Qing Kenneth Wang,  PhD, MBA

Qing Kenneth Wang, PhD, MBA

Staff and Professor

Lerner Research Institute, 9500 Euclid Avenue, Cleveland, Ohio 44195
Location: NB5-85
Email: wangq2@ccf.org
Phone: (216) 445-0570
Fax: (216) 445-8204

 


Dr. Wang has made distinguished contributions to the field of genetics of cardiovascular and neurological diseases by identifying eight genes for single gene disorders and more than ten susceptibility genes for common complex diseases, and by identifying novel molecular mechanisms underlying channelopathies and other diseases. He was noted for reporting the discoveries of the first Brugada syndrome gene (SCN5A), the most common gene for long QT syndrome (LQTS) (KCNQ1), one of the first two genes reported for LQTS in the same issue of Cell (SCN5A), LQTS gene KCNE1, the first gene for autosomal recessive atrial fibrillation (NUP155), atrial fibrillation gene SCN3B, the first gene for vascular disease Klippel-Trenaunay syndrome (AGGF1), and the first gene for co-existent paroxysmal dyskinesia and generalized epilepsy (KCNMA1). Dr. Wang was the first to show that mutations in ion channels cause arrhythmias and sudden death, and also the first to link a nucleoporin defect to cardiovascular disease. He was also the first to show that autophagy is required for angiogenesis in mice in vivo. Dr. Wang’s early discoveries on cardiac arrhythmias genes have been translated into the first commercial genetic testing kit in the field of cardiovascular medicine (Familion Test), which realized the first successful case of personalized genomic medicine in cardiovascular medicine and saved many human lives. Dr. Wang’s more recent focus on translation research shows that angiogenic factor AGGF1 protein therapy can successfully restore abnormal cardiac function associated with CAD/MI, ischemia-reperfusion, and cardiac hypertrophy/heart failure. Dr. Wang has identified a protein MOG1 that promotes trafficking of cardiac sodium channels to cell membranes, and may serve as a therapy for sodium channelopathies with a trafficking defect.

In other words ...

Qing Wang is currently Staff at Department of Molecular Cardiology, Department of Cardiovascular Medicine, and Neurological Institute, and the Director of Center for Cardiovascular Genetics at the Cleveland Clinic. He is Professor of Molecular Medicine and Professor of Genetics at Case Western Reserve University.  He received B.S. from China in 1984, Ph.D. in Genetics and Developmental Biology from Cornell University in 1993, and M.B.A. from Cleveland State University in 2002.  His postdoctoral research training was with Dr. Mark Keating at the Howard Hughes Medical Institute, University of Utah Health Sciences Center.  Dr. Wang joined the faculty at Baylor College of Medicine as an Assistant Professor (tenure track) in 1996 and Cleveland Clinic as Assistant Staff in 1999.  Dr. Wang has published more than 190 scientific papers and book chapters, and edited two volumes of Methods in Molecular Medicine.  He is an elected Fellow of the American Association for the Advancement of Science.  His research mostly focuses on finding genes for cardiovascular diseases, in particular, cardiac arrhythmias, syncope, seizures, and sudden death.  He also uses a variety of technologies to identify novel molecular mechanisms and develop therapies for diseases.


PUBLICATIONS

  1. Yao Y, Li H, Da X, He Z, Tang B, Li Y, Hu C, Xu C, Chen Q, Wang QK. (2019) SUMOylation of Vps34 by SUMO1 promotes phenotypic switching of vascular smooth muscle cells by activating autophagy in pulmonary arterial hypertension. Pulm Pharmacol Ther. 2019 Jan 28. pii: S1094-5539(18)30153-6. doi: 10.1016/j.pupt.2019.01.007. [Epub ahead of print]
  2. Cho H, Shen GQ, Wang X, Wang F, Archacki S, Li Y, Yu G, Chakrabarti S, Chen Q, Wang QK. (2019) Long noncoding RNA ANRIL regulates endothelial cell activities associated with coronary artery disease by up-regulating CLIP1, EZR, and LYVE1 genes. J Biol Chem. 2019 Jan 17. pii: jbc.RA118.005050. doi: 10.1074/jbc.RA118.005050. [Epub ahead of print]
  3. Tang B, Hu Y, Wang Z, Cheng C, Wang P, Liang L, Xiong H, Luo C, Xu C, Chen Q, Wang QK. (2019) UBC9 regulates cardiac sodium channel Nav1.5 ubiquitination, degradation and sodium current density. J Mol Cell Cardiol. 129:79-91.
  4. Han M, Zhao M, Cheng C, Huang Y, Han S, Li W, Tu X, Luo X, Yu X, Liu Y, Chen Q, Ren X, Wang QK*, Ke T*. (2019) Lamin A mutation impairs interaction with nucleoporin NUP155 and disrupts nucleocytoplasmic transport in atrial fibrillation. Hum Mutat. 40(3):310-325.
  5. Yu S, Jiang T, Jia D, Han Y, Liu F, Huang Y, Qu Z, Zhao Y, Tu J, Lv Y, Li J, Hu X, Lu Z, Han S, Qin Y, Liu X, Xie S, Wang QK, Tang Z, Luo D, Liu M. (2019) BCAS2 is essential for hematopoietic stem and progenitor cell maintenance during zebrafish embryogenesis. Blood. 133(8):805-815.
  6. Yu G, Liu Y, Qin J, Wang Z, Hu Y, Wang F, Li Y, Chakrabarti S, Chen Q*, Wang QK*. (2018) Mechanistic insights into the interaction of the MOG1 protein with the cardiac sodium channel Nav1.5 clarify the molecular basis of Brugada syndrome. J Biol Chem. 293(47):18207-18217.
  7. Hu X, Lu Z, Yu S, Reilly J, Liu F, Jia D, Qin Y, Han S, Liu X, Qu Z, Lv Y, Li J, Huang Y, Jiang T, Jia H, Wang Q, Liu J, Shu X, Tang Z, Liu M. (2018) CERKL regulates autophagy via the NAD-dependent deacetylase SIRT1. Autophagy. 25:1-13.
  8. Zhou Y, Xiao H, Wu J, Zha L, Zhou M, Li Q, Wang M, Shi S, Li Y, Lyu L, Wang Q, Tu X, Lu Q. (2018) Type I Diabetic Akita Mouse Model is Characterized by Abnormal Cardiac Deformation During Early Stages of Diabetic Cardiomyopathy with Speckle-Tracking Based Strain Imaging. Cell Physiol Biochem. 2018;45(4):1541-1550.
  9. Wang Z, Yu G, Liu Y, Liu S, Aridor M, Huang Y, Hu Y, Wang L, Li S, Xiong H, Tang B, Li X, Cheng C, Chakrabarti S, Wang F, Wu Q, Karnik SS, Xu C, Chen Q*, Wang QK*. (2018) Small GTPases SAR1A and SAR1B regulate the trafficking of the cardiac sodium channel Nav1.5. Biochim Biophys Acta Mol Basis Dis. 1864(11):3672-3684.
  10. Wang X, Li J, Yang Z, Wang L, Li L, Deng W, Zhou J, Wang L, Xu C, Chen Q*, Wang QK*. (2018) phlda3 overexpression impairs specification of hemangioblasts and vascular development. FEBS J. 285(21):4071-4081. 
  11. Zhou S, Wang F, Dou Y, Zhou J, Hao G, Xu C, Wang QK, Wang H, Wang P*. (2018) A novel FBN2 mutation cosegregates with congenital contractural arachnodactyly in a five-generation Chinese family. Clin Case Rep. 6(8):1612-1617.
  12. Nie SF, Zha LF, Fan Q, Liao YH, Zhang HS, Chen QW, Wang F, Tang TT, Xia N, Xu CQ, Zhang JY, Lu YZ, Zeng ZP, Jiao J, Li YY, Xie T, Zhang WJ, Wang D, Wang CC, Fa JJ, Xiong HB, Ye J, Yang Q, Wang PY, Tian SH, Lv QL, Li QX, Qian J, Li B, Wu G, Wu YX, Yang Y, Yang XP, Hu Y, Wang QK, Cheng X*, Tu X*. (2018) Genetic Regulation of the Thymic Stromal Lymphopoietin (TSLP)/TSLP Receptor (TSLPR) Gene Expression and Influence of Epistatic Interactions Between IL-33 and the TSLP/TSLPR Axis on Risk of Coronary Artery Disease. Front Immunol. 9:1775.
  13. Wang F, Wang IZ, Ellis S, Archacki S, Barnard J, Hubbard C, Topol EJ, Chen Q*, Wang QK*. (2018) Analysis of causal effect of APOA5 variants on premature coronary artery disease. Ann Hum Genet. 82(6):437-447. 
  14. Zha LF, Nie SF, Chen QW, Liao YH, Zhang HS, Dong JT, Xie T, Wang F, Tang TT, Xia N, Xu CQ, Zhou YC, Zeng ZP, Jiao J, Wang PY, Wang QK, Tu X*, Cheng X*. (2018) IL-13 may be involved in the development of CAD via different mechanisms under different conditions in a Chinese Han population. Sci Rep. 8(1):6182.
  15. Si W, Xie W, Deng W, Xiao Y, Karnik SS, Xu C, Chen Q*, Wang QK*. (2018) Angiotensin II increases angiogenesis by NF-κB-mediated transcriptional activation of angiogenic factor AGGF1. FASEB J. 32(9):5051-5062.
  16. Xiong X, Naji DH, Wang B, Zhao Y, Wang J, Wang D, Zhang Y, Li S, Chen S, Huang Y, Yang Q, Wang X, Yin D, Tu X, Chen Q, Ma X, Xu C*, Wang QK*. (2018) Significant Association between OPG/TNFRSF11B Variant and Common Complex Ischemic Stroke. J Stroke Cerebrovasc Dis. 27(6):1683-1691.
  17. Wang P, Qin W, Wang P, Huang Y, Liu Y, Zhang R, Li S, Yang Q, Wang X, Chen F, Liu J, Yang B, Cheng X, Liao Y, Wu Y, Ke T, Tu X, Ren X, Yang Y, Xia Y, Luo X, Liu M, Li H, Liu J, Xiao Y, Chen Q*, Xu C*, Wang QK*. (2018) Genomic Variants in NEURL, GJA1 and CUX2 Significantly Increase Genetic Susceptibility to Atrial Fibrillation. Sci Rep. 8(1):3297.
  18. Li S, Xi Q, Zhang X, Yu D, Li L, Jiang Z, Chen Q, Wang QK*, Traboulsi EI*.  (2018) Identification of a mutation in CNNM4 by whole exome sequencing in an Amish family and functional link between CNNM4 and IQCB1.  Mol Genet Genomics. 293(3):699-710.
  19. Li X, Poschmann S, Chen Q, Fazeli W, Oundjian NJ, Snoeijen-Schouwenaars FM, Fricke O, Kamsteeg EJ, Willemsen M*, Wang QK*. (2018) De novo BK channel variant causes epilepsy by affecting voltage gating but not Ca2+sensitivity. Eur J Hum Genet. 26(2):220-229.
  20. Naji DH, Tan C, Han F, Zhao Y, Wang J, Wang D, Fa J, Li S, Chen S, Chen Q*, Xu* C, Wang QK*. (2018) Significant genetic association of a functional TFPI variant with circulating fibrinogen levels and coronary artery disease. Mol Genet Genomics 293(1):119-128.
  21. Wang L, Wang X, Wang L, Yousaf M, Li J, Zuo M, Yang Z, Gou D, Bao B, Li L, Xiang N, Jia H, Xu C, Chen Q*, Wang QK*. (2018) Identification of a new adtrp1-tfpi regulatory axis for the specification of primitive myelopoiesis and definitive hematopoiesis. FASEB J. 32(1):183-194.
  22. Wang J, Fa J, Wang P, Jia X, Peng H, Chen J, Wang Y, Wang C, Chen Q, Tu X, Wang QK, Xu C. NINJ2- A novel regulator of endothelial inflammation and activation. Cell signaling. 2017; [Epub ahead of print]. PMID: 28431986
  23. Li J, Zhu X, Yu K, Jiang H, Zhang Y, Deng S, Cheng L, Liu X, Zhong J, Zhang X, He M, Chen W, Yuan J, Gao M, Bai Y, Han X, Liu B, Luo X, Mei W, He X, Sun S, Zhang L, Zeng H, Sun H, Liu C, Guo Y, Zhang B, Zhang Z, Huang J, Pan A, Yuan Y, Angileri F, Ming B, Zheng F, Zeng Q, Mao X, Peng Y, Mao Y, Ye P, Wang QK, Qi L, Hu FB, Liang L, Wu T. Genome-Wide Analysis of DNA Methylation and Acute Coronary Syndrome. Circ Res. 2017; [Epub ahead of print]. PMID: 28348007
  24. Luo C, Wang F, Ren X, Ke T, Xu C, Tang B, Qin S, Yao Y, Chen Q, Wang QK. Identification of a molecular signaling gene-gene regulatory network between GWAS susceptibility genes ADTRP and MIA3/TANGO1 for coronary artery disease. Biochim Biophys Acta. 2017; [Epub ahead of print]. PMID: 28341552
  25. Yin D, Naji DH, Xia Y, Li S, Bai Y, Jiang G, Zhao Y, Wang X, Huang Y, Chen S, Fa J, Tan C, Zhou M, Zhou Y, Wang L, Liu Y, Chen F, Liu J, Chen Q, Tu X, Xu C, Wang QK. Genomic Variant in IL-37 Confers A Significant Risk of Coronary Artery Disease. Scientific reports. 2017; 7:42175. PMCID: PMC5299598
  26. Zhou S, Wang H, Wang QK, Wang P, Wang F, Xu C. Loss of heterozygosity detected at three short tandem repeat locus commonly used for human DNA identification in a case of paternity testing. Legal medicine (Tokyo, Japan). 2017; 24:7-11. PMID: 28081793
  27. Zhang T, Yao Y, Wang J, Li Y, He P, Pasupuleti V, Hu Z, Jia X, Song Q, Tian XL, Hu C, Chen Q, Wang QK. Haploinsufficiency of Klippel-Trenaunay syndrome gene Aggf1 inhibits developmental and pathological angiogenesis by inactivating PI3K and AKT and disrupts vascular integrity by activating VE-cadherin. Human molecular genetics. 2016; 25(23):5094-5110. PMID: 27522498
  28. Ye J, Yao Y, Song Q, Li S, Hu Z, Yu Y, Hu C, Da X, Li H, Chen Q, Wang QK. Up-regulation of miR-95-3p in hepatocellular carcinoma promotes tumorigenesis by targeting p21 expression. Scientific reports. 2016; 6:34034. PMCID: PMC5048429
  29. Luo C, Wang F, Qin S, Chen Q, Wang QK. Coronary artery disease susceptibility gene ADTRP regulates cell cycle progression, proliferation, and apoptosis by global gene expression regulation. Physiological genomics. 2016; 48(8):554-64. PubMed [journal] PMID: 27235449, PMCID: PMC5005456
  30. Lu Q, Yao Y, Hu Z, Hu C, Song Q, Ye J, Xu C, Wang AZ, Chen Q, Wang QK. Angiogenic Factor AGGF1 Activates Autophagy with an Essential Role in Therapeutic Angiogenesis for Heart Disease. PLoS biology. 2016; 14(8):e1002529. PMCID: PMC4981375
  31. Ke T, Han M, Zhao M, Wang QK, Zhang H, Zhao Y, Ruan X, Li H, Xu C, Sun T. Alpha-actin-2 mutations in Chinese patients with a non-syndromatic thoracic aortic aneurysm. BMC medical genetics. 2016; 17(1):45. PMCID: PMC4950238
  32. Huang Y, Wang Z, Liu Y, Xiong H, Zhao Y, Wu L, Yuan C, Wang L, Hou Y, Yu G, Huang Z, Xu C, Chen Q, Wang QK. αB-Crystallin Interacts with Nav1.5 and Regulates Ubiquitination and Internalization of Cell Surface Nav1.5. The Journal of biological chemistry. 2016; 291(21):11030-41. PMCID: PMC4900253
  33. Fan Q, Nie S, Li S, Liao Y, Zhang H, Zha L, Wang F, Tang T, Xia N, Xu C, Wang P, Xie T, Xie J, Lu Q, Li Q, Qian J, Li B, Wu G, Wu Y, Yang Y, Wang QK, Tu X, Cheng X. Analysis of the genetic association between IL27 variants and coronary artery disease in a Chinese Han population. Scientific reports. 2016; 6:25782. PMCID: PMC4865940
  34. Zhang KK, Xiang M, Zhou L, Liu J, Curry N, Heine Suñer D, Garcia-Pavia P, Zhang X, Wang Q, Xie L. Gene network and familial analyses uncover a gene network involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial septation. Human molecular genetics. 2016; 25(6):1140-51. PMCID: PMC4764195
  35. Chen S, Wang X, Wang J, Zhao Y, Wang D, Tan C, Fa J, Zhang R, Wang F, Xu C, Huang Y, Li S, Yin D, Xiong X, Li X, Chen Q, Tu X, Yang Y, Xia Y, Xu C, Wang QK. Genomic variant in CAV1 increases susceptibility to coronary artery disease and myocardial infarction. Atherosclerosis. 2016; 246:148-56. NIHMSID: NIHMS752498 PMCID: PMC4764411
  36. Zhou J, Wang L, Zuo M, Wang X, Ahmed AS, Chen Q, Wang QK. Cardiac sodium channel regulator MOG1 regulates cardiac morphogenesis and rhythm. Scientific reports. 2016; 6:21538. PMCID: PMC4763225
  37. Wang C, Wu M, Qian J, Li B, Tu X, Xu C, Li S, Chen S, Zhao Y, Huang Y, Shi L, Cheng X, Liao Y, Chen Q, Xia Y, Yao W, Wu G, Cheng M, Wang QK. Identification of rare variants in TNNI3 with atrial fibrillation in a Chinese GeneID population. Molecular genetics and genomics : MGG. 2016; 291(1):79-92. NIHMSID: NIHMS707859 PMCID: PMC4713376
  38. Zhao Y, Sun Q, Zeng Z, Li Q, Zhou S, Zhou M, Xue Y, Cheng X, Xia Y, Wang Q, Tu X. Regulation of SCN3B/scn3b by Interleukin 2 (IL-2): IL-2 modulates SCN3B/scn3b transcript expression and increases sodium current in myocardial cells. BMC cardiovascular disorders. 2016; 16:1. PMCID: PMC4700781
  39. Zhao Y, Liu M, Wang X, Chen S, Zhou M, Li Q, Li S, Huang Y, Zhao L, Wang Q, Tu X. Elevated serum chloride is an independent risk factor for coronary heart disease: A retrospective study of more than 13,000 Han Chinese. International journal of cardiology. 2015; 198:61-2. PMID: 26151716
  40. Zhao Y, Huang Y, Li W, Wang Z, Zhan S, Zhou M, Yao Y, Zeng Z, Hou Y, Chen Q, Tu X, Wang QK, Huang Z. Post-transcriptional regulation of cardiac sodium channel gene SCN5A expression and function by miR-192-5p. Biochimica et biophysica acta. 2015; 1852(10 Pt A):2024-34. NIHMSID: NIHMS758814 PMCID: PMC4757900
  41. Huang Y, Wang C, Yao Y, Zuo X, Chen S, Xu C, Zhang H, Lu Q, Chang L, Wang F, Wang P, Zhang R, Hu Z, Song Q, Yang X, Li C, Li S, Zhao Y, Yang Q, Yin D, Wang X, Si W, Li X, Xiong X, Wang D, Huang Y, Luo C, Li J, Wang J, Chen J, Wang L, Wang L, Han M, Ye J, Chen F, Liu J, Liu Y, Wu G, Yang B, Cheng X, Liao Y, Wu Y, Ke T, Chen Q, Tu X, Elston R, Rao S, Yang Y, Xia Y, Wang QK. Molecular Basis of Gene-Gene Interaction: Cyclic Cross-Regulation of Gene Expression and Post-GWAS Gene-Gene Interaction Involved in Atrial Fibrillation. PLoS genetics. 2015; 11(8):e1005393. PMCID: PMC4534423
  42. Liu H, Liu W, Lin Y, Liu T, Ma Z, Li M, Zhang HM, Kenneth Wang Q, Guo AY. Scoring the correlation of genes by their shared properties using OScal, an improved overlap quantification model. Scientific reports. 2015; 5:10583. PMCID: PMC4445036
  43. Chen S, Wang C, Wang X, Xu C, Wu M, Wang P, Tu X, Wang QK. Significant Association Between CAV1 Variant rs3807989 on 7p31 and Atrial Fibrillation in a Chinese Han Population. Journal of the American Heart Association. 2015; 4(5). PMCID: PMC4599427
  44. Xia N, Jiao J, Tang TT, Lv BJ, Lu YZ, Wang KJ, Zhu ZF, Mao XB, Nie SF, Wang Q, Tu X, Xiao H, Liao YH, Shi GP, Cheng X. Activated regulatory T-cells attenuate myocardial ischaemia/reperfusion injury through a CD39-dependent mechanism. Clinical science (London, England : 1979). 2015; 128(10):679-93. PMID: 25558978
  45. He M, Xu M, Zhang B, Liang J, Chen P, Lee JY, Johnson TA, Li H, Yang X, Dai J, Liang L, Gui L, Qi Q, Huang J, Li Y, Adair LS, Aung T, Cai Q, Cheng CY, Cho MC, Cho YS, Chu M, Cui B, Gao YT, Go MJ, Gu D, Gu W, Guo H, Hao Y, Hong J, Hu Z, Hu Y, Huang J, Hwang JY, Ikram MK, Jin G, Kang DH, Khor CC, Kim BJ, Kim HT, Kubo M, Lee J, Lee J, Lee NR, Li R, Li J, Liu J, Longe J, Lu W, Lu X, Miao X, Okada Y, Ong RT, Qiu G, Seielstad M, Sim X, Song H, Takeuchi F, Tanaka T, Taylor PR, Wang L, Wang W, Wang Y, Wu C, Wu Y, Xiang YB, Yamamoto K, Yang H, Liao M, Yokota M, Young T, Zhang X, Kato N, Wang QK, Zheng W, Hu FB, Lin D, Shen H, Teo YY, Mo Z, Wong TY, Lin X, Mohlke KL, Ning G, Tsunoda T, Han BG, Shu XO, Tai ES, Wu T, Qi L. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. Human molecular genetics. 2015; 24(6):1791-800. PMCID: PMC4351379
  46. Zhang X, Bogunovic D, Payelle-Brogard B, Francois-Newton V, Speer SD, Yuan C, Volpi S, Li Z, Sanal O, Mansouri D, Tezcan I, Rice GI, Chen C, Mansouri N, Mahdaviani SA, Itan Y, Boisson B, Okada S, Zeng L, Wang X, Jiang H, Liu W, Han T, Liu D, Ma T, Wang B, Liu M, Liu JY, Wang QK, Yalnizoglu D, Radoshevich L, Uzé G, Gros P, Rozenberg F, Zhang SY, Jouanguy E, Bustamante J, García-Sastre A, Abel L, Lebon P, Notarangelo LD, Crow YJ, Boisson-Dupuis S, Casanova JL, Pellegrini S. Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation. Nature. 2015; 517(7532):89-93. NIHMSID: NIHMS653880 PMCID: PMC4303590
  47. Wang P, Xu C, Wang C, Wu Y, Wang D, Chen S, Zhao Y, Wang X, Li S, Yang Q, Zeng Q, Tu X, Liao Y, Wang QK, Cheng X. Association of SNP Rs9943582 in APLNR with Left Ventricle Systolic Dysfunction in Patients with Coronary Artery Disease in a Chinese Han GeneID Population. PloS one. 2015; 10(5):e0125926. PMCID: PMC4438007
  48. Chen FF, Xia YL, Xu CQ, Li SS, Zhao YY, Wang XJ, Chen SS, Gao LJ, Zhong Y, Tu X, Wang Q, Yang YZ. Common variant rs7597774 in ADD2 is associated with dilated cardiomyopathy in Chinese Han population. International journal of clinical and experimental medicine. 2015; 8(1):1188-96. PMCID: PMC4358567
  49. Xu C, Yang Q, Xiong H, Wang L, Cai J, Wang F, Li S, Chen J, Wang C, Wang D, Xiong X, Wang P, Zhao Y, Wang X, Huang Y, Chen S, Yin D, Li X, Liu Y, Liu J, Wang J, Li H, Ke T, Ren X, Wu Y, Wu G, Wan J, Zhang R, Wu T, Wang J, Xia Y, Yang Y, Cheng X, Liao Y, Chen Q, Zhou Y, He Q, Tu X, Wang QK. Candidate pathway-based genome-wide association studies identify novel associations of genomic variants in the complement system associated with coronary artery disease. Circulation. Cardiovascular genetics. 2014; 7(6):887-94. NIHMSID: NIHMS633495 PMCID: PMC4270888
  50. Zhou SF, Yuan J, Liao MY, Xia N, Tang TT, Li JJ, Jiao J, Dong WY, Nie SF, Zhu ZF, Zhang WC, Lv BJ, Xiao H, Wang Q, Tu X, Liao YH, Shi GP, Cheng X. IL-17A promotes ventricular remodeling after myocardial infarction. Journal of molecular medicine (Berlin, Germany). 2014; 92(10):1105-16. PMID: 24965614
  51. Shen GQ, Girelli D, Li L, Rao S, Archacki S, Olivieri O, Martinelli N, Park JE, Chen Q, Topol EJ, Wang QK. A novel molecular diagnostic marker for familial and early-onset coronary artery disease and myocardial infarction in the LRP8 gene. Circulation. Cardiovascular genetics. 2014; 7(4):514-20. NIHMSID: NIHMS600241 PMCID: PMC4140990
  52. Xu Y, Zhou M, Wang J, Zhao Y, Li S, Zhou B, Su Z, Xu C, Xia Y, Qian H, Tu X, Xiao W, Chen X, Chen Q, Wang QK. Role of microRNA-27a in down-regulation of angiogenic factor AGGF1 under hypoxia associated with high-grade bladder urothelial carcinoma. Biochimica et biophysica acta. 2014; 1842(5):712-25. PMID: 24462738
  53. Xiong X, Xu C, Zhang Y, Li X, Wang B, Wang F, Yang Q, Wang D, Wang X, Li S, Chen S, Zhao Y, Yin D, Huang Y, Zhu X, Wang L, Wang L, Chang L, Xu C, Li H, Ke T, Ren X, Wu Y, Zhang R, Wu T, Xia Y, Yang Y, Ma X, Tu X, Wang QK. BRG1 variant rs1122608 on chromosome 19p13.2 confers protection against stroke and regulates expression of pre-mRNA-splicing factor SFRS3. Human genetics. 2014;133(5):499-508. NIHMSID: NIHMS560974 PMCID: PMC3988217
  54. Su Z, Si W, Li L, Zhou B, Li X, Xu Y, Xu C, Jia H, Wang QK. MiR-144 regulates hematopoiesis and vascular development by targeting meis1 during zebrafish development. The international journal of biochemistry & cell biology. 2014; 49:53-63. PMID: 24448023
  55. Bai Y, Nie S, Jiang G, Zhou Y, Zhou M, Zhao Y, Li S, Wang F, Lv Q, Huang Y, Yang Q, Li Q, Li Y, Xia Y, Liu Y, Liu J, Qian J, Li B, Wu G, Wu Y, Wang B, Cheng X, Yang Y, Ke T, Li H, Ren X, Ma X, Liao Y, Xu C, Tu X, Wang QK. Regulation of CARD8 expression by ANRIL and association of CARD8 single nucleotide polymorphism rs2043211 (p.C10X) with ischemic stroke. Stroke. 2014; 45(2):383-8. NIHMSID: NIHMS559913 PMCID: PMC39626865.
  56. Li L, Chen D, Li J, Wang X, Wang N, Xu C, Wang QK. Aggf1 acts at the top of the genetic regulatory hierarchy in specification of hemangioblasts in zebrafish. Blood. 2014; 123(4):501-8. PMCID: PMC3901065
  57. Gao H, Li L, Rao S, Shen G, Xi Q, Chen S, Zhang Z, Wang K, Ellis SG, Chen Q, Topol EJ, Wang QK. Genome-wide linkage scan identifies two novel genetic loci for coronary artery disease: in GeneQuest families. PloS one. 2014; 9(12):e113935. PMCID: PMC4259362
  58. Li X, Huang Y, Yin D, Wang D, Xu C, Wang F, Yang Q, Wang X, Li S, Chen S, Xiong X, Huang Y, Zhao Y, Wang L, Zhu X, Su Z, Zhou B, Zhang Y, Wang L, Chang L, Xu C, Li H, Ke T, Ren X, Cheng X, Yang Y, Liao Y, Tu X, Wang QK. Meta-analysis identifies robust association between SNP rs17465637 in MIA3 on chromosome 1q41 and coronary artery disease. Atherosclerosis. 2013; 231(1):136-40. PMID: 24125424
  59. Tu X, Nie S, Liao Y, Zhang H, Fan Q, Xu C, Bai Y, Wang F, Ren X, Tang T, Xia N, Li S, Huang Y, Liu J, Yang Q, Zhao Y, Lv Q, Li Q, Li Y, Xia Y, Qian J, Li B, Wu G, Wu Y, Yang Y, Wang QK, Cheng X. The IL-33-ST2L pathway is associated with coronary artery disease in a Chinese Han population. American journal of human genetics. 2013; 93(4):652-60. PMCID: PMC3791271
  60. Zhang C, Li D, Zhang J, Chen X, Huang M, Archacki S, Tian Y, Ren W, Mei A, Zhang Q, Fang M, Su Z, Yin Y, Liu D, Chen Y, Cui X, Li C, Yang H, Wang Q, Wang J, Liu M, Deng Y. Mutations in ABCB6 cause dyschromatosis universalis hereditaria. The Journal of investigative dermatology. 2013; 133(9):2221-8. PMID: 23519333
  61. Zhou B, Ma R, Si W, Li S, Xu Y, Tu X, Wang Q. MicroRNA-503 targets FGF2 and VEGFA and inhibits tumor angiogenesis and growth. Cancer letters. 2013; 333(2):159-69. PMID: 23352645
  62. Shen GQ, Girelli D, Li L, Olivieri O, Martinelli N, Chen Q, Topol EJ, Wang QK. Multi-allelic haplotype association identifies novel information different from single-SNP analysis: a new protective haplotype in the LRP8 gene is against familial and early-onset CAD and MI. Gene. 2013; 521(1):78-81. NIHMSID: NIHMS537725 PMCID: PMC3919654
  63. Chakrabarti S, Wu X, Yang Z, Wu L, Yong SL, Zhang C, Hu K, Wang QK, Chen Q. MOG1 rescues defective trafficking of Na(v)1.5 mutations in Brugada syndrome and sick sinus syndrome. Circulation. Arrhythmia and electrophysiology. 2013; 6(2):392-401. NIHMSID: NIHMS443434 PMCID: PMC3633223
  64. Zhou B, Si W, Su Z, Deng W, Tu X, Wang Q. Transcriptional activation of the Prox1 gene by HIF-1α and HIF-2α in response to hypoxia. FEBS letters. 2013; 587(6):724-31. PMID: 23395615
  65. Chan K, Patel RS, Newcombe P, Nelson CP, Qasim A, Epstein SE, Burnett S, Vaccarino VL, Zafari AM, Shah SH, Anderson JL, Carlquist JF, Hartiala J, Allayee H, Hinohara K, Lee BS, Erl A, Ellis KL, Goel A, Schaefer AS, El Mokhtari NE, Goldstein BA, Hlatky MA, Go AS, Shen GQ, Gong Y, Pepine C, Laxton RC, Whittaker JC, Tang WH, Johnson JA, Wang QK, Assimes TL, Nöthlings U, Farrall M, Watkins H, Richards AM, Cameron VA, Muendlein A, Drexel H, Koch W, Park JE, Kimura A, Shen WF, Simpson IA, Hazen SL, Horne BD, Hauser ER, Quyyumi AA, Reilly MP, Samani NJ, Ye S. Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis. Journal of the American College of Cardiology. 2013; 61(9):957-70. NIHMSID: NIHMS451694 PMCID: PMC3653306
  66. Chen D, Li L, Tu X, Yin Z, Wang Q. Functional characterization of Klippel-Trenaunay syndrome gene AGGF1 identifies a novel angiogenic signaling pathway for specification of vein differentiation and angiogenesis during embryogenesis. Human molecular genetics. 2013; 22(5):963-76. PMID: 23197652
  67. Wang Q, Liu F, Xing Y, Wei X, Li H, Zhang S, Liu J, Wang Q, Tang Z, Liu M. Mutation c.359_363delGTATTinsATAC in the COL4A5 causes Alport syndrome in a Chinese family. Gene. 2013; 512(2):482-5. PMID: 23085274
  68. Zang X, Zhang S, Xia Y, Li S, Fu F, Li X, Wang F, Zhang R, Tian X, Gao L, Zhang J, Yang Y, Tu X, Wang Q. SNP rs3825214 in TBX5 is associated with lone atrial fibrillation in Chinese Han population. PloS one. 2013; 8(5):e64966. PMCID: PMC3663751
  69. Liu Y, Wang DK, Jiang DZ, Qin X, Xie ZD, Wang QK, Liu M, Chen LM. Cloning and functional characterization of novel variants and tissue-specific expression of alternative amino and carboxyl termini of products of slc4a10. PloS one. 2013; 8(2):e55974. PMCID: PMC3567025
  70. Timur AA, Murugesan G, Zhang L, Aung PP, Barnard J, Wang QK, Gaussem P, Silverstein RL, Bhatt DL, Kottke-Marchant K. P2RY1 and P2RY12 polymorphisms and on-aspirin platelet reactivity in patients with coronary artery disease. International journal of laboratory hematology. 2012; 34(5):473-83. NIHMSID: NIHMS365621 PMCID: PMC3419334
  71. Shen GQ, Li L, Wang QK. Genetic variant R952Q in LRP8 is associated with increased plasma triglyceride levels in patients with early-onset CAD and MI. Annals of human genetics. 2012; 76(3):193-9. PMID: 22404453
  72. Archacki SR, Angheloiu G, Moravec CS, Liu H, Topol EJ, Wang QK. Comparative gene expression analysis between coronary arteries and internal mammary arteries identifies a role for the TES gene in endothelial cell functions relevant to coronary artery disease. Human molecular genetics. 2012; 21(6):1364-73. PMID: 22156939
  73. Wang C, Li Y, Shi L, Ren J, Patti M, Wang T, de Oliveira JR, Sobrido MJ, Quintáns B, Baquero M, Cui X, Zhang XY, Wang L, Xu H, Wang J, Yao J, Dai X, Liu J, Zhang L, Ma H, Gao Y, Ma X, Feng S, Liu M, Wang QK, Forster IC, Zhang X, Liu JY. Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis. Nature genetics. 2012; 44(3):254-6. PMID: 22327515
  74. Lu Q, Yao Y, Yao Y, Liu S, Huang Y, Lu S, Bai Y, Zhou B, Xu Y, Li L, Wang N, Wang L, Zhang J, Cheng X, Qin G, Ma W, Xu C, Tu X, Wang Q. Angiogenic factor AGGF1 promotes therapeutic angiogenesis in a mouse limb ischemia model. PloS one. 2012; 7(10):e46998. PMCID: PMC3479102
  75. Cui X, Zeng F, Liu Y, Zhang J, Archacki S, Zhan T, Du R, Tang Z, Liu J, Wang QK, Liu M. A novel SCN1A missense mutation causes generalized epilepsy with febrile seizures plus in a Chinese family. Neuroscience letters. 2011; 503(1):27-30. PMID: 21843600
  76. Yang Q, Li L, Chen Q, Foldvary-Schaefer N, Ondo WG, Wang QK. Association studies of variants in MEIS1, BTBD9, and MAP2K5/SKOR1 with restless legs syndrome in a US population. Sleep medicine. 2011; 12(8):800-4. NIHMSID: NIHMS320089 PMCID: PMC3514407
  77. Wang AZ, Li L, Zhang B, Shen GQ, Wang QK. Association of SNP rs17465637 on chromosome 1q41 and rs599839 on 1p13.3 with myocardial infarction in an American caucasian population. Annals of human genetics. 2011; 75(4):475-82. NIHMSID: NIHMS275834 PMCID: PMC3115468
  78. Ghosh A, Murugesan G, Chen K, Zhang L, Wang Q, Febbraio M, Anselmo RM, Marchant K, Barnard J, Silverstein RL. Platelet CD36 surface expression levels affect functional responses to oxidized LDL and are associated with inheritance of specific genetic polymorphisms. Blood. 2011; 117(23):6355-66. PMCID: PMC3122954
  79. Ding H, Tu X, Xu Y, Xu C, Wang X, Cui G, Bao X, Hui R, Wang QK, Wang DW. No evidence for association of 12p13 SNPs rs11833579 and rs12425791 within NINJ2 gene with ischemic stroke in Chinese Han population. Atherosclerosis. 2011; 216(2):381-2. PMID: 21376321
  80. Xu Z, Li Y, Zhang X, Zeng F, Yuan M, Liu M, Wang QK, Liu JY. Identification and molecular characterization of two novel mutations in COL1A2 in two Chinese families with osteogenesis imperfecta. Journal of genetics and genomics = Yichuan xue bao. 2011; 38(4):149-56. PMID: 21530898
  81. Wang F, Xu CQ, He Q, Cai JP, Li XC, Wang D, Xiong X, Liao YH, Zeng QT, Yang YZ, Cheng X, Li C, Yang R, Wang CC, Wu G, Lu QL, Bai Y, Huang YF, Yin D, Yang Q, Wang XJ, Dai DP, Zhang RF, Wan J, Ren JH, Li SS, Zhao YY, Fu FF, Huang Y, Li QX, Shi SW, Lin N, Pan ZW, Li Y, Yu B, Wu YX, Ke YH, Lei J, Wang N, Luo CY, Ji LY, Gao LJ, Li L, Liu H, Huang EW, Cui J, Jia N, Ren X, Li H, Ke T, Zhang XQ, Liu JY, Liu MG, Xia H, Yang B, Shi LS, Xia YL, Tu X, Wang QK. Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population. Nature genetics. 2011; 43(4):345-9. PMID: 21378986
  82. Zhang T, Yong SL, Drinko JK, Popović ZB, Shryock JC, Belardinelli L, Wang QK. LQTS mutation N1325S in cardiac sodium channel gene SCN5A causes cardiomyocyte apoptosis, cardiac fibrosis and contractile dysfunction in mice. International journal of cardiology. 2011; 147(2):239-45. NIHMSID: NIHMS144047 PMCID: PMC2891203
  83. Li C, Wang F, Yang Y, Fu F, Xu C, Shi L, Li S, Xia Y, Wu G, Cheng X, Liu H, Wang C, Wang P, Hao J, Ke Y, Zhao Y, Liu M, Zhang R, Gao L, Yu B, Zeng Q, Liao Y, Yang B, Tu X, Wang QK. Significant association of SNP rs2106261 in the ZFHX3 gene with atrial fibrillation in a Chinese Han GeneID population. Human genetics. 2011; 129(3):239-46. NIHMSID: NIHMS820129 PMCID: PMC5069458
  84. Yang Q, Li L, Yang R, Shen GQ, Chen Q, Foldvary-Schaefer N, Ondo WG, Wang QK. Family-based and population-based association studies validate PTPRD as a risk factor for restless legs syndrome. Movement disorders : official journal of the Movement Disorder Society. 2011; 26(3):516-9. NIHMSID: NIHMS537722 PMCID: PMC3895410
  85. Cheng X, Shi L, Nie S, Wang F, Li X, Xu C, Wang P, Yang B, Li Q, Pan Z, Li Y, Xia H, Zheng C, Ke Y, Wu Y, Tang T, Yan X, Yang Y, Xia N, Yao R, Wang B, Ma X, Zeng Q, Tu X, Liao Y, Wang QK. The same chromosome 9p21.3 locus is associated with type 2 diabetes and coronary artery disease in a Chinese Han population. Diabetes. 2011; 60(2):680-4. PMCID: PMC3028370
  86. Ouyang P, Saarel E, Bai Y, Luo C, Lv Q, Xu Y, Wang F, Fan C, Younoszai A, Chen Q, Tu X, Wang QK. A de novo mutation in NKX2.5 associated with atrial septal defects, ventricular noncompaction, syncope and sudden death. Clinica chimica acta; international journal of clinical chemistry. 2011; 412(1-2):170-5. NIHMSID: NIHMS247841 PMCID: PMC2998397
  87. Liu H, Liu W, Liao Y, Cheng L, Liu Q, Ren X, Shi L, Tu X, Wang QK, Guo AY. CADgene: a comprehensive database for coronary artery disease genes. Nucleic acids research. 2011; 39(Database issue):D991-6. PMCID: PMC3013698
  88. Gao Y, Yang K, Xu S, Wang C, Liu J, Zhang Z, Yuan M, Luo X, Liu M, Wang QK, Liu JY. Identification of compound heterozygous mutations in GNPTG in three siblings of a Chinese family with mucolipidosis type III gamma. Molecular genetics and metabolism. 2011; 102(1):107-9. PMID: 20951619
  89. Zhou L, Ding H, Zhang X, He M, Huang S, Xu Y, Shi Y, Cui G, Cheng L, Wang QK, Hu FB, Wang D, Wu T. Genetic variants at newly identified lipid loci are associated with coronary heart disease in a Chinese Han population. PloS one. 2011; 6(11):e27481. PMCID: PMC3215720
  90. Wang C, Cao D, Wang Q, Wang DZ. Synergistic activation of cardiac genes by myocardin and Tbx5. PloS one. 2011; 6(8):e24242. PMCID: PMC3163680
  91. Dai X, Gao Y, Xu Z, Cui X, Liu J, Li Y, Xu H, Liu M, Wang QK, Liu JY. Identification of a novel genetic locus on chromosome 8p21.1-q11.23 for idiopathic basal ganglia calcification. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2010; 153B(7):1305-10. PMID: 20552677
  92. Huang Y, Zhang J, Li C, Yang G, Liu M, Wang QK, Tang Z. Identification of a novel homozygous nonsense mutation in EYS in a Chinese family with autosomal recessive retinitis pigmentosa. BMC medical genetics. 2010; 11:121. PMCID: PMC2927534
  93. Xu C, Wang F, Wang B, Li X, Li C, Wang D, Xiong X, Wang P, Lu Q, Wang X, Yang Q, Yin D, Huang Y, Ji L, Wang N, Chen S, Cheng X, Liao Y, Ma X, Su D, Chen G, Xia H, Shi L, Tu X, Wang QK. Minor allele C of chromosome 1p32 single nucleotide polymorphism rs11206510 confers risk of ischemic stroke in the Chinese Han population. Stroke. 2010; 41(8):1587-92. PubMed [journal] PMID: 20576952
  94. Yin W, Ye X, Shi L, Wang QK, Jin H, Wang P, Bian Z. TP63 gene mutations in Chinese P63 syndrome patients. Journal of dental research. 2010; 89(8):813-7. PMID: 20410354
  95. Wang P, Yang Q, Wu X, Yang Y, Shi L, Wang C, Wu G, Xia Y, Yang B, Zhang R, Xu C, Cheng X, Li S, Zhao Y, Fu F, Liao Y, Fang F, Chen Q, Tu X, Wang QK. Functional dominant-negative mutation of sodium channel subunit gene SCN3B associated with atrial fibrillation in a Chinese GeneID population. Biochemical and biophysical research communications. 2010; 398(1):98-104. NIHMSID: NIHMS215253 PMCID: PMC3132081
  96. Yang R, Li L, Seidelmann SB, Shen GQ, Sharma S, Rao S, Abdullah KG, Mackinlay KG, Elston RC, Chen Q, Topol EJ, Wang QK. A genome-wide linkage scan identifies multiple  quantitative trait loci for HDL-cholesterol levels in families with premature CAD and MI. Journal of lipid research. 2010; 51(6):1442-51. PMCID: PMC3035507
  97. Ren X, Xu C, Zhan C, Yang Y, Shi L, Wang F, Wang C, Xia Y, Yang B, Wu G, Wang P, Li X, Wang D, Xiong X, Liu J, Liu Y, Liu M, Liu J, Tu X, Wang QK. Identification of NPPA variants associated with atrial fibrillation in a Chinese GeneID population. Clinica chimica acta; international journal of clinical chemistry. 2010; 411(7-8):481-5. PMID: 20064500
  98. Wang Q, Diao Y, Xu Z, Li X, Luo XP, Xu H, Ouyang P, Liu M, Hu Z, Wang QK, Liu JY. Identification of a novel splicing mutation in the growth hormone (GH)-releasing hormone receptor gene in a Chinese family with pituitary dwarfism. Molecular and cellular endocrinology. 2009; 313(1-2):50-6. PMID: 19733620
  99. Shi L, Li C, Wang C, Xia Y, Wu G, Wang F, Xu C, Wang P, Li X, Wang D, Xiong X, Bai Y, Liu M, Liu J, Ren X, Gao L, Wang B, Zeng Q, Yang B, Ma X, Yang Y, Tu X, Wang QK. Assessment of association of rs2200733 on chromosome 4q25 with atrial fibrillation and ischemic stroke in a Chinese Han population. Human genetics. 2009; 126(6):843-9. PMID: 19707791
  100. Ke T, Gomez CR, Mateus HE, Castano JA, Wang QK. Novel CACNA1S mutation causes autosomal dominant hypokalemic periodic paralysis in a South American family. Journal of human genetics. 2009; 54(11):660-4. PMID: 19779499
  101. Li H, Zhan T, Li C, Liu M, Wang QK. Repression of MHC class I transcription by HPV16E7 through interaction with a putative RXRbeta motif and NF-kappaB cytoplasmic sequestration. Biochemical and biophysical research communications. 2009; 388(2):383-8. PMID: 19665994
  102. Fan C, Chen Q, Wang QK. Functional role of transcriptional factor TBX5 in pre-mRNA splicing and Holt-Oram syndrome via association with SC35. The Journal of biological chemistry. 2009; 284(38):25653-63. PMCID: PMC2757967
  103. Chen Q, Zhang T, Roshetsky JF, Ouyang Z, Essers J, Fan C, Wang Q, Hinek A, Plow EF, Dicorleto PE. Fibulin-4 regulates expression of the tropoelastin gene and consequent elastic-fibre formation by human fibroblasts. The Biochemical journal. 2009; 423(1):79-89. NIHMSID: NIHMS261918 PMCID: PMC3024593
  104. Fan C, Ouyang P, Timur AA, He P, You SA, Hu Y, Ke T, Driscoll DJ, Chen Q, Wang QK. Novel roles of GATA1 in regulation of angiogenic factor AGGF1 and endothelial cell function. The Journal of biological chemistry. 2009; 284(35):23331-43. PMCID: PMC2749107
  105. Ye X, Shi L, Yin W, Meng L, Wang QK, Bian Z. Further evidence of genetic heterogeneity segregating with hereditary gingival fibromatosis. Journal of clinical periodontology. 2009; 36(8):627-33. PMID: 19552635
  106. Tang Z, Wang Z, Wang Z, Ke T, Wang QK, Liu M. Novel compound heterozygous mutations in CERKL cause autosomal recessive retinitis pigmentosa in a nonconsanguineous Chinese family. Archives of ophthalmology (Chicago, Ill. : 1960). 2009; 127(8):1077-8. PMID: 19667359
  107. Martinelli N, Olivieri O, Shen GQ, Trabetti E, Pizzolo F, Busti F, Friso S, Bassi A, Li L, Hu Y, Pignatti PF, Corrocher R, Wang QK, Girelli D. Additive effect of LRP8/APOER2 R952Q variant to APOE epsilon2/epsilon3/epsilon4 genotype in modulating apolipoprotein E concentration and the risk of myocardial infarction: a case-control study. BMC medical genetics. 2009; 10:41. PMCID: PMC2689206
  108. Xi Q, Li L, Traboulsi EI, Wang QK. Novel ABCA4 compound heterozygous mutations cause severe progressive autosomal recessive cone-rod dystrophy presenting as Stargardt disease. Molecular vision. 2009; 15:638-45. PMCID: PMC2665199
  109. Liu JZ, Yang T, Li X, Liu M, Wang QK, Liu JY. A novel mutation in the ATP2C1 gene is associated with Hailey-Hailey disease in a Chinese family. International journal of dermatology. 2009; 48(1):47-51. PMID: 19126050
  110. Zhang X, Chen S, Yoo S, Chakrabarti S, Zhang T, Ke T, Oberti C, Yong SL, Fang F, Li L, de la Fuente R, Wang L, Chen Q, Wang QK. Mutation in nuclear pore component NUP155 leads to atrial fibrillation and early sudden cardiac death. Cell. 2008; 135(6):1017-27. PMID: 19070573
  111. Dai XH, Chen WW, Wang X, Zhu QH, Li C, Li L, Liu MG, Wang QK, Liu JY. A novel genetic locus for familial febrile seizures and epilepsy on chromosome 3q26.2-q26.33. Human genetics. 2008; 124(4):423-9. PMID: 18830713
  112. Zhang X, Chen S, Zhang L, Liu M, Redfearn S, Bryant RM, Oberti C, Vincent GM, Wang QK. Protective effect of KCNH2 single nucleotide polymorphism K897T in LQTS families and identification of novel KCNQ1 and KCNH2 mutations. BMC medical genetics. 2008; 9:87. PMCID: PMC2570672
  113. Abdullah KG, Li L, Shen GQ, Hu Y, Yang Y, MacKinlay KG, Topol EJ, Wang QK. Four SNPS on chromosome 9p21 confer risk to premature, familial CAD and MI in an American Caucasian population (GeneQuest). Annals of human genetics. 2008; 72(Pt 5):654-7. NIHMSID: NIHMS81968 PMCID: PMC2634771
  114. Hu Y, Li L, Seidelmann SB, Timur AA, Shen PH, Driscoll DJ, Wang QK. Identification of association of common AGGF1 variants with susceptibility for Klippel-Trenaunay syndrome using the structure association program. Annals of human genetics. 2008; 72(Pt 5):636-43. NIHMSID: NIHMS81970 PMCID: PMC2602961
  115. Liu P, Li H, Ren X, Mao H, Zhu Q, Zhu Z, Yang R, Yuan W, Liu J, Wang Q, Liu M. Novel ACTG1 mutation causing autosomal dominant non-syndromic hearing impairment in a Chinese family. Journal of genetics and genomics = Yi chuan xue bao. 2008; 35(9):553-8. PMID: 18804074
  116. Liu P, Zhang S, Yao Q, Liu X, Wang X, Huang C, Huang X, Wang P, Yuan M, Liu JY, Wang QK, Liu M. Identification of a genetic locus for autosomal dominant disseminated superficial actinic porokeratosis on chromosome 1p31.3-p31.1. Human genetics. 2008; 123(5):507-13. PMID: 18443824
  117. Zhang S, Wang L, Hao Y, Wang P, Hao P, Yin K, Wang QK, Liu M. T14484C and T14502C in the mitochondrial ND6 gene are associated with Leber's hereditary optic neuropathy in a Chinese family. Mitochondrion. 2008; 8(3):205-10. PMID: 18440284
  118. Liu P, Yang Q, Wang X, Feng A, Yang T, Yang R, Wang P, Yuang M, Liu M, Liu JY, Wang QK. Identification of a genetic locus for ichthyosis vulgaris on chromosome 10q22.3-q24.2. The Journal of investigative dermatology. 2008; 128(6):1418-22. PMID: 18079749
  119. Li H, Li C, Lu Q, Su T, Ke T, Li DW, Yuan M, Liu J, Ren X, Zhang Z, Zeng S, Wang QK, Liu M. Cataract mutation P20S of alphaB-crystallin impairs chaperone activity of alphaA-crystallin and induces apoptosis of human lens epithelial cells. Biochimica et biophysica acta. 2008; 1782(5):303-9. PMID: 18343237
  120. Seidelmann SB, Li L, Shen GQ, Topol EJ, Wang QK. Identification of a novel locus for triglyceride on chromosome 1p31-32 in families with premature CAD and MI. Journal of lipid research. 2008; 49(5):1034-8. NIHMSID: NIHMS81971 PMCID: PMC2311437
  121. Zhang S, Yin K, Ren X, Wang P, Zhang S, Cheng L, Yang J, Liu JY, Liu M, Wang QK. Identification of a novel KCNQ1 mutation associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long QT syndrome in a Chinese family. BMC medical genetics. 2008; 9:24. PMCID: PMC2322962
  122. Wu L, Yong SL, Fan C, Ni Y, Yoo S, Zhang T, Zhang X, Obejero-Paz CA, Rho HJ, Ke T, Szafranski P, Jones SW, Chen Q, Wang QK. Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav 1.5. The Journal of biological chemistry. 2008; 283(11):6968-78. PMID: 18184654
  123. Liu JY, Dai X, Sheng J, Cui X, Wang X, Jiang X, Tu X, Tang Z, Bai Y, Liu M, Wang QK. Identification and functional  characterization of a novel splicing mutation in RP gene PRPF31. Biochemical and biophysical research communications. 2008; 367(2):420-6. NIHMSID: NIHMS39558 PMCID: PMC2712755
  124. Ren X, Liu JY, Zhai LY, Yao Q, Dai X, Cai Z, Liu P, Sun K, Huang C, Wang QK, Liu M. A splicing mutation in the COL7A1 gene causes autosomal dominant dystrophic epidermolysis bullosa pruriginosa. The British journal of dermatology. 2008; 158(3):618-20. PMID: 18067480
  125. Shen GQ, Li L, Rao S, Abdullah KG, Ban JM, Lee BS, Park JE, Wang QK. Four SNPs on chromosome 9p21 in a South Korean population implicate a genetic locus that confers high cross-race risk for development of coronary artery disease. Arteriosclerosis, thrombosis, and vascular biology. 2008; 28(2):360-5. PMID: 18048766
  126. Gupta S, Young D, Maitra RK, Gupta A, Popovic ZB, Yong SL, Mahajan A, Wang Q, Sen S. Prevention of cardiac hypertrophy and heart failure by silencing of NF-kappaB. Journal of molecular biology. 2008; 375(3):637-49. NIHMSID: NIHMS38808 PMCID: PMC2277468
  127. Shen GQ, Rao S, Martinelli N, Li L, Olivieri O, Corrocher R, Abdullah KG, Hazen SL, Smith J, Barnard J, Plow EF, Girelli D, Wang QK. Association between four SNPs on chromosome 9p21 and myocardial infarction is replicated in an Italian population. Journal of human genetics. 2008; 53(2):144-50. PMID: 18066490
  128. Zhang S, Liu M, Dong JM, Yin K, Wang P, Bu J, Li J, Hao YS, Hao P, Wang QK, Wang L. Identification of a genetic locus for autosomal dominant infantile cataract on chromosome 20p12.1-p11.23 in a Chinese family. Molecular vision. 2008; 14:1893-7. PMCID: PMC2573730
  129. Shen GQ, Li L, Girelli D, Seidelmann SB, Rao S, Fan C, Park JE, Xi Q, Li J, Hu Y, Olivieri O, Marchant K, Barnard J, Corrocher R, Elston R, Cassano J, Henderson S, Hazen SL, Plow EF, Topol EJ, Wang QK. An LRP8 variant is associated with familial and premature coronary artery disease and myocardial infarction. American journal of human genetics. 2007; 81(4):780-91. PMCID: PMC2227927
  130. Chang W, Ding Q, Tang Z, Liu P, Jiang F, Ke T, Ren X, Wang Z, Liu J, Wang QK, Liu M. A novel de novo frameshift mutation of RPGR ORF15 is associated with X-linked retinitis pigmentosa in a Chinese family. Molecular vision. 2007; 13:1548-54. PMID: 17893654
  131. Zhang X, Chen L, Liu J, Zhao Z, Qu E, Wang X, Chang W, Xu C, Wang QK, Liu M. A novel DSPP mutation is associated with type II dentinogenesis imperfecta in a Chinese family. BMC medical genetics. 2007; 8:52. PMCID: PMC1995191
  132. Jane-wit D, Altuntas CZ, Johnson JM, Yong S, Wickley PJ, Clark P, Wang Q, Popović ZB, Penn MS, Damron DS, Perez DM, Tuohy VK. Beta 1-adrenergic receptor autoantibodies mediate dilated cardiomyopathy by agonistically inducing cardiomyocyte apoptosis. Circulation. 2007; 116(4):399-410. PMID: 17620508
  133. Wu L, Archacki SR, Zhang T, Wang QK. Induction of high STAT1 expression intransgenic mice with LQTS and heart failure. Biochemical and biophysical research communications. 2007; 358(2):449-54. NIHMSID: NIHMS24268 PMCID: PMC3505674
  134. Zhang T, Yong SL, Tian XL, Wang QK. Cardiac-specific overexpression of SCN5A gene leads to shorter P wave duration and PR interval in transgenic mice. Biochemical and biophysical research communications. 2007; 355(2):444-50. NIHMSID: NIHMS19385 PMCID: PMC1885482
  135. Tian XL, Cheng Y, Zhang T, Liao ML, Yong SL, Wang QK. Optical mapping of ventricular arrhythmias in LQTS mice with SCN5A mutation N1325S. Biochemical and biophysical research communications. 2007; 352(4):879-83. NIHMSID: NIHMS29776 PMCID: PMC2699586
  136. Yong SL, Ni Y, Zhang T, Tester DJ, Ackerman MJ, Wang QK. Characterization of the cardiac sodium channel SCN5A mutation, N1325S, in single murine ventricular myocytes. Biochemical and biophysical research communications. 2007; 352(2):378-83. NIHMSID: NIHMS15448 PMCID: PMC1773013
  137. Liu JY, Ren X, Yang X, Guo T, Yao Q, Li L, Dai X, Zhang M, Wang L, Liu M, Wang QK. Identification of a novel GPR143 mutation in a large Chinese family with congenital nystagmus as the most prominent and consistent manifestation. Journal of human genetics. 2007; 52(6):565-70. PMID: 17516023
  138. Topol EJ, Smith J, Plow EF, Wang QK. Genetic susceptibility to myocardial infarction and coronary artery disease. Human molecular genetics. 2006; 15 Spec No 2:R117-23. PMID: 16987874
  139. Wang X, Xiao F, Yang Q, Liang B, Tang Z, Jiang L, Zhu Q, Chang W, Jiang J, Jiang C, Ren X, Liu JY, Wang QK, Liu M. A novel mutation in GDF5 causes autosomal dominant symphalangism in two Chinese families. American journal of medical genetics. Part A. 2006; 140A(17):1846-53. PMID: 16892395
  140. Liu M, Ke T, Wang Z, Yang Q, Chang W, Jiang F, Tang Z, Li H, Ren X, Wang X, Wang T, Li Q, Yang J, Liu J, Wang QK. Identification of a CRYAB mutation associated with autosomal dominant posterior polar cataract in a Chinese family. Investigative ophthalmology & visual science. 2006; 47(8):3461-6. PMID: 16877416
  141. Ke T, Wang QK, Ji B, Wang X, Liu P, Zhang X, Tang Z, Ren X, Liu M. Novel HSF4 mutation causes congenital total white cataract in a Chinese family. American journal of ophthalmology. 2006; 142(2):298-303. PMID: 16876512
  142. Melamud A, Shen GQ, Chung D, Xi Q, Simpson E, Li L, Peachey NS, Zegarra H, Hagstrom SA, Wang QK, Traboulsi EI. Mapping a new genetic locus for X linked retinitis pigmentosa to Xq28. Journal of medical genetics. 2006; 43(6):e27. PMCID: PMC2593026
  143. Luo L, Shen GQ, Stiffler KA, Wang QK, Pretlow TG, Pretlow TP. Loss of heterozygosity in human aberrant crypt foci (ACF), a putative precursor of colon cancer. Carcinogenesis. 2006; 27(6):1153-9. PMID: 16474178
  144. Li X, Rao S, Jiang W, Li C, Xiao Y, Guo Z, Zhang Q, Wang L, Du L, Li J, Li L, Zhang T, Wang QK. Discovery of Time-Delayed Gene Regulatory Networks based on temporal gene expression profiling. BMC bioinformatics. 2006; 7:26. PMCID: PMC1386718
  145. Liu JY, Ji MF, Wang XR, Luo RL, Ren X, Liu M, Wang QK. Detection of human chromosomal abnormalities using a new technique combining 4',6-diamidino-2-phenyl-indole staining and image analysis. Clinical genetics. 2006; 69(1):65-71. PMID: 16451138

A complete list of Dr. Wang's publications may be viewed at PubMed.


05/06/2019 |  

New Causal Gene Implicated in Coronary Artery Disease

In a study recently published in the Journal of Biological Chemistry, Lerner researchers identified the specific causal gene associated with a chromosomal region (loci) long connected with risk for coronary artery disease (CAD), the most common cause of cardiovascular disease and the leading cause of death worldwide.