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Case Report
Interstitial Pneumonitis Associated with Infliximab Therapy
EDITH VILLENEUVE, ANNE ST-PIERRE, and BOULOS HARAOUI ABSTRACT. Interstitial pneumonitis is a well documented, rare complication of methotrexate (MTX). We describe a patient with rheumatoid arthritis (RA) taking MTX for more than 3 years who then developed severe interstitial pneumonitis after a third infliximab infusion. Other similar cases are reviewed. Infliximab may potentiate pulmonary toxicity of MTX. (First Release April 15 2006; J Rheumatol 2006;33:1189–93) Key Indexing Terms:
PNEUMONITIS
From the Department of Rheumatology, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada. E. Villeneuve, MD, Rheumatology Trainee; A. St-Pierre, MD, Professor, Department of Rheumatology; B. Haraoui, MD, Professor, Department of Rheumatology. Address reprint requests to Dr. B. Haraoui, Department of Rheumatology, Centre Hospitalier de l'Université de Montréal, Hôpital Notre-Dame, 1560 Sherbrooke Est, Montréal, Québec H2L 4M1, Canada. Accepted for publication January 13, 2006.
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