Prefusion Coronavirus Spike Proteins and Their Use
Coronavirus S proteins mediate cellular attachment and membrane fusion and are therefore the target of protective antibodies. This technology employs protein engineering to stabilize the SARS-CoV-2 S in its prefusion conformation, preventing structural rearrangement, and exposing antigencally preferable surfaces. This technology is being utilized in approved SARS-CoV-2 vaccines as well as in diagnostic applications.
This technology is available for licensing for commercial development in accordance with 35 U.S.C. § 209 and 37 CFR Part 404..
- The stabilized prefusion SARS-CoV-2 spike protein can be used as a vaccine antigen to elicit robust neutralizing antibody responses. It is also useful in diagnostic applications and to isolate SARS-CoV-2 antibodies.
- Improved immunogenicity compared to other coronavirus S vaccine formulations.
- Increased protein expression, stability, and manufacturability compared to wild-type SARS-CoV-2 spike..