9758/3 Follicular dendritic cell tumor
Definitions
| Tumours of haematopoietic and lymphoid tissues | ||
| ICD-O-3 topography code: | C42 and C77 | |
| ICD10: | D47.7 | |
/span>ollicular dendritic cell (FDC) sarcoma is a neoplastic proliferation of spindled to ovoid cells showing morphologic and immunophenotypic features of follicular dendritic cells.
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| Thyroid gland | ||
| ICD-O-3 topography code: | C73 | |
| ICD10: | C96.4 | |
Follicular dendritic cell sarcoma is a rare neoplasm composed of spindle to ovoid cells that have morphologic and immunophenotypic characteristics of follicular dendritic cells. It affects lymph nodes and other sites including the tonsils, gastrointestinal tract, spleen, liver, soft tissues, skin, and oral cavity. It may be associated with Castelman disease, preferentially affects adults and behaves as a low grade sarcoma. Treatment options include complete surgical removal of the tumor with or without adjuvant chemotherapy or radiotherapy 3
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008
The inflammatory pseudo-tumourlike variant of follicular dendritic cell sarcoma affects predominantly females and is consistently associated with Epstein-Barr virus (EBV), with EBVencoded RNA (EBER) being present in virtually all neoplastic spindle cells 4
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008
Primary follicular dendritic cell tumours of the thyroid are exceptionally rare and the few reported cases have occured in adults5
World Health Organization Classification of Tumours. Pathology and Genetics of Tumors of Endocrine Organs
IARC Press: Lyon 2004
| Click to access Pubmed |
Dendritic cell sarcoma of the thyroid.
Head Neck 21: 273-5
| Lip, Oral Cavity and Oropharynx | ||
| ICD-O-3 topography code: | C00-C06, C09-C10, C14 | |
| ICD10: | C96.4 | |
Follicular dendritic cell sarcoma is a rare neoplasm composed of spindle to ovoid cells that have morphologic and immunophenotypic characteristics of follicular dendritic cells. It affects lymph nodes and other sites including the tonsils, gastrointestinal tract, spleen, liver, soft tissues, skin, and oral cavity. It may be associated with Castelman disease, preferentially affects adults and behaves as a low grade sarcoma. Treatment options include complete surgical removal of the tumor with or without adjuvant chemotherapy or radiotherapy 7
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008
The inflammatory pseudo-tumourlike variant of follicular dendritic cell sarcoma affects predominantly females and is consistently associated with Epstein-Barr virus (EBV), with EBVencoded RNA (EBER) being present in virtually all neoplastic spindle cells 8
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008
| Thymus | ||
| ICD-O-3 topography code: | C37 | |
| ICD10: | D47.7 | |
Follicular dendritic cell sarcoma is a rare neoplasm composed of spindle to ovoid cells that have morphologic and immunophenotypic characteristics of follicular dendritic cells. It affects lymph nodes and other sites including the tonsils, gastrointestinal tract, spleen, liver, soft tissues, skin, and oral cavity. It may be associated with Castelman disease, preferentially affects adults and behaves as a low grade sarcoma. Treatment options include complete surgical removal of the tumor with or without adjuvant chemotherapy or radiotherapy 9
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008
The inflammatory pseudo-tumourlike variant of follicular dendritic cell sarcoma affects predominantly females and is consistently associated with Epstein-Barr virus (EBV), with EBVencoded RNA (EBER) being present in virtually all neoplastic spindle cells 10
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008
| Nasopharynx | ||
| ICD-O-3 topography code: | C11 | |
| ICD10: | C96.4 | |
Follicular dendritic cell sarcoma is a rare neoplasm composed of spindle to ovoid cells that have morphologic and immunophenotypic characteristics of follicular dendritic cells. It affects lymph nodes and other sites including the tonsils, gastrointestinal tract, spleen, liver, soft tissues, skin, and oral cavity. It may be associated with Castelman disease, preferentially affects adults and behaves as a low grade sarcoma. Treatment options include complete surgical removal of the tumor with or without adjuvant chemotherapy or radiotherapy 11
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008
The inflammatory pseudo-tumourlike variant of follicular dendritic cell sarcoma affects predominantly females and is consistently associated with Epstein-Barr virus (EBV), with EBVencoded RNA (EBER) being present in virtually all neoplastic spindle cells 12
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008