Enteroviral Cardiomyopathy: Bad News for the Dystrophin-Glycoprotein Complex

@article{Badorff2000EnteroviralCB,
  title={Enteroviral Cardiomyopathy: Bad News for the Dystrophin-Glycoprotein Complex},
  author={Cornel Badorff and Gil-Hwan Lee and Kirk U. Knowlton},
  journal={Herz},
  year={2000},
  volume={25},
  pages={227-232}
}
  • Cornel Badorff, Gil-Hwan Lee, Kirk U. Knowlton
  • Published 2000
  • Medicine
  • Herz
    • Genetic deficiency of the dystrophin-glycoprotein complex causes hereditary dilated cardiomyopathy. Enteroviruses can also cause cardiomyopathy and we have recently described a potential molecular mechanism for enterovirus-induced dilated cardiomyopathy. The coxsackieviral protease 2A proteolytically cleaves and functionally impairs dystrophin. Additionally, during infection with coxsackievirus B3, the dystrophin-glycoprotein complex becomes disrupted and the sarcolemmal integrity is lost.This… CONTINUE READING
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