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Abstract
A discussion of the particulars leading to the eradication of smallpox is pertinent to both investigators and the public as the clamor for more “breakthroughs” intensifies. The rational allocation of biomedical research funds is increasingly threatened by disease-advocacy groups and congressional earmarking. An overly simplistic view of how advances truly occur promises only to stunt the growth of researchers and research areas not capable of immediate great breakthroughs. The authors review the contributions of Jenner and his countless predecessors to give a more accurate account of how “overnight medical breakthroughs” truly occur—through years of work conducted by many people, often across several continents.
In the public eye, few achievements are regarded with such excitement and awe as the medical breakthrough. Developments such as the discovery of penicillin and the eradication of polio and smallpox have each become a great story built around a singular hero. Edward Jenner, for example, is credited with discovering a means of safely conferring immunity to smallpox. The success of vaccination and subsequent eradication of this disease elevated Jenner to a status in medical history that is rivaled by few.
However, the story of the eradication of smallpox does not start or end with the work of Jenner. Men such as Benjamin Jesty and Reverend Cotton Mather as well as unnamed physicians from tenth century China to eighteenth century Turkey also made critical contributions to the crowning achievement. Inoculation to prevent smallpox was commonplace in Europe for generations prior to Jenner's work. Jenner himself was inoculated as a child. In fact, vaccination with cowpox matter was documented in England over 20 years prior to Jenner's work.
The authors' review of primary and secondary sources indicates that although Jenner's contribution was significant, it was only one of many. It is extremely rare that a single individual or experiment generates a quantum leap in understanding; this “lone genius” paradigm is potentially injurious to the research process. Wildly unrealistic expectations can only yield unsuccessful scientific investigation, but small steps by investigators supported by an informed public can build toward a giant leap, as the story of smallpox eradication clearly demonstrates.
References
- Smallpox and its eradication.in: World Health Organization, Geneva1988: 211-257
- The invisible fire.in: GP Putnam's Sons, New York1979: 41-121
- Vaccine development: necessity as the mother of invention.New Biologist. 1992; 4: 269-273
- The adoption of inoculation for smallpox in England.University of Pennsylvania, Philadelphia1957
- Small pox prevention during the Ming Dynasty.Koroth 6. 1972; 6: 96-99
- Early clinical pathologists: Edward Jenner (1749–1823).J Clin Pathol. 1992; 45: 756-758
- The great doctors: a biographical history of medicine.in: WW Norton and Company, New York1933: 258-264
- Inoculation for smallpox (variolation) as performed in England prior to Jenner's discovery.Pediatrics. 1972; 50: 889
- Vaccines and the power of immunity.Postgrad Med. 1997; 101: 154-168
- History and pathology of vaccination.Blakiston, Sun, and Company, Philadelphia1889
- The historic evolution of variolation.Bull Johns Hopk Hosp. 1913; 24: 69-84
- Medical discoveries by the non-medical.JAMA. 1903; 40: 1477-1489
- Gordon memorial lecture. Vaccines and vaccination: past, present, and future.Br Poult Sci. 1990; 31: 3-22
- The smallpox story: in words and pictures.University of Kansas, Kansas City1988
- Edward Jenner's cowpox vaccine: the history of a medical myth.Caliban Books, Great BritainmCaliban Books1977
- The history of health and the art of preserving of it.in: E Gordon, Edinburgh1760: 431-435
- Who discovered smallpox vaccination? Edward Jenner or Benjamin Jesty?.Trans Am Clin Climatol Assoc. 1979; 90: 44-55
- Remarks upon the introduction of inoculation for smallpox in England.Bull Hist Med. 1950; 24: 103-122
- Morris J. Morris R. Encyclopedia of American history. Harper Collins, New York1996
- Cotton Mather—the first significant figure in American medicine.Johns Hopkins University Press, Baltimore1954
- The influence of John Hunter's inoculation practice on Edward Jenner's discovery of vaccination against smallpox.J R Soc Med. 1993; 80: 266-267
- A letter to Doctor Zabdiel Boylston, occasioned by a Late Dissertation Concerning Inoculation.D. Henchman, London1729
- The practice and theory of inoculation with an account of its success.S. Austen, London1749
- A sermon against the dangerous and sinful practice of inoculation.Benjamin Indicott, Boston1730
- Looking at medical history: vaccination.Scott Med J. 1990; 35: 52-54
- Jenner's smallpox vaccine.Heinemann Educational Books, London1981
- Report from the committee on Dr. Jenner's petition, reflecting his discovery of vaccine inoculation.Parliament, House of Commons, Great Britain1802
- The evidence at large as laid before the committee of the House of Commons respecting Dr. Jenner's discovery of vaccine inoculation, together with the debate which followed, and some observations on the contravening evidence.J Murray and W Dwyer, London1805
- Classics in infectious diseases: Benjamin Waterhouse and the introduction of vaccination.Rev Infect Dis. 1987; 9: 1044-1052
- Magic shots: a human and scientific account of the long and continuing struggle to eradicate infectious diseases by vaccination.William Morrow and Company, New York1982
- Rider Haggard and smallpox.J R Soc Med. 1994; 77: 506-512
- Jenner's cowpox inoculation.BMJ. 1951; 2: 251-256
- The origins of vaccinia virus.J Infect Dis. 1977; 136: 453-455
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