Effect of doxycycline on proliferation, MMP production, and adhesion in LAM-related cells.

@article{Chang2010EffectOD,
  title={Effect of doxycycline on proliferation, MMP production, and adhesion in LAM-related cells.},
  author={William Y. Chang and Debbie Clements and Simon R. Johnson},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2010},
  volume={299 3},
  pages={
          L393-400
        },
  url={https://api.semanticscholar.org/CorpusID:23947917}
}
Matrix metalloproteinases (MMPs) have been implicated in lung cyst formation in lymphangioleiomyomatosis (LAM). As doxycycline inhibits MMP activity in vivo, some patients take doxycycline, as one report has suggested a possible benefit in LAM. However, there have been no randomized controlled clinical trials of doxycycline for LAM, and any mechanism of action is unclear. Here, we examine previously proposed mechanisms of actions. Cell proliferation and adhesion were examined using 3-(4,5… 
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