Aliases for KRT73 Gene
Aliases for KRT73 Gene
External Ids for KRT73 Gene
- HGNC: 28928
- Entrez Gene: 319101
- Ensembl: ENSG00000186049
- OMIM: 608247
- UniProtKB: Q86Y46
Previous GeneCards Identifiers for KRT73 Gene
- GC12M051288
- GC12M053001
- GC12M050045
Summaries for KRT73 Gene
-
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]
GeneCards Summary for KRT73 Gene
KRT73 (Keratin 73) is a Protein Coding gene. Among its related pathways are Developmental Biology and Keratinization. Gene Ontology (GO) annotations related to this gene include structural molecule activity.
UniProtKB/Swiss-Prot for KRT73 Gene
-
Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).
Additional gene information for KRT73 Gene
- Monarch Initiative
- Search for KRT73 at DataMed
- Search for KRT73 at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT73 Gene
Genomics for KRT73 Gene
GeneHancer (GH) Regulatory Elements for KRT73 Gene
Promoters and enhancers for KRT73 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH12J052630 | Promoter/Enhancer | 1.1 | EPDnew ENCODE dbSUPER | 558.2 | -10.7 | -10743 | 0.4 | ZNF707 HLF | KRT73 LOC105369772 KRT72 ENSG00000257605 HNRNPA3P10 ATG101 GC12P052549 | |
| GH12J052579 | Enhancer | 1 | FANTOM5 ENCODE | 6.8 | +38.7 | 38671 | 3.7 | RAD21 SP1 PRDM1 ZIC2 CTCF RXRA SP7 REST ZBTB8A PRDM10 | KRT72 KRT1 KRT71 KRT78 KRT79 KRT2 KRT84 KRT4 KRT6C KRT76 | |
| GH12J052583 | Enhancer | 0.7 | ENCODE | 6.9 | +36.7 | 36718 | 0.1 | SP1 RAD21 RXRA REST ZBTB8A PRDM10 ARID2 TRIM22 CTCF SCRT2 | KRT1 KRT78 KRT84 KRT2 KRT73 KRT74 KRT73-AS1 GC12P052549 | |
| GH12J052626 | Enhancer | 0.5 | dbSUPER | 5.4 | -7.0 | -6957 | 1.6 | MNT ZNF766 GABPA NR2C2 SIX4 ZNF701 ELF1 | KRT72 PCBP2 HNRNPA3P10 SP1 AAAS ATF7 LOC100652999 ZNF740 KRT73 ENSG00000257475 | |
| GH12J052609 | Enhancer | 0.4 | ENCODE dbSUPER | 6.8 | +9.9 | 9943 | 1.9 | KRT72 KRT2 KRT71 KRT78 KRT76 KRT79 KRT73 GC12P052616 KRT73-AS1 GC12P052549 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around KRT73 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the KRT73 gene promoter:
-
- AML1a
- C/EBPalpha
- CHOP-10
- E47
- IRF-7A
- NF-1
- PPAR-alpha
- STAT5A
- Tal-1beta
Genomic Locations for KRT73 Gene
Genomic Locations for KRT73 Gene
- chr12:52,602,883-52,620,116
- (GRCh38/hg38)
- Size:
- 17,234 bases
- Orientation:
- Minus strand
- chr12:53,001,354-53,012,343
- (GRCh37/hg19)
- Size:
- 10,990 bases
- Orientation:
- Minus strand
Genomic View for KRT73 Gene
Genes around KRT73 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.13 by HGNC
- 12q13.13 by Entrez Gene
- 12q13.13 by Ensembl
KRT73 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KRT73 Gene
Proteins for KRT73 Gene
-
Protein details for KRT73 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86Y46-K2C73_HUMAN
- Recommended name:
- Keratin, type II cytoskeletal 73
- Protein Accession:
- Q86Y46
- Q32MB2
Protein attributes for KRT73 Gene
- Size:
- 540 amino acids
- Molecular mass:
- 58923 Da
- Quaternary structure:
-
- Heterotetramer of two type I and two type II keratins.
- Miscellaneous:
-
- There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).
Protein Expression for KRT73 Gene
Post-translational modifications for KRT73 Gene
Other Protein References for KRT73 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for KRT73
- Invitrogen Antibodies for KRT73 (AFLGC-KRT73)
-
Boster Bio Antibodies for KRT73
Protein Products
-
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No data available for DME Specific Peptides for KRT73 Gene
Domains & Families for KRT73 Gene
Gene Families for KRT73 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for KRT73 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for KRT73 Gene
- GenScript: Design optimal peptide antigens:
-
- Type-II keratin Kb36 (K2C73_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q86Y46- Family:
-
- Belongs to the intermediate filament family.
Function for KRT73 Gene
Molecular function for KRT73 Gene
- UniProtKB/Swiss-Prot Function:
- Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0005198 | structural molecule activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for KRT73 Gene
- GenomeRNAi human phenotypes for KRT73:
-
- Increased HPV18 LCR reporter activity
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability
- no effect
- Decreased viability after sindbis virus (SIN) dsTE12Q infection
- Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization
- Decreased mitophagy mCherry-Parkin protein expression after carbonyl cyanide m-chlorphenylhydrazone (CCCP) stimulation
- Increased vaccinia virus (VACV) infection
- Increased viability
Animal Model Products
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-
CRISPR Products
-
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- RG216365
- RR201476
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Cell Line Products
-
Horizon Cell Lines for KRT73
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT73 Gene
Localization for KRT73 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| mitochondrion | 3 |
| cytoskeleton | 2 |
| peroxisome | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | HDA | 21630459 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005882 | intermediate filament | IEA | -- |
| GO:0045095 | keratin filament | IEA | -- |
| GO:0070062 | extracellular exosome | HDA | 19199708 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRT73 Gene
Pathways & Interactions for KRT73 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Developmental Biology | ||
| 2 | Keratinization |
.33
|
|
Pathways by source for KRT73 Gene
2 Reactome pathways for KRT73 Gene
Interacting Proteins for KRT73 Gene
Selected Interacting proteins:
Q86Y46-K2C73_HUMAN
ENSP00000307014
for KRT73 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for KRT73
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008150 | biological_process | ND | -- |
| GO:0031424 | keratinization | TAS | -- |
| GO:0070268 | cornification | TAS | -- |
No data available for SIGNOR curated interactions for KRT73 Gene
Transcripts for KRT73 Gene
mRNA/cDNA for KRT73 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (2) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000305748 2284 bps (uc001sas.3)
- ENST00000546934 2476 bps (uc058oif.1)
- ENST00000552855 917 bps (uc058oig.1)
CRISPR Products
-
OriGene CRISPR knockouts for KRT73
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KRT73
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- * KRT73 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
Santa Cruz Biotechnology (SCBT) CRISPR for KRT73
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for KRT73
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT73
- genomics-online: shRNA clones - Search results for 82 available KRT73 gene related products
- Overview of 82 available KRT73 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for KRT73 - Now 50% OFF >
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-
- MG208624
- MR208624
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- RR201476
- RR201476L1
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- RR201476L2V
- RR201476L3
- RR201476L3V
- RR201476L4
- RR201476L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Expression for KRT73 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Hair (Integumentary System)
- Fetal Inner Root Sheath Cells Inner Root Sheath
-
Epithelial Cells
- Fetal Inner Root Sheath Cells Inner Root Sheath
-
Heart (Cardiovascular System)
mRNA differential expression in normal tissues according to GTEx for KRT73 Gene
This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x23.0), Skin - Not Sun Exposed (Suprapubic) (x21.8), and Whole Blood (x4.3).
This gene is overexpressed in Saliva (60.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT73 Gene
NURSA nuclear receptor signaling pathways regulating expression of KRT73 Gene:
KRT73SOURCE GeneReport for Unigene cluster for KRT73 Gene:
Hs.55410mRNA Expression by UniProt/SwissProt for KRT73 Gene:
Q86Y46-K2C73_HUMAN
Tissue specificity:
Highly expressed in hair follicles from scalp. In hair, it is specifically present in the inner root sheath (IRS) of the hair follicle. Present in the IRS cuticle, but not in Henle or Huxley layers of the IRS. In the IRS cuticle, it is expressed between the lowermost bulb region of the cuticle and the region where Henle cells undergo abrupt terminal differentiation. Detected up to the uppermost cortex region where cuticle cells terminally differentiate (at protein level).
Evidence on tissue expression from TISSUES for KRT73 Gene
- Skin(4.3)
Primer Products
-
OriGene qPCR primer pairs for KRT73
-
OriGene qPCR primer pairs and template standards for KRT73
- genomics-online: primer clones - Search results for 82 available KRT73 gene related products
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Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT73 Gene
Orthologs for KRT73 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KRT73 35 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | KRT73 34 |
|
||
| cow (Bos Taurus) |
Mammalia | KRT73 35 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Krt73 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Krt73 17 35 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany |
- Species where no ortholog for KRT73 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for KRT73 Gene
- ENSEMBL:
- Gene Tree for KRT73 (if available)
- TreeFam:
- Gene Tree for KRT73 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KRT73: view image
Paralogs for KRT73 Gene
(43) SIMAP similar genes for KRT73 Gene using alignment to 2 proteins:
- K2C73_HUMAN
- H0YIC5_HUMAN
No data available for Paralogs for KRT73 Gene
Variants for KRT73 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1210935768 | A colorectal cancer sample | 52,616,193(-) | C/T | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs142246988 | A colorectal cancer sample | 52,614,655(-) | G/A/C | coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant | |
| rs1000072587 | -- | 52,620,816(-) | T/C | upstream_transcript_variant | |
| rs1000655764 | -- | 52,605,854(-) | G/T | 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant | |
| rs1000875914 | -- | 52,610,198(-) | C/T | intron_variant |
Residual Variation Intolerance Score:
92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.11;
75.50% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KRT73 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- KRT73
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT73 Gene
Disorders for KRT73 Gene
Additional Disease Information for KRT73
No disorders were found for KRT73 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT73 Gene
Publications for KRT73 Gene
- K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle. (PMID: 12648212) Langbein L … Schweizer J (The Journal of investigative dermatology 2003) 2 3 4 23 58
- New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J … Wright MW (The Journal of cell biology 2006) 2 3 58
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
- In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S … Drake RR (Proteomics 2013) 3 58
Products for KRT73 Gene
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Sources for KRT73 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
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