or pharmaceutically acceptable salts thereof; wherein

W is

A¹ and A⁴ are independently C;

each A² and A³ is C;

B and C are independently an optionally substituted 5-7 membered carbocyclic ring, aryl, heteroaryl or heterocyclic ring containing N, O or S;

Z¹, Z² and Z³ are independently NR¹¹, C═O, CR—OR, (CR₂)_1-2 or ═C—R¹²;

R¹ is halo or C_1-6 alkyl;

R² is H;

R³ is SO₂R¹² or cyano;

R⁴, R⁷ and R¹⁰ are independently H;

R, R⁵ and R^5′ are independently H or C_1-6 alkyl;

R⁶ is —OR¹²;

one of R⁸ and R⁹ is (CR₂)_qY and the other is C_1-6 alkyl;

R¹¹ is H, C_1-6 alkyl, C_2-6 alkenyl, (CR₂)_pCO_1-2R, (CR₂)_pOR, (CR₂)_pR¹³, (CR₂)_pNRR¹², (CR₂)_pCONRR¹² or (CR₂)_pSO_1-2R¹²;

R¹² and R¹³ are independently an optionally substituted 3-7 membered saturated or partially unsaturated carbocyclic ring, or a 5-7 membered heterocyclic ring comprising N, O and/or S; aryl or heteroaryl; or R¹² is H or C_1-6 alkyl;

Y is an optionally substituted 3-12 membered carbocyclic ring, a 5-12 membered aryl, or a 5-12 membered heteroaryl comprising N, O and/or S and attached to A² or A³ or both via a carbon atom of said heteroaryl

n is 4;

p is 0-4; and

q is 0.

R⁵ and R^5′ are H.

or pharmaceutically acceptable salts thereof;

wherein R¹ is halo or C_1-6 alkyl;

R² is H;

R⁶ is isopropoxy or methoxy;

Y is an optionally substituted C_3-7 cycloalkyl, C_3-7 cycloalkenyl, or phenyl; or Y is pyridyl, pyrazolyl, isoxazolyl, imidazolyl, thiazolyl, or benzimidazolyl, each of which is attached to the phenyl ring via a carbon atom; and

R³, R⁴, R⁸, R⁹ and n are as defined in claim 1.

wherein B and C together form

Z¹, Z² and Z³ together form

R¹ is halo or C_1-6 alkyl;

R² is H; and

R⁶ is isopropoxy or methoxy.

R and R¹² are independently H or C_1-6 alkyl; and

R¹³ is an optionally substituted piperidinyl, azetidiyl, tetrahydropyranyl, cyclohexyl, morpholinyl, pyrrolidinyl, heptamethyleneimine, octamethyleneimine, a bicyclic amine or diamine derivative, quinuclidin-3-yl, 8-methyl-8-aza-bicyclo[3.2.1]oct-6-yl], or 9-methyl-9-aza-bicyclo[4.2.1]nonan-7-yl.

or a pharmaceutically acceptable salt thereof.

or a pharmaceutically acceptable salt thereof.

or pharmaceutically acceptable salts thereof.