Human understanding and unity with God is one of the topics that is very important in Hindu mysticism especially Vedanta school. Knowledge of man and his relationship with God is one of the issues that is of great importance in Hindu mysticism, especially the school of Vedanta and its mysticism, using the Hindu scriptures namely, Atman and Brahman in Vedanta school, we describe the agents of coming to God and the obstacles we will confront with them. Supreme or intuitive knowledge, self-knowledge and the use of old or guru precepts are among the common ways to connect with absolute truth. In addition, Shankara, the founder of Vedanta, emphasizes also the apparent or downward knowledge, ignorance or Avaydia, which is the effusion or illusion of the factors that cause the human being to leave the Lord and the seeker can achieve the connection with God by exploiting the factors and crossing the obstacles. The present study is a descriptive, explanatory type and the data have been analyzed and using content analysis method in a library method.