Annex III inventory

ECHA compiled an inventory of substances likely to meet the criteria of Annex III to the REACH Regulation. The aim is to support registrants in identifying whether reduced minimum information requirements or a full Annex VII information set is required.

The inventory was produced using publicly available databases with experimental data and by using (Q)SAR model results. Indications for hazardous toxicological or ecotoxicological properties together with information on uses and other available relevant information have to be compared with the criteria in Annex III.

The fact that a substance is not in this list does not necessarily mean that the criteria for Annex III are not met. Likewise, if a substance is on this inventory, a registrant can still benefit from the reduced information requirements if it is justified.

Note that the inventory is not a tool for classification, it only shows indications for concern. For instance, the fact that a substance is indicated as "Suspected mutagen" does not mean that ECHA considers it as a classified mutagen. All evidence should be taken into account before concluding on the need for classification.

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You can download the full Annex III inventory as XLS format.

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Annex III inventory [XLS] [EN]

Last updated 06 April 2021. Database contains 64899 unique substances/entries.

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Showing 1 - 50 of 64,899 results.

Name	EC / List no.	CAS no.	Criteria (indication)
''amyl nitrite'', mixed isomers	203-770-8	463-04-7	Harmonised classification for acute toxicity Suspected mutagen	Details
((4-Chloro-6-(2,3-xylidino)-2-pyrimidinyl)thio)acetic acid	621-657-5	50892-23-4	Suspected carcinogen Suspected mutagen	Details
((benzyloxy)carbonyl)-D-arginine	613-387-1	6382-93-0	Suspected carcinogen Suspected hazardous to the aquatic environment Suspected mutagen Suspected persistent in the environment Suspected skin sensitiser	Details
(+) Methyl-5-chloro-1,3-dihydro-2-hydroxy-1-oxo-2H-indene-2-carboxylate	604-399-8	144172-24-7	Suspected carcinogen Suspected hazardous to the aquatic environment Suspected persistent in the environment Suspected toxic for reproduction	Details
(+)-(1-methylpyrrolidin-2-yl)methyl bis(4-chlorophenoxy)acetate hydrochloride	252-643-3	35609-19-9	Suspected carcinogen Suspected hazardous to the aquatic environment Suspected persistent in the environment	Details
(+)-(1S)-Menthyl chloroformate	616-327-2	7635-54-3	Suspected carcinogen Suspected hazardous to the aquatic environment Suspected mutagen Suspected persistent in the environment Suspected skin sensitiser	Details
(+)-(1α,2β,5β)-2-(isopropyl)-5-methylcyclohexyl acetate	279-109-2	79199-84-1	Suspected hazardous to the aquatic environment Suspected skin sensitiser	Details
(+)-(R)-2-Methyl-1-butanol	612-181-9	616-16-0	Suspected acutely toxic via the oral route Suspected carcinogen Suspected hazardous to the aquatic environment Suspected toxic for reproduction	Details
(+)-1,2,3,4,4a,9-hexahydro-2-methyldibenzo[c,f]pyrimido[1,6-a]azepine fumarate	278-380-4	76134-84-4	Suspected hazardous to the aquatic environment Suspected mutagen Suspected persistent in the environment Suspected toxic for reproduction	Details
(+)-1,5,5-trimethyl-2-thiabicyclo[2.2.2]octane	242-949-5	19296-90-3	Suspected hazardous to the aquatic environment Suspected persistent in the environment Suspected toxic for reproduction	Details
(+)-1,5-dimethyl-1-vinylhex-4-enyl acetate	257-347-8	51685-40-6	Suspected hazardous to the aquatic environment Suspected persistent in the environment Suspected skin irritant Suspected skin sensitiser	Details
(+)-1,7,7-trimethyl-3-(phenylmethylene)bicyclo[2.2.1]heptan-2-one	252-856-1	36065-09-5	Suspected hazardous to the aquatic environment Suspected mutagen Suspected persistent in the environment Suspected skin sensitiser Suspected toxic for reproduction	Details
(+)-1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazolium nitrate	277-281-3	73094-38-9	Suspected bioaccumulative Suspected carcinogen Suspected hazardous to the aquatic environment Suspected persistent in the environment Suspected toxic for reproduction	Details
(+)-1-[o-(allyloxy)phenoxy]-3-(isopropylamino)propan-2-ol	245-357-5	22972-96-9	Suspected hazardous to the aquatic environment Suspected persistent in the environment Suspected toxic for reproduction	Details
(+)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-diyldiammonium maleate	278-614-5	77086-22-7	Suspected hazardous to the aquatic environment Suspected mutagen Suspected persistent in the environment Suspected toxic for reproduction	Details
(+)-2,3,4,6-tetrahydro-9-methoxy-1,2,5-trimethyl-1H-pyrido[4,3-b]carbazole	240-266-7	16101-11-4	Suspected carcinogen Suspected hazardous to the aquatic environment Suspected mutagen Suspected persistent in the environment Suspected toxic for reproduction	Details
(+)-2,3-dimethoxy-5-[(methylamino)sulphonyl]-N-[(1-methyl-2-pyrrolidinyl)methyl]benzamide	277-948-9	74651-66-4	Suspected hazardous to the aquatic environment Suspected mutagen Suspected persistent in the environment Suspected skin sensitiser Suspected toxic for reproduction	Details
(+)-2,6-diacetyl-1,7,9-trihydroxy-8,9b-dimethyldibenzofuran-3(9bH)-one, monosodium salt	308-170-0	97889-91-3	Suspected carcinogen Suspected hazardous to the aquatic environment Suspected persistent in the environment	Details
(+)-2-(2,2-dicyclohexylethyl)piperidine	254-559-2	39648-48-1	Suspected hazardous to the aquatic environment Suspected persistent in the environment Suspected skin irritant Suspected skin sensitiser	Details
(+)-2-[2-(3,5-dichloro-2-methoxyphenoxy)ethyl]-1-ethylpyrrolidine	279-343-5	79893-56-4	Suspected hazardous to the aquatic environment Suspected persistent in the environment Suspected skin sensitiser Suspected toxic for reproduction	Details
(+)-2-[2-(3,5-dichloro-2-methoxyphenoxy)ethyl]-1-ethylpyrrolidinium hydrochloride	279-340-9	79893-50-8	Suspected hazardous to the aquatic environment Suspected persistent in the environment Suspected skin sensitiser Suspected toxic for reproduction	Details
(+)-2-[4-[(isobut-2-enyl)amino]phenyl]propionic acid	275-648-2	71589-39-4	Suspected hazardous to the aquatic environment Suspected persistent in the environment Suspected skin sensitiser Suspected toxic for reproduction	Details
(+)-2-amino-1-butanol	227-475-9	5856-62-2	Suspected acutely toxic via the oral route Suspected hazardous to the aquatic environment Suspected toxic for reproduction	Details
(+)-2-chloropropiononitrile	274-982-6	70886-58-7	Suspected carcinogen Suspected hazardous to the aquatic environment Suspected mutagen Suspected persistent in the environment Suspected skin sensitiser Suspected toxic for reproduction	Details
(+)-2-ethylhexyl acetate	256-556-1	50373-28-9	Suspected carcinogen Suspected hazardous to the aquatic environment Suspected skin sensitiser	Details
(+)-3,7-dimethyloct-6-enyl propionate	301-827-2	94086-40-5	Suspected hazardous to the aquatic environment Suspected skin sensitiser	Details
(+)-3-(p-methoxyphenyl)-1-methylpropylamine	266-290-8	66264-86-6	Suspected hazardous to the aquatic environment Suspected persistent in the environment Suspected skin sensitiser	Details
(+)-3-[3-(tert-butylamino)-2-hydroxypropoxy]-4-morpholino-1,2,5-thiadiazole maleate	248-034-7	26839-77-0	Suspected hazardous to the aquatic environment Suspected mutagen Suspected persistent in the environment	Details
(+)-3-methyladipic acid	210-816-0	623-82-5	Suspected carcinogen Suspected hazardous to the aquatic environment Suspected skin sensitiser	Details
(+)-3-methylcyclohexanone	236-438-6	13368-65-5	Suspected hazardous to the aquatic environment Suspected skin sensitiser Suspected toxic for reproduction	Details
(+)-3-methylcyclopentanone	229-711-6	6672-30-6	Suspected skin sensitiser	Details
(+)-4'-(2-methylbutoxy)[1,1'-biphenyl]-4-carbonitrile	261-360-4	58600-86-5	Suspected bioaccumulative Suspected carcinogen Suspected hazardous to the aquatic environment Suspected mutagen Suspected persistent in the environment	Details
(+)-4-(2-methylbutyl)phenyl 4-(dodecyloxy)benzoate	281-075-9	83846-95-1	Suspected hazardous to the aquatic environment Suspected persistent in the environment Suspected skin sensitiser Suspected toxic for reproduction	Details
(+)-4-amino-5-(aminosulphonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide	298-764-5	93838-91-6	Suspected carcinogen Suspected hazardous to the aquatic environment Suspected mutagen Suspected persistent in the environment Suspected skin sensitiser	Details
(+)-4-amino-α-[(tert-butylamino)methyl]-3,5-dichlorobenzyl alcohol	256-608-3	50499-60-0	Suspected carcinogen Suspected hazardous to the aquatic environment Suspected mutagen Suspected persistent in the environment Suspected toxic for reproduction	Details
(+)-4-amino-α-[(tert-butylamino)methyl]-3,5-dichlorobenzyl alcohol hydrochloride	256-532-0	50310-83-3	Suspected carcinogen Suspected hazardous to the aquatic environment Suspected mutagen Suspected persistent in the environment Suspected toxic for reproduction	Details
(+)-4-Nitrobenzoic acid (2S)-glycidyl ester	623-349-6	115459-65-9	Suspected mutagen	Details
(+)-7-Ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin, monohydrochloride, trihydrate	603-967-2	136572-09-3	Suspected hazardous to the aquatic environment Suspected mutagen Suspected persistent in the environment Suspected skin sensitiser	Details
(+)-[(2-methylbutoxy)methyl]benzene	251-220-0	32793-78-5	Suspected carcinogen Suspected hazardous to the aquatic environment Suspected persistent in the environment Suspected skin sensitiser	Details
(+)-[2-[4-(benzoyloxy)-3-(methylthio)phenyl]-2-oxoethyl][3-(4-methoxyphenyl)-1-methylpropyl]ammonium bromide	266-292-9	66264-97-9	Suspected hazardous to the aquatic environment Suspected persistent in the environment Suspected skin sensitiser	Details
(+)-bornan-2-one	207-355-2	464-49-3	Suspected hazardous to the aquatic environment Suspected persistent in the environment Suspected skin sensitiser Suspected toxic for reproduction	Details
(+)-furfurylmethyl(α-methylphenethyl)ammonium cyclohexylsulphamate	223-232-6	3776-92-9	Suspected toxic for reproduction	Details
(+)-isomenthone	214-813-5	1196-31-2	Suspected hazardous to the aquatic environment Suspected mutagen Suspected persistent in the environment Suspected skin sensitiser Suspected toxic for reproduction	Details
(+)-menthone	222-227-6	3391-87-5	Suspected hazardous to the aquatic environment Suspected mutagen Suspected persistent in the environment Suspected skin sensitiser Suspected toxic for reproduction	Details
(+)-N-(3-ethoxypropyl)-2,4-dihydroxy-3,3-dimethylbutyramide	211-569-1	667-83-4	Suspected carcinogen Suspected persistent in the environment Suspected skin sensitiser	Details
(+)-N-(o-chlorobenzyl)-α-methylphenethylamine hydrochloride	227-434-5	5843-53-8	Suspected hazardous to the aquatic environment Suspected mutagen Suspected persistent in the environment Suspected toxic for reproduction	Details
(+)-N-[1-cyano-2-(4-hydroxy-3-methoxyphenyl)-1-methylethyl]acetamide	250-865-5	31915-71-6	Suspected carcinogen Suspected hazardous to the aquatic environment Suspected persistent in the environment	Details
(+)-N-Ethyl-N-methyl-3-[1 (dimethylamino)ethyl]phenylcarbamate tartrate acid	603-318-3	129101-54-8	Suspected hazardous to the aquatic environment Suspected mutagen Suspected persistent in the environment Suspected skin sensitiser Suspected toxic for reproduction	Details
(+)-N-Ethyl-N-methyl-3-[1-(dimethylamino)ethyl]phenylcarbamate	602-936-0	123441-03-2	Suspected hazardous to the aquatic environment Suspected mutagen Suspected persistent in the environment Suspected skin sensitiser Suspected toxic for reproduction	Details
(+)-neomenthol	218-691-4	2216-52-6	Suspected hazardous to the aquatic environment Suspected persistent in the environment Suspected skin sensitiser Suspected toxic for reproduction	Details

Showing 1 - 50 of 64,899 results.

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Annex III inventory

Annex III inventory

Annex III inventory

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Download the full Annex III Inventory

Last updated 06 April 2021. Database contains 64899 unique substances/entries.

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