Y in AIS. 1 Publication1
Natural variantiVAR_009725569G → V in a patient with isolated hypospadias. 1 Publication1
Natural variantiVAR_009726569G → W in PAIS. 1 Publication1
Natural variantiVAR_009727572Y → C in AIS. 1 Publication1
Natural variantiVAR_009728574A → D in AIS. 1
Natural variantiVAR_009729575L → P in prostate cancer. 1
Natural variantiVAR_009730576T → A in prostate cancer. 1 Publication1
Natural variantiVAR_009731577C → F in AIS. 1 Publication1
Natural variantiVAR_009732577C → R in AIS. 1 Publication1
Natural variantiVAR_009733580C → F in AIS; reduced transcription and DNA binding. 1 PublicationCorresponds to variant dbSNP:rs137852586Ensembl.1
Natural variantiVAR_009734580C → Y in AIS. 1
Natural variantiVAR_009735581K → R in prostate cancer. 1 Publication1
Natural variantiVAR_009736582V → F in AIS. 2 Publications1
Natural variantiVAR_009737583F → S in PAIS. 1 Publication1
Natural variantiVAR_009738583F → Y in PAIS. 1 PublicationCorresponds to variant dbSNP:rs137852587Ensembl.1
Natural variantiVAR_009739583Missing in AIS. 1 Publication1
Natural variantiVAR_009740586R → K in AIS. 1
Natural variantiVAR_009741587A → V in prostate cancer; somatic mutation. 1 Publication1
Natural variantiVAR_009742588A → S in prostate cancer; somatic mutation. 1
Natural variantiVAR_009743597A → T in AIS; abolishes dimerization. 2 PublicationsCorresponds to variant dbSNP:rs137852569Ensembl.1
Natural variantiVAR_009744598S → G in PAIS; associated with P-618 in a PAIS patient; normal androgen binding; does not activate transcription; impairs DNA binding. 1 PublicationCorresponds to variant dbSNP:rs142280455Ensembl.1
Natural variantiVAR_009745598S → T in a patient with severe hypospadias. 1 Publication1
Natural variantiVAR_009746602C → F in AIS. 1 Publication1
Natural variantiVAR_009747605D → Y in PAIS. 1 Publication1
Natural variantiVAR_004684608R → Q in PAIS and breast cancer. 4 PublicationsCorresponds to variant dbSNP:rs137852573Ensembl.1
Natural variantiVAR_004685609R → K in PAIS and breast cancer; defective nuclear localization. 3 PublicationsCorresponds to variant dbSNP:rs137852576Ensembl.1
Natural variantiVAR_009748611N → T in PAIS. 1 Publication1
Natural variantiVAR_009749612C → Y in AIS. 1
Natural variantiVAR_009751616R → H in AIS and PAIS. 4 PublicationsCorresponds to variant dbSNP:rs754201976Ensembl.1
Natural variantiVAR_009752616R → P in AIS. 1
Natural variantiVAR_009750616Missing in AIS. 1 Publication1
Natural variantiVAR_009753617L → P in AIS. 1 Publication1
Natural variantiVAR_009754617L → R in PAIS. 1 Publication1
Natural variantiVAR_009755618R → P in AIS and PAIS; associated with G-598 in a PAIS patient; loss of DNA-binding activity. 2 Publications1
Natural variantiVAR_009756620C → Y in prostate cancer; loss of DNA binding; somatic mutation. 2 Publications1
Natural variantiVAR_009757630R → Q in prostate cancer. 1 Publication1
Natural variantiVAR_009758631K → T in prostate cancer. 1
Natural variantiVAR_004686646A → D1 PublicationCorresponds to variant dbSNP:rs1800053Ensembl.1
Natural variantiVAR_009760648S → N in prostate cancer. Corresponds to variant dbSNP:rs137852584Ensembl.1
Natural variantiVAR_004687665I → N in AIS and PAIS. 1
Natural variantiVAR_009761671Q → R in prostate cancer. 1
Natural variantiVAR_009762672P → H in PAIS. 1
Natural variantiVAR_009763673I → T in prostate cancer. 1
Natural variantiVAR_004688678L → P in AIS. 1 PublicationCorresponds to variant dbSNP:rs137852579Ensembl.1
Natural variantiVAR_009764682E → K in AIS. 2 Publications1
Natural variantiVAR_013474683P → T in PAIS. 1 Publication1
Natural variantiVAR_009765684G → A in prostate cancer. 2 Publications1
Natural variantiVAR_009766685V → I in AIS. 1
Natural variantiVAR_009767687C → R in PAIS. 1
Natural variantiVAR_009768688A → V in PAIS. 1
Natural variantiVAR_009769689G → E in AIS. 1
Natural variantiVAR_009770691Missing in PAIS. 1 Publication1
Natural variantiVAR_004689693Missing in AIS. 1
Natural variantiVAR_004690696D → H in AIS. 1 Publication1
Natural variantiVAR_004691696D → N in AIS; almost complete loss of androgen binding and transcription activation. 2 Publications1
Natural variantiVAR_004692696D → V in AIS. 1 Publication1
Natural variantiVAR_009771701L → M in AIS. 1
Natural variantiVAR_009772702L → F in AIS. 1
Natural variantiVAR_009773702L → H in AIS and prostate cancer. 3 PublicationsCorresponds to variant dbSNP:rs864622007Ensembl.1
Natural variantiVAR_009774703S → A in AIS. 1
Natural variantiVAR_009775704S → C in AIS. 1
Natural variantiVAR_004693704S → G in PAIS and AIS. 1 Publication1
Natural variantiVAR_009776706N → S in AIS. 2 Publications1
Natural variantiVAR_013475706N → Y in AIS. 1 Publication1
Natural variantiVAR_004694708L → R in AIS. 1 PublicationCorresponds to variant dbSNP:rs137852585Ensembl.1
Natural variantiVAR_009777709G → A in PAIS. 2 Publications1
Natural variantiVAR_009778709G → V in AIS. 1
Natural variantiVAR_009779711R → T in AIS. 1
Natural variantiVAR_013476712Q → E in PAIS. 1 Publication1
Natural variantiVAR_009780713L → F in PAIS. Corresponds to variant dbSNP:rs137852595Ensembl.1
Natural variantiVAR_009781716V → M in prostate cancer; gain in function. 1 Publication1
Natural variantiVAR_009782718K → E in prostate cancer. 1
Natural variantiVAR_009783721K → E in prostate cancer; found in bone metastases. 1
Natural variantiVAR_009784722A → T in prostate cancer; somatic mutation. Corresponds to variant dbSNP:rs137852583Ensembl.1
Natural variantiVAR_009785723L → F in AIS. 1
Natural variantiVAR_009786724P → S in AIS. 1
Natural variantiVAR_009787725G → D in AIS and prostate cancer. 1
Natural variantiVAR_009788726F → L in a patient with severe hypospadias. 2 Publications1
Natural variantiVAR_009789727R → L in prostate cancer. 1 PublicationCorresponds to variant dbSNP:rs137852593Ensembl.1
Natural variantiVAR_009790728N → K in AIS. 1 PublicationCorresponds to variant dbSNP:rs768869912Ensembl.1
Natural variantiVAR_009791729L → S in PAIS. 1
Natural variantiVAR_004695731V → M in prostate cancer; increases transcription activation. 3 PublicationsCorresponds to variant dbSNP:rs137852571Ensembl.1
Natural variantiVAR_004696733D → N in AIS. 1 Publication1
Natural variantiVAR_004697733D → Y in AIS. 1
Natural variantiVAR_009792734Q → H in PAIS. 1
Natural variantiVAR_009793738I → T in PAIS. 1 Publication1
Natural variantiVAR_009794742W → R in AIS. 1 Publication1
Natural variantiVAR_004698743M → I in PAIS. 1 Publication1
Natural variantiVAR_009795743M → V in PAIS. 1 Publication1
Natural variantiVAR_013477744G → E in AIS. 1 PublicationCorresponds to variant dbSNP:rs137852600Ensembl.1
Natural variantiVAR_004699744G → V in PAIS and AIS. 4 PublicationsCorresponds to variant dbSNP:rs137852600Ensembl.1
Natural variantiVAR_009796745L → F in AIS and prostate cancer. 1
Natural variantiVAR_009797746M → T in PAIS. 1 Publication1
Natural variantiVAR_009798747V → M in PAIS. 1
Natural variantiVAR_009799749A → D in PAIS. 1
Natural variantiVAR_009800749A → T in prostate cancer. 1
Natural variantiVAR_009801749A → V in prostate cancer. 1
Natural variantiVAR_009802750M → I in prostate cancer. 1
Natural variantiVAR_004700750M → V in PAIS and AIS. 3 Publications1
Natural variantiVAR_004701751G → D in AIS; loss of androgen binding. 1 Publication1
Natural variantiVAR_009803751G → S in prostate cancer. 1
Natural variantiVAR_009804752W → R in AIS. 1
Natural variantiVAR_004702753R → Q in AIS. 2 Publications1
Natural variantiVAR_009805755F → L in PAIS and prostate cancer. 2 Publications1
Natural variantiVAR_004703755F → V in AIS. 2 Publications1
Natural variantiVAR_009806756T → A in prostate cancer. 1
Natural variantiVAR_009807757N → S in PAIS. Corresponds to variant dbSNP:rs141425171Ensembl.1
Natural variantiVAR_009808758V → A in prostate cancer. 1 Publication1
Natural variantiVAR_009809759N → T in PAIS; 50% reduction in transactivation. 1 Publication1
Natural variantiVAR_009810760S → F in AIS. 1 Publication1
Natural variantiVAR_009811760S → P in prostate cancer. 1
Natural variantiVAR_004704763L → F in AIS; loss of androgen binding. 1 Publication1
Natural variantiVAR_004705764Y → C in PAIS and prostate cancer; partial loss of androgen binding. 3 PublicationsCorresponds to variant dbSNP:rs137852567Ensembl.1
Natural variantiVAR_009812764Y → H in AIS. 1 Publication1
Natural variantiVAR_009813765F → L in AIS. 1 Publication1
Natural variantiVAR_004707766A → T in AIS; loss of androgen binding. 4 Publications1
Natural variantiVAR_009814766A → V in AIS. 1
Natural variantiVAR_009815767P → S in AIS. 1
Natural variantiVAR_009816768D → E in AIS. 1 Publication1
Natural variantiVAR_009817769L → P in AIS. 1
Natural variantiVAR_009818772N → H in PAIS. 1 Publication1
Natural variantiVAR_009819773E → A in PAIS. 1 Publication1
Natural variantiVAR_009820773E → G in PAIS. 1 Publication1
Natural variantiVAR_004709775R → C in AIS; frequent mutation; loss of androgen binding. 5 PublicationsCorresponds to variant dbSNP:rs137852562Ensembl.1
Natural variantiVAR_004708775R → H in AIS and PAIS; almost complete loss of androgen binding. 4 PublicationsCorresponds to variant dbSNP:rs137852572Ensembl.1
Natural variantiVAR_004710780R → W in AIS. 3 Publications1
Natural variantiVAR_004711781M → I in PAIS and AIS. 3 PublicationsCorresponds to variant dbSNP:rs137852589Ensembl.1
Natural variantiVAR_009821783S → N in prostate cancer; somatic mutation. 1
Natural variantiVAR_004712785C → Y in AIS; loss of androgen binding and of transactivation. 1 Publication1
Natural variantiVAR_004713788M → V in AIS. 1 PublicationCorresponds to variant dbSNP:rs137852570Ensembl.1
Natural variantiVAR_009822789R → S in AIS. 1
Natural variantiVAR_009823791L → F in AIS. 1 Publication1
Natural variantiVAR_009824792S → P in prostate cancer. 1
Natural variantiVAR_009825794E → D1 Publication1
Natural variantiVAR_004714795F → S in AIS. 1 Publication1
Natural variantiVAR_004715799Q → E in PAIS, AIS and prostate cancer; reduced transcription activation. 6 PublicationsCorresponds to variant dbSNP:rs137852591Ensembl.1
Natural variantiVAR_009826807C → Y in PAIS. 1
Natural variantiVAR_004716808M → R in AIS; loss of transactivation. 1 Publication1
Natural variantiVAR_009827808M → T in PAIS. 1 PublicationCorresponds to variant dbSNP:rs137852592Ensembl.1
Natural variantiVAR_004717808M → V in AIS; 25% androgen binding. 1 Publication1
Natural variantiVAR_009828813L → F in AIS. 1 Publication1
Natural variantiVAR_004718815S → N in AIS and PAIS. 1
Natural variantiVAR_009829821G → A in AIS. 1 Publication1
Natural variantiVAR_009830822L → V in PAIS. 1
Natural variantiVAR_013478828F → V in PAIS. 1 Publication1
Natural variantiVAR_009831831L → P in prostate cancer. 1
Natural variantiVAR_004719832R → L in AIS. 1 Publication1
Natural variantiVAR_004720832R → Q in AIS; loss of androgen binding. 3 Publications1
Natural variantiVAR_009832835Y → C in AIS; loss of androgen binding. 1 Publication1
Natural variantiVAR_004721841R → C in AIS. 3 PublicationsCorresponds to variant dbSNP:rs137852577Ensembl.1
Natural variantiVAR_004722841R → G in PAIS. 1 Publication1
Natural variantiVAR_004723841R → H in AIS. 7 PublicationsCorresponds to variant dbSNP:rs9332969Ensembl.1
Natural variantiVAR_009229841R → S in PAIS. 1 Publication1
Natural variantiVAR_009833842I → S in PAIS. 1
Natural variantiVAR_004724843I → T in AIS. 2 PublicationsCorresponds to variant dbSNP:rs9332970Ensembl.1
Natural variantiVAR_009834847R → G in prostate cancer. 1 Publication1
Natural variantiVAR_009835855R → K in PAIS. 1
Natural variantiVAR_004725856R → C in AIS. 5 Publications1
Natural variantiVAR_004726856R → H in AIS; strongly reduced transcription activation. 5 PublicationsCorresponds to variant dbSNP:rs9332971Ensembl.1
Natural variantiVAR_009836857F → L in AIS. Corresponds to variant dbSNP:rs137852598Ensembl.1
Natural variantiVAR_009837864L → R in AIS. 1
Natural variantiVAR_009838865D → G in AIS. 1 Publication1
Natural variantiVAR_004727865D → N in AIS; loss of androgen binding. 1 Publication1
Natural variantiVAR_009839866S → P in AIS. Corresponds to variant dbSNP:rs137852597Ensembl.1
Natural variantiVAR_004728867V → E in AIS. 1
Natural variantiVAR_004729867V → L in PAIS. 3 PublicationsCorresponds to variant dbSNP:rs137852564Ensembl.1
Natural variantiVAR_004730867V → M in AIS and prostate cancer. 4 PublicationsCorresponds to variant dbSNP:rs137852564Ensembl.1
Natural variantiVAR_004731870I → M in PAIS. 2 PublicationsCorresponds to variant dbSNP:rs137852574Ensembl.1
Natural variantiVAR_009840871A → G in PAIS. 1 Publication1
Natural variantiVAR_009841871A → V in PAIS. 1 PublicationCorresponds to variant dbSNP:rs143040492Ensembl.1
Natural variantiVAR_009842872R → G in AIS. 1 Publication1
Natural variantiVAR_013479875H → R in AIS. 1 Publication1
Natural variantiVAR_009843875H → Y in prostate cancer; increases affinity for testosterone and androgen sensitivity; increased transcription activation. 1 PublicationCorresponds to variant dbSNP:rs137852581Ensembl.1
Natural variantiVAR_004732878T → A in prostate cancer; found in bone metastases; alters receptor specificity so that transcription is activated by antiandrogens such as cyproterone acetate. 9 PublicationsCorresponds to variant dbSNP:rs137852578Ensembl.1
Natural variantiVAR_009844878T → S in prostate cancer. Corresponds to variant dbSNP:rs137852580Ensembl.1
Natural variantiVAR_013480880D → Y in AIS. 1 Publication1
Natural variantiVAR_009845881L → Q in prostate cancer. 1
Natural variantiVAR_009846882L → V in AIS. 1 Publication1
Natural variantiVAR_009847887M → V in AIS. Corresponds to variant dbSNP:rs755226547Ensembl.1
Natural variantiVAR_009848890V → M in AIS and PAIS. 2 Publications1
Natural variantiVAR_009849891D → N in prostate cancer. 1 Publication1
Natural variantiVAR_009850892F → L in prostate cancer. 1
Natural variantiVAR_004733893P → L in AIS. 3 Publications1
Natural variantiVAR_004734896M → T in AIS; low androgen binding and transactivation. 2 Publications1
Natural variantiVAR_009851897A → T in prostate cancer. 1
Natural variantiVAR_009852899I → T in AIS. 1
Natural variantiVAR_009853903Q → R in prostate cancer. Corresponds to variant dbSNP:rs137852582Ensembl.1
Natural variantiVAR_009854904V → M in PAIS. 1
Natural variantiVAR_009855905P → H in AIS. 1
Natural variantiVAR_009856905P → S in AIS. 1
Natural variantiVAR_004735908L → F in AIS; almost complete loss of transcription activation. 2 Publications1
Natural variantiVAR_009857910G → E in prostate cancer. 1
Natural variantiVAR_009858910G → R in PAIS. 1 Publication1
Natural variantiVAR_009859911K → R in prostate cancer. 1 Publication1
Natural variantiVAR_009860912V → L in PAIS. 1 Publication1
Natural variantiVAR_004736914P → S in PAIS. 1
Natural variantiVAR_009861917F → L in AIS. 1 Publication1
Natural variantiVAR_009862918H → R in AIS. 1
Natural variantiVAR_009863920Q → R in prostate cancer. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0368891 – 532Missing in isoform 2. CuratedAdd BLAST532
Alternative sequenceiVSP_036890533 – 539GPYGDMR → MILWLHS in isoform 2. Curated7
Alternative sequenceiVSP_058166629 – 644ARKLK…LQEEG → EKFRVGNCKHLKMTRP in isoform 3. Add BLAST16
Alternative sequenceiVSP_058167630 – 648RKLKK…GEASS → AVVVSERILRVFGVSEWLP in isoform 4. Add BLAST19
Alternative sequenceiVSP_058168645 – 920Missing in isoform 3. Add BLAST276
Alternative sequenceiVSP_058169649 – 920Missing in isoform 4. Add BLAST272

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20132 mRNA. Translation: AAA51729.1.
M23263 mRNA. Translation: AAA51775.1.
M27430
, M27423, M27424, M27425, M27426, M27427, M27428, M27429 Genomic DNA. Translation: AAA51886.1.
M34233 mRNA. Translation: AAA51780.1.
M21748 mRNA. Translation: AAA51771.1.
M35851
, M35844, M35845, M35846, M35847, M35848, M35849, M35850 Genomic DNA. Translation: AAA51772.1.
AX453758 Unassigned DNA. No translation available.
FJ235916 mRNA. Translation: ACN39559.1.
FJ235917 mRNA. Translation: ACN39560.1.
AL049564, AL158016, AL356358 Genomic DNA. Translation: CAI43080.1.
AL158016, AL049564, AL356358 Genomic DNA. Translation: CAI40853.1.
AL356358, AL049564, AL158016 Genomic DNA. Translation: CAI40496.1.
CH471132 Genomic DNA. Translation: EAX05380.1.
BC132975 mRNA. Translation: AAI32976.1.
L29496 mRNA. Translation: AAA51770.1.
U16371 Genomic DNA. Translation: AAB60346.1.
M20260 mRNA. Translation: AAA51774.1.
S79366 Genomic DNA. Translation: AAB21256.2.
S79366 Genomic DNA. Translation: AAB21257.2.
CCDSiCCDS14387.1. [P10275-1]
CCDS43965.1. [P10275-2]
PIRiA39248.
RefSeqiNP_000035.2. NM_000044.4. [P10275-1]
NP_001011645.1. NM_001011645.3. [P10275-2]
NP_001334990.1. NM_001348061.1. [P10275-3]
NP_001334992.1. NM_001348063.1. [P10275-4]
NP_001334993.1. NM_001348064.1.
UniGeneiHs.76704.

Genome annotation databases

EnsembliENST00000374690; ENSP00000363822; ENSG00000169083. [P10275-1]
ENST00000396043; ENSP00000379358; ENSG00000169083. [P10275-2]
ENST00000504326; ENSP00000421155; ENSG00000169083. [P10275-3]
GeneIDi367.
KEGGihsa:367.
UCSCiuc004dwv.3. human. [P10275-1]
uc011mpf.2. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism, Triplet repeat expansion

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiANDR_HUMAN
AccessioniPrimary (citable) accession number: P10275
Secondary accession number(s): A0A0B4J1T2
, A2RUN2, B1AKD7, C0JKD3, C0JKD4, E7EVX6, Q9UD95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: March 16, 2016
Last modified: July 5, 2017
This is version 252 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families