8890/0 Lipoleiomyoma
Definitions
| Tumours of the central nervous system | ||
| ICD-O-3 topography code: | C70, C71 and C72 | |
Leiomyoma is a well-circumscribed benign smooth muscle neoplasm histologically characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.
| Esophagus | ||
| ICD-O-3 topography code: | C15 | |
/span>eiomyoma is a well-circumscribed benign smooth muscle neoplasm histologically characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.
In the oesophagus, leiomyoma is the most common mesenchymal tumour and occurs over a wide range of ages from childhood onwards and is twice as frequent in males as in females 1
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010
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Tumors of the esophagus.
World J Surg 24: 401-11
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Esophageal stromal tumors: a clinicopathologic, immunohistochemical, and molecular genetic study of 17 cases and comparison with esophageal leiomyomas and leiomyosarcomas.
Am J Surg Pathol 24: 211-22
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Leiomyomata of the esophagus. An analysis of 838 cases.
Cancer 38: 2166-77
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| Stomach | ||
| ICD-O-3 topography code: | C16 | |
Leiomyoma is a well-circumscribed benign smooth muscle neoplasm histologically characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.
Gastric intramural leiomyoma
This tumour is rare, approximately 50 times less common than gastrointestinal stromal tumor (GIST). These tumours usually occur in older adults and clinically present similarly to GISTs. The tumours vary from minimal mural nodules to masses of >5cm in size. However, minimal leiomyomas have been commonly found in oesophagogastric resections for carcinoma 7
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"Seedling" mesenchymal tumors (gastrointestinal stromal tumors and leiomyomas) are common incidental tumors of the esophagogastric junction.
Am J Surg Pathol 31: 1629-35
Smooth-muscle tumours with atypia and mitotic activity are designated leiomyosarcoma, and such tumours are distinctly rare in the stomach.
| Colon and rectum | ||
| ICD-O-3 topography code: | C18-C20 | |
Leiomyoma is a well-circumscribed benign smooth muscle neoplasm histologically characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.
Leiomyoma of the colon and rectum
A distinctive type of leiomyoma that usually occurs in the colon and rectum is that of the muscularis mucosae. These tumours are roundish nodules that usually measure < 1 cm and not more than 2 cm. They are usually incidental endoscopic findings in older adults and are clinically indolent. Histologically, these tumours are composed of bundles of well-differentiated smooth muscle that merge into the muscularis mucosae. Although focal nuclear atypia may be present, mitotic activity is not detectable.
Intramural leiomyomas are rare. They usually measure 1?3 cm, and are composed of well-differentiated smooth muscle cells with limited, if any, atypia and virtually no mitotic activity, although tumours with both atypia and mitotic activity are more appropriately designated as leiomyosarcomas8
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010
| Hypopharynx, Larynx and Trachea | ||
| ICD-O-3 topography code: | C13, C32, C33 | |
Leiomyoma is a well-circumscribed benign smooth muscle neoplasm histologically characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.
| Breast | ||
| ICD-O-3 topography code: | C50 | |
Leiomyoma and leiomyosarcoma are, respectively, morphologically benign and malignant tumours that show distinct smooth-muscle differentiation.
| Skin | ||
| ICD-O-3 topography code: | C44 | |
Leiomyoma is a well-circumscribed benign smooth muscle neoplasm histologically characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.
Skin: Pilar leiomyoma
| Kidney | ||
| ICD-O-3 topography code: | C64 | |
Leiomyoma is a well-circumscribed, benign smooth muscle neoplasm histologically characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern 10
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002
Renal leiomyomas commonly arise from the renal capsule, but also from the muscularis of the renal pelvis or from cortical vascular smooth muscle. The tumours are firm, solid, and usually small. Most are incidentally discovered at autopsy 11
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs.
3rd Edition
IARC Press: Lyon 2004
| Connective, subcutaneous and other soft tissues | ||
| ICD-O-3 topography code: | C49 | |
/span>eiomyoma is a well-circumscribed benign smooth muscle neoplasm histologically characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern 12
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs.
3rd Edition
IARC Press: Lyon 2004
> Press: Lyon 2002
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002
| Corpus uteri | ||
| ICD-O-3 topography code: | C54 | |
Leiomyoma is a well-circumscribed benign smooth muscle neoplasm histologically characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern. Scattered adipocytes are a relatively common observation; a leiomyoma containing a striking number of adipocytes is termed a lipoleiomyoma.
Leiomyomas of the uterine corpus arise from the myometrium. They typically present as multiple, spherical firm nodules. Most frequently, they are intramural. Submucosal leiomyomas deform the overlying endometrium and may bulge into the endometrial cavity. They are frequently ulcerated and haemorrhagic. Subserosal leiomyomas can become pedunculated and may lose their attachment to the uterus. Degenerative changes are common. Most tumours are more cellular than the surrounding myometrium15
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003
| Small intestine | ||
| ICD-O-3 topography code: | C17 | |
Leiomyoma is a well-circumscribed benign smooth muscle neoplasm histologically characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.
Intestinal leiomyoma
Intramural leiomyomas similar to those seen in the stomach are very rare (about 1 per 100 gastrointestinal stromal tumors (GISTs)). Muscularis mucosae leiomyoma, like that found more commonly in the colon and rectum, has also been reported16
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010
| Gallbladder and extrahepatic biliary tract | ||
| ICD-O-3 topography code: | C23-C24.0 | |
Leiomyoma is a well-circumscribed benign smooth muscle neoplasm histologically characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.
| Cervix uteri | ||
| ICD-O-3 topography code: | C53 | |
Leiomyoma is a well-circumscribed benign smooth muscle neoplasm histologically characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.
Leiomyoma is the most common benign mesenchymal tumour of the cervix17
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003
| Urinary system: Renal pelvis, ureter, bladder, urethra | ||
| ICD-O-3 topography code: | C65-C68 | |
Leiomyoma is a well-circumscribed benign smooth muscle neoplasm histologically characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.
| Nasal cavity and Sinuses | ||
| ICD-O-3 topography code: | C30-C31 | |
Leiomyoma is a well-circumscribed benign smooth muscle neoplasm histologically characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.
| Prostate gland | ||
| ICD-O-3 topography code: | C61 | |
Leiomyoma is a well-circumscribed benign smooth muscle neoplasm histologically characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.
| Vagina | ||
| ICD-O-3 topography code: | C52 | |
Leiomyoma is a well-circumscribed benign smooth muscle neoplasm histologically characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.
| Fallopian tube and Uterine ligaments | ||
| ICD-O-3 topography code: | C57 | |
Leiomyoma is a well-circumscribed benign smooth muscle neoplasm histologically characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.
| Bone | ||
| ICD-O-3 topography code: | C40-C41 | |
Leiomyoma is a well-circumscribed benign smooth muscle neoplasm histologically characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.
| Vulva | ||
| ICD-O-3 topography code: | C51 | |
Leiomyoma is a well-circumscribed benign smooth muscle neoplasm histologically characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.