UniProtKB - Q96IZ2 (ADTRP_HUMAN)
UniProt
Q96IZ2 - ADTRP_HUMAN
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Protein
Androgen-dependent TFPI-regulating protein
Gene
ADTRP
Organism
Homo sapiens (Human)
Status
Functioni
Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro).1 Publication
Names & Taxonomyi
Protein namesi | Recommended name: Androgen-dependent TFPI-regulating protein |
Gene namesi | Name:ADTRP Synonyms:C6orf105 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21214. ADTRP. |
Subcellular locationi
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: Colocalized with TFPI and CAV1 in lipid rafts.
Topology
Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
---|---|---|---|---|---|---|
Transmembranei | 4 – 24 | 21 | HelicalSequence analysis | Add BLAST | ||
Transmembranei | 47 – 67 | 21 | HelicalSequence analysis | Add BLAST | ||
Transmembranei | 86 – 106 | 21 | HelicalSequence analysis | Add BLAST | ||
Transmembranei | 120 – 140 | 21 | HelicalSequence analysis | Add BLAST | ||
Transmembranei | 155 – 175 | 21 | HelicalSequence analysis | Add BLAST | ||
Transmembranei | 190 – 210 | 21 | HelicalSequence analysis | Add BLAST |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
PharmGKBi | PA134981312. |
Polymorphism and mutation databases
BioMutai | ADTRP. |
DMDMi | 83286865. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
---|---|---|---|---|---|---|
Chaini | 1 – 230 | 230 | Androgen-dependent TFPI-regulating protein | PRO_0000190100 | Add BLAST |
Proteomic databases
PeptideAtlasi | Q96IZ2. |
PRIDEi | Q96IZ2. |
PTM databases
iPTMneti | Q96IZ2. |
PhosphoSitei | Q96IZ2. |
Expressioni
Tissue specificityi
Expressed in cultured endothelial cells and in placenta.1 Publication
Inductioni
By androgens.1 Publication
Gene expression databases
Bgeei | Q96IZ2. |
CleanExi | HS_C6orf105. |
ExpressionAtlasi | Q96IZ2. baseline and differential. |
Genevisiblei | Q96IZ2. HS. |
Organism-specific databases
HPAi | HPA048113. |
Interactioni
Protein-protein interaction databases
BioGridi | 124285. 3 interactions. |
IntActi | Q96IZ2. 3 interactions. |
Family & Domainsi
Sequence similaritiesi
Belongs to the AIG1 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
GeneTreei | ENSGT00390000012526. |
HOGENOMi | HOG000006895. |
HOVERGENi | HBG050468. |
InParanoidi | Q96IZ2. |
OMAi | HNYPSKK. |
PhylomeDBi | Q96IZ2. |
TreeFami | TF318170. |
Family and domain databases
InterProi | IPR006838. Far-17a_AIG1. [Graphical view] |
Pfami | PF04750. Far-17a_AIG1. 1 hit. [Graphical view] |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96IZ2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MTKTSTCIYH FLVLSWYTFL NYYISQEGKD EVKPKILANG ARWKYMTLLN
60 70 80 90 100
LLLQTIFYGV TCLDDVLKRT KGGKDIKFLT AFRDLLFTTL AFPVSTFVFL
110 120 130 140 150
AFWILFLYNR DLIYPKVLDT VIPVWLNHAM HTFIFPITLA EVVLRPHSYP
160 170 180 190 200
SKKTGLTLLA AASIAYISRI LWLYFETGTW VYPVFAKLSL LGLAAFFSLS
210 220 230
YVFIASIYLL GEKLNHWKWG DMRQPRKKRK
Natural variant
Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
---|---|---|---|---|---|---|
Natural varianti | 202 – 202 | 1 | V → I. Corresponds to variant rs2076185 [ dbSNP | Ensembl ]. | VAR_024365 |
Alternative sequence
Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
---|---|---|---|---|---|---|
Alternative sequencei | 52 – 52 | 1 | L → LKNRTAGFDIYQPGSFRQL in isoform 2. 1 Publication | VSP_041965 | ||
Alternative sequencei | 220 – 230 | 11 | GDMRQPRKKRK → VSVQILQRWRLESVGICFQW PDWKSPAKHQLVKNIR in isoform 3. Curated | VSP_042868 | Add BLAST |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK313114 mRNA. Translation: BAG35936.1. AK300919 mRNA. Translation: BAG62551.1. AL022724 Genomic DNA. Translation: CAB38130.1. AL022724 Genomic DNA. Translation: CAI20503.1. CH471087 Genomic DNA. Translation: EAW55304.1. CH471087 Genomic DNA. Translation: EAW55306.1. BC007011 mRNA. Translation: AAH07011.1. |
CCDSi | CCDS4521.1. [Q96IZ2-1] CCDS47374.1. [Q96IZ2-2] |
RefSeqi | NP_001137420.1. NM_001143948.1. [Q96IZ2-2] NP_116133.1. NM_032744.3. [Q96IZ2-1] XP_005249511.1. XM_005249454.2. [Q96IZ2-1] XP_011513258.1. XM_011514956.1. [Q96IZ2-3] |
UniGenei | Hs.126409. |
Genome annotation databases
Ensembli | ENST00000229583; ENSP00000229583; ENSG00000111863. [Q96IZ2-2] ENST00000414691; ENSP00000404416; ENSG00000111863. [Q96IZ2-1] |
GeneIDi | 84830. |
KEGGi | hsa:84830. |
UCSCi | uc003nab.4. human. [Q96IZ2-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismCross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK313114 mRNA. Translation: BAG35936.1. AK300919 mRNA. Translation: BAG62551.1. AL022724 Genomic DNA. Translation: CAB38130.1. AL022724 Genomic DNA. Translation: CAI20503.1. CH471087 Genomic DNA. Translation: EAW55304.1. CH471087 Genomic DNA. Translation: EAW55306.1. BC007011 mRNA. Translation: AAH07011.1. |
CCDSi | CCDS4521.1. [Q96IZ2-1] CCDS47374.1. [Q96IZ2-2] |
RefSeqi | NP_001137420.1. NM_001143948.1. [Q96IZ2-2] NP_116133.1. NM_032744.3. [Q96IZ2-1] XP_005249511.1. XM_005249454.2. [Q96IZ2-1] XP_011513258.1. XM_011514956.1. [Q96IZ2-3] |
UniGenei | Hs.126409. |
3D structure databases
ProteinModelPortali | Q96IZ2. |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 124285. 3 interactions. |
IntActi | Q96IZ2. 3 interactions. |
PTM databases
iPTMneti | Q96IZ2. |
PhosphoSitei | Q96IZ2. |
Polymorphism and mutation databases
BioMutai | ADTRP. |
DMDMi | 83286865. |
Proteomic databases
PeptideAtlasi | Q96IZ2. |
PRIDEi | Q96IZ2. |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000229583; ENSP00000229583; ENSG00000111863. [Q96IZ2-2] ENST00000414691; ENSP00000404416; ENSG00000111863. [Q96IZ2-1] |
GeneIDi | 84830. |
KEGGi | hsa:84830. |
UCSCi | uc003nab.4. human. [Q96IZ2-1] |
Organism-specific databases
CTDi | 84830. |
GeneCardsi | ADTRP. |
HGNCi | HGNC:21214. ADTRP. |
HPAi | HPA048113. |
MIMi | 614348. gene. |
neXtProti | NX_Q96IZ2. |
PharmGKBi | PA134981312. |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000012526. |
HOGENOMi | HOG000006895. |
HOVERGENi | HBG050468. |
InParanoidi | Q96IZ2. |
OMAi | HNYPSKK. |
PhylomeDBi | Q96IZ2. |
TreeFami | TF318170. |
Miscellaneous databases
GenomeRNAii | 84830. |
PROi | Q96IZ2. |
SOURCEi | Search... |
Gene expression databases
Bgeei | Q96IZ2. |
CleanExi | HS_C6orf105. |
ExpressionAtlasi | Q96IZ2. baseline and differential. |
Genevisiblei | Q96IZ2. HS. |
Family and domain databases
InterProi | IPR006838. Far-17a_AIG1. [Graphical view] |
Pfami | PF04750. Far-17a_AIG1. 1 hit. [Graphical view] |
ProtoNeti | Search... |
Publicationsi
- "Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).Tissue: Colon and Small intestine. - "The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. - Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. - "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).Tissue: Bone marrow. - "Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen."
Lupu C., Zhu H., Popescu N.I., Wren J.D., Lupu F.
Blood 118:4463-4471(2011) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INDUCTION.
Entry informationi
Entry namei | ADTRP_HUMAN | ||||||||
Accessioni | Q96IZ2Primary (citable) accession number: Q96IZ2 Secondary accession number(s): B2R7T9, B4DV39, Q5THW1 | ||||||||
Entry historyi |
| ||||||||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Annotation program | Chordata Protein Annotation Program | ||||||||
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 6Human chromosome 6: entries, gene names and cross-references to MIM
- Human entries with polymorphisms or disease mutationsList of human entries with polymorphisms or disease mutations
- Human polymorphisms and disease mutationsIndex of human polymorphisms and disease mutations
- MIM cross-referencesOnline Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
- SIMILARITY commentsIndex of protein domains and families
Similar proteinsi
Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:100% | UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry. |
90% | UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence). |
50% | UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster. |