Localization of function in anterior cingulate cortex: from psychosurgery to functional neuroimaging
- PMID: 23313645
- DOI: 10.1016/j.neubiorev.2013.01.002
Localization of function in anterior cingulate cortex: from psychosurgery to functional neuroimaging
Abstract
Early localizationists linked anterior cingulate cortex (ACC: Brodmann's area 24 and adjacent regions) with emotional behavior, paving the way for bilateral cingulotomy psychosurgery in severe, treatment resistant, cases of obsessive-compulsive disorder, chronic pain, depression, and substance abuse. Neuropsychological follow-up of such cases demonstrated executive function impairment. Abnormal neuroimaged activity in ACC has been found in many psychiatric conditions, including obsessive-compulsive disorder, chronic pain, substance abuse, and schizophrenia. With healthy participants, increased neuroimaged activity in ACC has been linked with challenging executive function tasks, homeostatically incongruous physical states, and the encoding of the pleasant/averseness of stimuli. There is disagreement on the cortical substrate subsumed by the term ACC, the existence of functionally distinct ACC subregions (e.g., dorsal: cognitive vs. ventral: emotion), and the interpretation of functional neuroimaging studies. Synthesis of neuropsychological and functional neuroimaging studies suggests ACC contributes to behavior by modifying responses especially in reaction to challenging cognitive and physical states that require additional effortful cognitive control. This is accomplished by monitoring the emotional salience of stimuli, exerting control over the autonomic nervous system, and modulating cognitive activity.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Similar articles
-
Neuroanatomical characteristics associated with response to dorsal anterior cingulotomy for obsessive-compulsive disorder.JAMA Psychiatry. 2015 Feb;72(2):127-35. doi: 10.1001/jamapsychiatry.2014.2216. JAMA Psychiatry. 2015. PMID: 25536384
-
Physiological responses to brain stimulation during limbic surgery: further evidence of anterior cingulate modulation of autonomic arousal.Biol Psychiatry. 2009 Oct 1;66(7):695-701. doi: 10.1016/j.biopsych.2009.05.009. Epub 2009 Jul 9. Biol Psychiatry. 2009. PMID: 19545859 Clinical Trial.
-
[The case of a patient with treatment-refractory obsessive-compulsive disorder operated by stereotactic bilateral cingulotomy].Neurol Neurochir Pol. 2004 Nov-Dec;38(6):519-23; discussion 524-5. Neurol Neurochir Pol. 2004. PMID: 15654678 Polish.
-
Dorsal anterior cingulotomy and anterior capsulotomy for severe, refractory obsessive-compulsive disorder: a systematic review of observational studies.J Neurosurg. 2016 Jan;124(1):77-89. doi: 10.3171/2015.1.JNS14681. Epub 2015 Aug 7. J Neurosurg. 2016. PMID: 26252455 Review.
-
[Psychosurgical treatment of malignant OCD: three case-reports].Encephale. 2003 Nov-Dec;29(6):545-52. Encephale. 2003. PMID: 15029089 Review. French.
Cited by
-
Parcellation-based tractographic modeling of the salience network through meta-analysis.Brain Behav. 2022 Jul;12(7):e2646. doi: 10.1002/brb3.2646. Epub 2022 Jun 22. Brain Behav. 2022. PMID: 35733239 Free PMC article.
-
Altered Intrinsic Brain Activity in Patients With Late-Life Depression: A Resting-State Functional MRI Study.Front Psychiatry. 2022 May 23;13:894646. doi: 10.3389/fpsyt.2022.894646. eCollection 2022. Front Psychiatry. 2022. PMID: 35677867 Free PMC article.
-
Examining Inhibitory Affective Processing Within the Rostral Anterior Cingulate Cortex Among Abstinent Cannabis-Using Adolescents and Young Adults.Front Psychiatry. 2022 Mar 28;13:851118. doi: 10.3389/fpsyt.2022.851118. eCollection 2022. Front Psychiatry. 2022. PMID: 35418882 Free PMC article.
-
Abnormal voxel-wise whole-brain functional connectivity in first-episode, drug-naïve adolescents with major depression disorder.Eur Child Adolesc Psychiatry. 2022 Mar 23. doi: 10.1007/s00787-022-01959-y. Online ahead of print. Eur Child Adolesc Psychiatry. 2022. PMID: 35318540
-
Brain Responses to Hypnotic Verbal Suggestions Predict Pain Modulation.Front Pain Res (Lausanne). 2021 Dec 23;2:757384. doi: 10.3389/fpain.2021.757384. eCollection 2021. Front Pain Res (Lausanne). 2021. PMID: 35295449 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources