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    Pharmaceuticals Inc., makers of:    Xiaflex

    XIAFLEX® is a prescription medicine used to treat adults with Dupuytren's contracture when a "cord" can be felt

    Dupuytren's contracture can have an impact on your ability to straighten your affected fingers

    This content is from our sponsor. The sponsor has sole editorial control.

    "I can't straighten my fingers because I have Dupuytren's contracture."

    THERE'S A NONSURGICAL TREATMENT OPTION THAT COULD HELP ADULTS WITH A DUPUYTREN'S "CORD" THAT CAN BE FELT

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    Since 2010, it is estimated that more than 80,000 patients with Dupuytren's contracture have been treated with XIAFLEX® through June 2016.

    The facts about Dupuytren's contracture

    Dupuytren's contracture: What to look for

    • Rope-like "cord" can form in the palm
    • One or more fingers can gradually pull inward
    • Changes begin to impact amount you can straighten or move your fingers

    Dupuytren's contracture is a progressive hand condition that affects how much you can move or straighten your fingers. It is caused by an abnormal buildup of a substance called collagen.

    • An abnormal buildup of a substance called collagen can cause a rope-like cord to form in the palm
    • Over time, the cord may thicken and shorten, causing one or more fingers to gradually pull inward. This bending of the fingers is called contracture
    • The most commonly affected joints are the metacarpophalangeal (MP) joint (where the palm meets the hand) and the proximal interphalangeal (PIP) joint (knuckle) in the ring finger and the little finger
    • The contracture may also occur in other fingers and joints, but this is less common

    Different people experience Dupuytren's contracture in different ways, and the condition may continue to worsen over time. Although there is no cure, there is treatment available for adults with Dupuytren's contracture with a "cord" that can be felt.

    About XIAFLEX® Treatment

    XIAFLEX® is a prescription medicine used to treat adults with Dupuytren's contracture when a "cord" can be felt. XIAFLEX® is injected directly into the "cord" that is causing your finger to be bent. No hand surgery is required to administer XIAFLEX®, and the procedure can be performed in-office without general anesthesia. If you have more than 1 contracture, your healthcare provider may give you 2 injections in 1 of your hands during your visit. XIAFLEX® should be injected into a cord by a healthcare provider who is experienced in injection procedures of the hand and treating people with Dupuytren's contracture. XIAFLEX® can cause serious side effects, such as tendon rupture or ligament damage.

    Ask your doctor about a nonsurgical treatment option.

    WHAT IS XIAFLEX®?

    XIAFLEX® is a prescription medicine used to treat adults with Dupuytren's contracture when a "cord" can be felt. It is not known if XIAFLEX® is safe and effective in children under the age of 18.

    IMPORTANT SAFETY INFORMATION FOR XIAFLEX®

    Do not receive XIAFLEX® if you have had an allergic reaction to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX®, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX®.

    XIAFLEX® can cause serious side effects, including:

    • Tendon rupture or ligament damage. Receiving an injection of XIAFLEX® may cause damage to a tendon or ligament in your hand and cause it to break or weaken. This could require surgery to fix the damaged tendon or ligament. Call your healthcare provider right away if you have trouble bending your injected finger (towards the wrist) after the swelling goes down or you have problems using your treated hand after your follow-up visit
    • Nerve injury or other serious injury of the hand. Call your healthcare provider right away if you get numbness, tingling, increased pain, or tears in the skin (laceration) in your treated finger or hand after your injection or after your follow-up visit
    • Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions can happen in people who receive XIAFLEX® because it contains foreign proteins. Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX®:
      • hives
      • swollen face
      • breathing trouble
      • chest pain
      • low blood pressure
      • dizziness or fainting
    • Increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX®. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX® may not be right for you.

    Before receiving XIAFLEX®, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX® injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Using XIAFLEX® with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX® injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure.

    The most common side effects with XIAFLEX® for the treatment of Dupuytren's contracture include:

    • swelling of the injection site or the hand
    • bruising or bleeding at the injection site
    • pain or tenderness of the injection site or the hand
    • swelling of the lymph nodes (glands) in the elbow or armpit
    • itching
    • breaks in the skin
    • redness or warmth of the skin
    • pain in the armpit

    Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects with XIAFLEX®. For more information, ask your healthcare provider or pharmacist.

    Please see the full Prescribing Information, including Medication Guide.

    The information on this website should not take the place of talking with your doctor. If you have any questions, talk to your doctor or pharmacist.

    This product information is intended for U.S. residents only.

    Rx Only

    XIAFLEX® is a registered trademark of Endo International plc or one of its affiliates.

    © 2017 Endo Pharmaceuticals Inc. All rights reserved. Malvern, PA 19355

    XD-05030/January 2017 www.xiaflex.com 1-800-462-ENDO (3636)

    WebMD does not endorse any specific product, service, or treatment.

    Important Safety Information | Full Prescribing Information | Medication Guide

    IMPORTANT SAFETY INFORMATION FOR XIAFLEX®

    Do not receive XIAFLEX® if you have had an allergic reaction to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX®, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX®.

    XIAFLEX® can cause serious side effects, including:

    • Tendon rupture or ligament damage. Receiving an injection of XIAFLEX® may cause damage to a tendon or ligament in your hand and cause it to break or weaken. This could require surgery to fix the damaged tendon or ligament. Call your healthcare provider right away if you have trouble bending your injected finger (towards the wrist) after the swelling goes down or you have problems using your treated hand after your follow-up visit
    • Nerve injury or other serious injury of the hand. Call your healthcare provider right away if you get numbness, tingling, increased pain, or tears in the skin (laceration) in your treated finger or hand after your injection or after your follow-up visit
    • Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions can happen in people who receive XIAFLEX® because it contains foreign proteins. Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX®:
      • hives
      • swollen face
      • breathing trouble
      • chest pain
      • low blood pressure
      • dizziness or fainting
    • Increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX®. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX® may not be right for you.

    Before receiving XIAFLEX®, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX® injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Using XIAFLEX® with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX® injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure.

    The most common side effects with XIAFLEX® for the treatment of Dupuytren's contracture include:

    • swelling of the injection site or the hand
    • bruising or bleeding at the injection site
    • pain or tenderness of the injection site or the hand
    • swelling of the lymph nodes (glands) in the elbow or armpit
    • itching
    • breaks in the skin
    • redness or warmth of the skin
    • pain in the armpit

    Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects with XIAFLEX®. For more information, ask your healthcare provider or pharmacist.

    WHAT IS XIAFLEX®?

    XIAFLEX® is a prescription medicine used to treat adults with Dupuytren's contracture when a "cord" can be felt. It is not known if XIAFLEX® is safe and effective in children under the age of 18.

    Please see the full Prescribing Information, including Medication Guide.

    The information on this website should not take the place of talking with your doctor. If you have any questions, talk to your doctor or pharmacist.

    This product information is intended for U.S. residents only.

    Rx Only

    XIAFLEX® is a registered trademark of Endo International plc or one of its affiliates.

    © 2017 Endo Pharmaceuticals Inc.

    All rights reserved. Malvern, PA 19355

    XD-05030/January 2017 www.xiaflex.com 1-800-462-ENDO (3636)