Everything past level 61, really. The difference between levels 70, 71, and 72 are already extreme as-is. OP levels just made it even more extreme.
Mods have since made the level scaling a lot more tolerable, and Slag a lot less of a requirement to enjoy the endgame combat, but Gearbox didn't do a damn thing to Borderlands 2 VR, so I'm not confident they'll try to do anything new here, either.