About
Blog
Academy
Home
Menu

The Top 300 of 2021

Provided by the ClinCalc DrugStats Database

ClinCalc.com » Pharmacy » ClinCalc DrugStats » Top 300 Drugs

The Top 300 Drugs of 2021

Rank Drug Name Total Prescriptions (2018) Annual Change
1 Atorvastatin 112,474,023  1
2 Levothyroxine 105,773,990  1
3 Lisinopril 97,608,879  2
4 Metformin Hydrochloride 83,762,981 0
5 Amlodipine 75,811,947 0
6 Metoprolol 71,581,961 0
7 Albuterol 60,526,457  3
8 Omeprazole 58,364,556  1
9 Losartan Potassium 50,479,750 0
10 Simvastatin 48,007,043  2
11 Gabapentin 45,586,654 0
12 Acetaminophen; Hydrocodone Bitartrate 42,073,176  1
13 Hydrochlorothiazide 40,575,075  1
14 Sertraline Hydrochloride 38,383,042 0
15 Montelukast 35,222,630  1
16 Fluticasone 34,253,764  1
17 Amoxicillin 31,371,675  1
18 Furosemide 29,857,945  1
19 Pantoprazole Sodium 28,958,134 0
20 Acetaminophen 27,907,360  5
21 Prednisone 27,057,494  1
22 Escitalopram Oxalate 25,978,773  2
23 Fluoxetine Hydrochloride 25,619,277  8
24 Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate 25,331,775  3
25 Tramadol Hydrochloride 24,952,328  7
26 Insulin Glargine 24,911,721  7
27 Bupropion 24,488,843  4
28 Ibuprofen 24,453,501 0
29 Rosuvastatin 24,138,061  10
30 Pravastatin Sodium 24,022,031  6
31 Trazodone Hydrochloride 23,889,624  1
32 Tamsulosin Hydrochloride 23,254,004  3
33 Carvedilol 22,737,638  4
34 Meloxicam 22,610,690  4
35 Citalopram 22,224,263  9
36 Duloxetine 21,217,653  10
37 Alprazolam 20,843,479  16
38 Potassium 20,414,037  1
39 Clopidogrel Bisulfate 20,016,095  1
40 Aspirin 19,750,180  2
41 Ranitidine 18,739,686  7
42 Atenolol 18,644,884  6
43 Cyclobenzaprine 18,041,836 0
44 Glipizide 17,549,602  1
45 Methylphenidate 17,467,265  2
46 Azithromycin 17,102,628  11
47 Clonazepam 17,064,643  13
48 Oxycodone 16,967,479  4
49 Allopurinol 16,374,431  5
50 Venlafaxine 16,121,149  1
51 Hydrochlorothiazide; Lisinopril 15,932,877  7
52 Warfarin 14,772,355  1
53 Propranolol Hydrochloride 14,571,767  12
54 Hydrochlorothiazide; Losartan Potassium 13,880,262  13
55 Cetirizine 13,799,351  11
56 Estradiol 13,583,025  5
57 Ethinyl Estradiol; Norethindrone 13,509,602  4
58 Lorazepam 13,222,989  2
59 Quetiapine Fumarate 12,962,563  18
60 Zolpidem Tartrate 12,877,940  10
61 Ergocalciferol 12,831,209  6
62 Budesonide; Formoterol 12,339,319  13
63 Spironolactone 12,260,624  6
64 Ondansetron 12,240,225  19
65 Insulin Aspart 12,146,568  9
66 Apixaban 12,113,153  27
67 Naproxen 11,942,765  5
68 Lamotrigine 11,582,775  5
69 Fluticasone Propionate; Salmeterol Xinafoate 11,512,537  4
70 Pregabalin 11,429,654  3
71 Glimepiride 11,405,689  7
72 Diclofenac 11,372,069  22
73 Fenofibrate 11,325,402  3
74 Paroxetine 11,228,908  6
75 Clonidine 11,141,934  4
76 Loratadine 10,528,684  17
77 Diltiazem Hydrochloride 10,505,373  1
78 Hydroxyzine 10,431,206  21
79 Amitriptyline 10,282,767  8
80 Doxycycline 10,191,744  33
81 Ethinyl Estradiol; Norgestimate 10,166,878  19
82 Lisdexamfetamine Dimesylate 10,011,145  9
83 Sitagliptin Phosphate 9,813,527  12
84 Latanoprost 8,975,788  3
85 Cephalexin 8,938,064  17
86 Tizanidine 8,901,700  3
87 Finasteride 8,876,331  1
88 Lovastatin 8,769,143  4
89 Topiramate 8,648,513  11
90 Insulin Lispro 8,512,587  34
91 Sulfamethoxazole; Trimethoprim 8,448,278  30
92 Buspirone Hydrochloride 8,149,119  12
93 Oseltamivir Phosphate 8,139,836  66
94 Ferrous Sulfate 8,076,467  2
95 Amoxicillin; Clavulanate Potassium 7,974,978  21
96 Valsartan 7,694,037  11
97 Levetiracetam 7,666,166  13
98 Hydralazine Hydrochloride 7,545,026  7
99 Mirtazapine 7,504,257  20
100 Rivaroxaban 7,429,839  9
101 Aripiprazole 7,406,248  11
102 Oxybutynin 7,339,185  2
103 Esomeprazole 7,227,318  15
104 Alendronate Sodium 7,119,333  14
105 Folic Acid 7,099,659  9
106 Triamcinolone 6,848,479  3
107 Tiotropium 6,762,985  25
108 Thyroid 6,741,066  22
109 Ciprofloxacin 6,736,471  2
110 Isosorbide Mononitrate 6,698,824  1
111 Sumatriptan 6,674,685  14
112 Insulin Detemir 6,593,849  2
113 Benzonatate 6,493,593  35
114 Famotidine 6,470,718  1
115 Diazepam 6,448,085  20
116 Ropinirole Hydrochloride 6,224,574  8
117 Hydrochlorothiazide; Triamterene 6,007,404  16
118 Benazepril Hydrochloride 5,920,052  14
119 Metronidazole 5,852,534  61
120 Methocarbamol 5,849,167  58
121 Nifedipine 5,649,892  1
122 Baclofen 5,642,530  18
123 Methotrexate 5,518,246  6
124 Testosterone 5,483,791  8
125 Ezetimibe 5,476,606  26
126 Celecoxib 5,445,346  20
127 Guanfacine 5,429,776  4
128 Donepezil Hydrochloride 5,412,435  1
129 Hydroxychloroquine 5,406,190  1
130 Clindamycin 5,375,352  7
131 Divalproex Sodium 5,275,298  5
132 Morphine 5,225,088  23
133 Ethinyl Estradiol; Levonorgestrel 5,222,138  3
134 Prednisolone 5,202,600  5
135 Enalapril Maleate 5,182,854  13
136 Pioglitazone 5,178,776  11
137 Cyanocobalamin 5,107,466  33
138 Norethindrone 5,100,249  3
139 Meclizine Hydrochloride 4,960,255  22
140 Valacyclovir 4,931,639  12
141 Albuterol Sulfate; Ipratropium Bromide 4,789,978  31
142 Docusate 4,788,381  19
143 Liraglutide 4,771,233  20
144 Hydrocortisone 4,530,984  10
145 Verapamil Hydrochloride 4,492,362 0
146 Cefdinir 4,361,025  52
147 Nortriptyline Hydrochloride 4,346,899  36
148 Timolol 4,312,018  2
149 Dulaglutide 4,223,559  83
150 Promethazine Hydrochloride 4,171,551  3
151 Acyclovir 4,170,803  15
152 Fluconazole 4,115,042  30
153 Methylprednisolone 4,045,962  4
154 Metformin Hydrochloride; Sitagliptin Phosphate 3,991,205  15
155 Ramipril 3,989,667  21
156 Dexmethylphenidate Hydrochloride 3,961,348  33
157 Brimonidine Tartrate 3,929,927  10
158 Oxcarbazepine 3,915,508  49
159 Risperidone 3,909,621  3
160 Levofloxacin 3,892,600  5
161 Chlorthalidone 3,883,003  12
162 Atomoxetine Hydrochloride 3,848,913  37
163 Polyethylene Glycol 3350 3,829,568  1
164 Calcium; Cholecalciferol 3,824,225  72
165 Mupirocin 3,798,015  21
166 Ethinyl Estradiol; Etonogestrel 3,772,808  11
167 Drospirenone; Ethinyl Estradiol 3,759,495  69
168 Phentermine 3,683,239  42
169 Carbidopa; Levodopa 3,638,766  15
170 Omega-3-acid Ethyl Esters 3,635,260  12
171 Desogestrel; Ethinyl Estradiol 3,633,965  7
172 Guaifenesin 3,578,369  62
173 Rizatriptan Benzoate 3,490,815  31
174 Irbesartan 3,490,431  46
175 Progesterone 3,436,339  20
176 Doxazosin Mesylate 3,417,127  26
177 Linagliptin 3,390,520  23
178 Adalimumab 3,369,130  9
179 Nitrofurantoin 3,364,026  6
180 Budesonide 3,312,207  10
181 Amlodipine Besylate; Benazepril Hydrochloride 3,284,178  21
182 Hydrochlorothiazide; Valsartan 3,261,560  49
183 Digoxin 3,251,214  15
184 Acetaminophen; Butalbital 3,242,635  3
185 Insulin Degludec 3,226,387  80
186 Ketoconazole 3,222,574  33
187 Nitroglycerin 3,182,971  44
188 Temazepam 3,173,561  46
189 Amiodarone Hydrochloride 3,171,077  7
190 Memantine Hydrochloride 3,129,750  41
191 Canagliflozin 3,108,372  1
192 Ketorolac Tromethamine 3,085,293  79
193 Liothyronine Sodium 3,081,151  59
194 Lithium 3,077,611  14
195 Dicyclomine Hydrochloride 3,076,088  14
196 Pramipexole Dihydrochloride 2,984,633  17
197 Nebivolol Hydrochloride 2,955,158  53
198 Terazosin 2,954,414  4
199 Magnesium 2,940,781  28
200 Colchicine 2,925,875  1
201 Sucralfate 2,896,601  17
202 Medroxyprogesterone Acetate 2,866,848  20
203 Glyburide 2,841,093  29
204 Carbamazepine 2,840,744  28
205 Gemfibrozil 2,837,065  67
206 Nystatin 2,806,963  24
207 Sildenafil 2,782,913  10
208 Prazosin Hydrochloride 2,729,531  19
209 Beclomethasone 2,724,773  56
210 Linaclotide 2,697,352  47
211 Desvenlafaxine 2,690,813  24
212 Insulin Human; Insulin Isophane Human 2,689,053 0
213 Clobetasol Propionate 2,652,282  4
214 Empagliflozin 2,649,791  14
215 Lansoprazole 2,618,597  27
216 Erythromycin 2,552,822  1
217 Guaifenesin; Codeine Phosphate; Pseudoephedrine Hydrochloride 2,528,825 0
218 Bumetanide 2,468,002  59
219 Dexlansoprazole 2,464,913  17
220 Mometasone 2,464,820  23
221 Estrogens, Conjugated 2,436,386  15
222 Hydromorphone Hydrochloride 2,378,610  17
223 Letrozole 2,377,550  81
224 Olanzapine 2,354,778  15
225 Levocetirizine Dihydrochloride 2,348,311  50
226 Cyclosporine 2,323,787  22
227 Dapagliflozin 2,304,572  32
228 Labetalol 2,297,672  17
229 Anastrozole 2,292,337  29
230 Mesalamine 2,284,281  16
231 Sodium 2,269,422  6
232 Mirabegron 2,266,031  41
233 Lidocaine 2,225,382  25
234 Mycophenolate Mofetil 2,176,530  20
235 Ofloxacin 2,164,888  43
236 Indomethacin 2,160,197  55
237 Penicillin V 2,157,185  5
238 Metoclopramide Hydrochloride 2,087,258  15
239 Olmesartan Medoxomil 2,068,391  16
240 Azelastine Hydrochloride 2,047,699  57
241 Emtricitabine 2,045,343  17
242 Epinephrine 2,036,712  21
243 Ipratropium 2,023,254  27
244 Tamoxifen Citrate 2,009,016  7
245 Lurasidone Hydrochloride 2,006,353  29
246 Buprenorphine 1,984,590 0
247 Calcitriol 1,977,245  9
248 Ranolazine 1,971,575  25
249 Dorzolamide Hydrochloride; Timolol Maleate 1,950,346  16
250 Formoterol Fumarate; Mometasone Furoate 1,944,944  7
251 Betamethasone 1,920,813  69
252 Calcium 1,909,736  10
253 Tadalafil 1,893,022  29
254 Dextroamphetamine Sulfate 1,888,101 0
255 Methimazole 1,850,309  11
256 Umeclidinium Bromide; Vilanterol Trifenatate 1,821,792  56
257 Umeclidinium Bromide 1,814,589  67
258 Diphenhydramine Hydrochloride 1,805,034  17
259 Ticagrelor 1,793,510  66
260 Fexofenadine Hydrochloride 1,787,628  15
261 Sotalol Hydrochloride 1,770,181  6
262 Sodium Fluoride 1,758,373  15
263 Insulin Isophane 1,747,834 0
264 Solifenacin Succinate 1,736,710  19
265 Flecainide Acetate 1,731,229  24
266 Benztropine Mesylate 1,717,959  40
267 Eszopiclone 1,715,221  53
268 Polymyxin B Sulfate; Trimethoprim Sulfate 1,703,423  39
269 Phenytoin 1,643,497  48
270 Bromfenac Sodium; Prednisolone Acetate; Gatifloxacin 1,638,402 0
271 Torsemide 1,617,596  7
272 Sennosides 1,616,225  15
273 Tolterodine Tartrate 1,600,521  44
274 Bimatoprost 1,578,329  43
275 Etanercept 1,570,656  33
276 Travoprost 1,561,303  64
277 Minocycline Hydrochloride 1,556,983  40
278 Bisoprolol Fumarate; Hydrochlorothiazide 1,556,622  48
279 Nabumetone 1,554,892  35
280 Isotretinoin 1,531,101  63
281 Doxepin Hydrochloride 1,519,876  41
282 Primidone 1,437,305  44
283 Dexamethasone 1,417,570  38
284 Bisoprolol Fumarate 1,396,798  16
285 Exenatide 1,365,998  25
286 Chlorhexidine 1,361,682 0
287 Ethinyl Estradiol; Norgestrel 1,346,880  3
288 Dutasteride 1,337,420  12
289 Modafinil 1,325,982  38
290 Olopatadine 1,311,453  20
291 Fentanyl 1,296,490  41
292 Telmisartan 1,295,783  43
293 Polyethylene Glycol 3350 With Electrolytes 1,279,925  87
294 Tretinoin 1,264,213  1
295 Dexamethasone; Neomycin Sulfate; Polymyxin B Sulfate 1,261,712  73
296 Pseudoephedrine 1,255,713  62
297 Insulin Human 1,252,990  223
298 Sacubitril; Valsartan 1,249,668 0
299 Pancrelipase Lipase; Pancrelipase Protease; Pancrelipase Amylase 1,240,458  24
300 Brompheniramine Maleate; Dextromethorphan Hydrobromide; Pseudoephedrine Hydrochloride 1,228,852  19

Note: The data source (MEPS prescribed medicines file) is released annually by the U.S. Government. This data release represents survey data from two years prior. The ClinCalc DrugStats Database sanitizes and standardizes this data, and is typically released within a few months of the MEPS release. There is an inherent delay in collecting the survey data (eg, in the 2019 calendar year), MEPS releasing the data from patients (August 2021), and the ClinCalc DrugStats release (a few months later, classified as the 2022 drug list). Click here to read more about the process of creating the DrugStats database from the MEPS prescribed medicines file.

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2008-2018. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 21.1. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

Search

Related Links

Follow Us!

New and Popular

Loading...

Open Menu

Cite This Page

Show AMA citation

 
©2021 - ClinCalc LLC. All rights reserved.
Disclaimer - Privacy Policy - Contact Us
Updated Feb 11, 2017
Back to Top
Top