Full Paper
Article first published online: 4 MAY 2011
DOI: 10.1002/asia.201000908
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
He, Y.-P., Tan, H., Arve, L., Baumann, S., Waldmann, H. and Arndt, H.-D. (2011), Biphenomycin B and Derivatives: Total Synthesis and Translation Inhibition. Chem. Asian J., 6: 1546–1556. doi: 10.1002/asia.201000908
Publication History
- Issue published online: 27 MAY 2011
- Article first published online: 4 MAY 2011
- Manuscript Received: 17 DEC 2010
Funded by
- Fonds der Chemischen Industrie
Chemistry Terms
Choose one or more boxes to highlight terms.
Keywords:
- antibiotics;
- cross couplings;
- natural products;
- peptides;
- synthesis design
Abstract
A full account on the synthesis of the antibiotic natural product biphenomycin B and several derivatives is reported, which employs a Suzuki coupling reaction of a free carboxylic acid and macrolactam formation as key transformations. Liberal exchange of the central amino acid was demonstrated. This procedure gave derivatives to study the influence of the polar side chain of the central amino acids on translation inhibition.
Featured Compounds
Compound 1 | |
---|---|
Molecular Weight: | 472.491 |
Molecular Formula: | C23H28N4O7 |
InChIKey: | Not Available |
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Compound 2 | |
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Molecular Weight: | 488.4904 |
Molecular Formula: | C23H28N4O8 |
InChIKey: | Not Available |
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Compound 3 | |
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Molecular Weight: | 731.7534 |
Molecular Formula: | C32H45N9O11 |
InChIKey: | Not Available |
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Compound 4 | |
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Molecular Weight: | Not Available |
Molecular Formula: | Not Available |
InChIKey: | Not Available |
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Compound 4a | |
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Molecular Weight: | 824.9594 |
Molecular Formula: | C42H60N6O11 |
InChIKey: | Not Available |
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Compound 4b | |
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Molecular Weight: | 869.957 |
Molecular Formula: | C42H59N7O13 |
InChIKey: | WFBZGMGSCAVZTQ-KUMHBBRUSA-N |
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Compound 5 | |
---|---|
Molecular Weight: | 344.5251 |
Molecular Formula: | C15H32N4O3Si |
InChIKey: | FTKCJQGBSAHMDE-NEPJUHHUSA-N |
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Compound 6 | |
---|---|
Molecular Weight: | 636.6888 |
Molecular Formula: | C34H40N2O10 |
InChIKey: | Not Available |
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Compound 7 | |
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Molecular Weight: | 455.2437 |
Molecular Formula: | C18H18INO5 |
InChIKey: | Not Available |
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Compound 8 | |
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Molecular Weight: | 435.319 |
Molecular Formula: | C22H34BNO7 |
InChIKey: | Not Available |
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Compound 9 | |
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Molecular Weight: | 321.1117 |
Molecular Formula: | C10H12INO3 |
InChIKey: | Not Available |
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Compound 10 | |
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Molecular Weight: | 326.957 |
Molecular Formula: | C8H8BrIO |
InChIKey: | Not Available |
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Compound 12 | |
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Molecular Weight: | 248.0179 |
Molecular Formula: | C7H5IO2 |
InChIKey: | Not Available |
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Compound 13 | |
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Molecular Weight: | 262.0445 |
Molecular Formula: | C8H7IO2 |
InChIKey: | Not Available |
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Compound 14 | |
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Molecular Weight: | 264.0603 |
Molecular Formula: | C8H9IO2 |
InChIKey: | Not Available |
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Compound 9.HCl | |
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Molecular Weight: | 357.573 |
Molecular Formula: | C10H13ClINO3 |
InChIKey: | NJEMVSDGMNYUQO-QRPNPIFTSA-N |
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Compound 11 | |
---|---|
Molecular Weight: | 295.3755 |
Molecular Formula: | C19H21NO2 |
InChIKey: | Not Available |
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Compound 15 | |
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Molecular Weight: | 371.599 |
Molecular Formula: | C11H15ClINO3 |
InChIKey: | Not Available |
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Compound S,S-16 | |
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Molecular Weight: | 482.3121 |
Molecular Formula: | C20H23IN2O4 |
InChIKey: | Not Available |
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Compound R,S-16 | |
---|---|
Molecular Weight: | 482.3121 |
Molecular Formula: | C20H23IN2O4 |
InChIKey: | Not Available |
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Compound R,R-16 | |
---|---|
Molecular Weight: | 482.3121 |
Molecular Formula: | C20H23IN2O4 |
InChIKey: | Not Available |
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Compound S,R-16 | |
---|---|
Molecular Weight: | 482.3121 |
Molecular Formula: | C20H23IN2O4 |
InChIKey: | Not Available |
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Compound 17 | |
---|---|
Molecular Weight: | 421.2275 |
Molecular Formula: | C15H20INO5 |
InChIKey: | Not Available |
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Compound 18 | |
---|---|
Molecular Weight: | 435.2541 |
Molecular Formula: | C16H22INO5 |
InChIKey: | Not Available |
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Compound 19 | |
---|---|
Molecular Weight: | 231.2457 |
Molecular Formula: | C10H17NO5 |
InChIKey: | Not Available |
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Compound 20 | |
---|---|
Molecular Weight: | 401.6129 |
Molecular Formula: | C20H39NO5Si |
InChIKey: | Not Available |
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Compound 21 | |
---|---|
Molecular Weight: | 415.5964 |
Molecular Formula: | C20H37NO6Si |
InChIKey: | Not Available |
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Compound 22 | |
---|---|
Molecular Weight: | 419.6281 |
Molecular Formula: | C20H41NO6Si |
InChIKey: | Not Available |
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Compound 23 | |
---|---|
Molecular Weight: | 444.6409 |
Molecular Formula: | C20H40N4O5Si |
InChIKey: | ZTGHBCLGLUZYPE-CABCVRRESA-N |
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Compound 24 | |
---|---|
Molecular Weight: | 963.1986 |
Molecular Formula: | C49H70N6O12Si |
InChIKey: | JFFWAYHWMAMFGJ-QRIZJJBVSA-N |
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Compound 25 | |
---|---|
Molecular Weight: | 788.9612 |
Molecular Formula: | C40H52N6O9Si |
InChIKey: | OHUICKBQLALQEP-GJBCSVNNSA-N |
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Compound 26 | |
---|---|
Molecular Weight: | 763.873 |
Molecular Formula: | C41H53N3O11 |
InChIKey: | Not Available |
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Compound 27 | |
---|---|
Molecular Weight: | 835.9787 |
Molecular Formula: | C45H61N3O12 |
InChIKey: | Not Available |
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Compound 28 | |
---|---|
Molecular Weight: | 941.0729 |
Molecular Formula: | C51H64N4O13 |
InChIKey: | Not Available |
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Compound 30 | |
---|---|
Molecular Weight: | 605.635 |
Molecular Formula: | C32H35N3O9 |
InChIKey: | Not Available |
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Compound 31 | |
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Molecular Weight: | 766.8354 |
Molecular Formula: | C42H46N4O10 |
InChIKey: | Not Available |
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Compound 32 | |
---|---|
Molecular Weight: | 413.4238 |
Molecular Formula: | C21H23N3O6 |
InChIKey: | Not Available |
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Compound 33 | |
---|---|
Molecular Weight: | 429.4232 |
Molecular Formula: | C21H23N3O7 |
InChIKey: | Not Available |
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Compound 34 | |
---|---|
Molecular Weight: | 456.4916 |
Molecular Formula: | C23H28N4O6 |
InChIKey: | Not Available |
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