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UniProtKB - Q9Y4K1 (CRBG1_HUMAN)

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Protein

Beta/gamma crystallin domain-containing protein 1

Gene

CRYBG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton.

GO - Molecular functioni

Complete GO annotation...

Keywordsi

LigandLectin

Protein family/group databases

CAZyiCBM13. Carbohydrate-Binding Module Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta/gamma crystallin domain-containing protein 1Imported
Alternative name(s):
Absent in melanoma 1 protein1 Publication
Gene namesi
Name:CRYBG1Imported
Synonyms:AIM11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:356. CRYBG1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi202.
MalaCardsiAIM1.
OpenTargetsiENSG00000112297.
PharmGKBiPA24649.

Polymorphism and mutation databases

BioMutaiAIM1.
DMDMi76800646.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000576091 – 1723Beta/gamma crystallin domain-containing protein 1Add BLAST1723

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei75PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Modified residuei329PhosphoserineCombined sources1
Modified residuei348PhosphoserineCombined sources1
Modified residuei484PhosphoserineCombined sources1
Modified residuei525PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y4K1.
PaxDbiQ9Y4K1.
PeptideAtlasiQ9Y4K1.
PRIDEiQ9Y4K1.

PTM databases

iPTMnetiQ9Y4K1.
PhosphoSitePlusiQ9Y4K1.
SwissPalmiQ9Y4K1.

Expressioni

Gene expression databases

BgeeiENSG00000112297.
CleanExiHS_AIM1.
ExpressionAtlasiQ9Y4K1. baseline and differential.
GenevisibleiQ9Y4K1. HS.

Organism-specific databases

HPAiCAB026378.
HPA030948.
HPA030949.

Interactioni

Protein-protein interaction databases

BioGridi106705. 13 interactors.
IntActiQ9Y4K1. 4 interactors.
STRINGi9606.ENSP00000358062.

Structurei

Secondary structure

11723
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1023 – 1028Combined sources6
Beta strandi1037 – 1039Combined sources3
Beta strandi1053 – 1069Combined sources17
Turni1070 – 1072Combined sources3
Beta strandi1073 – 1079Combined sources7
Beta strandi1081 – 1088Combined sources8
Helixi1094 – 1096Combined sources3
Beta strandi1098 – 1100Combined sources3
Beta strandi1112 – 1116Combined sources5
Beta strandi1416 – 1422Combined sources7
Turni1423 – 1425Combined sources3
Beta strandi1426 – 1434Combined sources9
Helixi1440 – 1442Combined sources3
Beta strandi1446 – 1460Combined sources15
Beta strandi1472 – 1477Combined sources6
Helixi1478 – 1481Combined sources4
Beta strandi1491 – 1495Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DADNMR-A1416-1495[»]
3CW3X-ray1.88A1022-1117[»]
ProteinModelPortaliQ9Y4K1.
SMRiQ9Y4K1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y4K1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1022 – 1061Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST40
Domaini1062 – 1117Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST56
Domaini1123 – 1163Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST41
Domaini1164 – 1206Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST43
Domaini1218 – 1270Beta/gamma crystallin 'Greek key' 5PROSITE-ProRule annotationAdd BLAST53
Domaini1271 – 1313Beta/gamma crystallin 'Greek key' 6PROSITE-ProRule annotationAdd BLAST43
Domaini1319 – 1361Beta/gamma crystallin 'Greek key' 7PROSITE-ProRule annotationAdd BLAST43
Domaini1362 – 1404Beta/gamma crystallin 'Greek key' 8PROSITE-ProRule annotationAdd BLAST43
Domaini1415 – 1452Beta/gamma crystallin 'Greek key' 9PROSITE-ProRule annotationAdd BLAST38
Domaini1453 – 1496Beta/gamma crystallin 'Greek key' 10PROSITE-ProRule annotationAdd BLAST44
Domaini1502 – 1542Beta/gamma crystallin 'Greek key' 11PROSITE-ProRule annotationAdd BLAST41
Domaini1543 – 1584Beta/gamma crystallin 'Greek key' 12PROSITE-ProRule annotationAdd BLAST42
Domaini1586 – 1719Ricin B-type lectinPROSITE-ProRule annotationAdd BLAST134

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IERF. Eukaryota.
ENOG4110BHM. LUCA.
GeneTreeiENSGT00670000097933.
HOGENOMiHOG000033870.
HOVERGENiHBG080825.
InParanoidiQ9Y4K1.
OrthoDBiEOG091G007H.
PhylomeDBiQ9Y4K1.
TreeFamiTF331078.

Family and domain databases

InterProiView protein in InterPro
IPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
IPR000772. Ricin_B_lectin.
PfamiView protein in Pfam
PF00030. Crystall. 6 hits.
PF00652. Ricin_B_lectin. 1 hit.
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiView protein in SMART
SM00458. RICIN. 1 hit.
SM00247. XTALbg. 6 hits.
SUPFAMiSSF49695. SSF49695. 3 hits.
SSF50370. SSF50370. 1 hit.
PROSITEiView protein in PROSITE
PS50915. CRYSTALLIN_BETA_GAMMA. 12 hits.
PS50231. RICIN_B_LECTIN. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y4K1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKRSSGRRS GRRRGSQKST DSPGADAELP ESAARDDAVF DDEVAPNAAS 
        60         70         80         90        100
DNASAEKKVK SPRAALDGGV ASAASPESKP SPGTKGQLRG ESDRSKQPPP 
       110        120        130        140        150
ASSPTKRKGR SRALEAVPAP PASGPRAPAK ESPPKRVPDP SPVTKGTAAE 
       160        170        180        190        200
SGEEAARAIP RELPVKSSSL LPEIKPEHKR GPLPNHFNGR AEGGRSRELG 
       210        220        230        240        250
RAAGAPGASD ADGLKPRNHF GVGRSTVTTK VTLPAKPKHV ELNLKTPKNL 
       260        270        280        290        300
DSLGNEHNPF SQPVHKGNTA TKISLFENKR TNSSPRHTDI RGQRNTPASS 
       310        320        330        340        350
KTFVGRAKLN LAKKAKEMEQ PEKKVMPNSP QNGVLVKETA IETKVTVSEE 
       360        370        380        390        400
EILPATRGMN GDSSENQALG PQPNQDDKAD VQTDAGCLSE PVASALIPVK 
       410        420        430        440        450
DHKLLEKEDS EAADSKSLVL ENVTDTAQDI PTTVDTKDLP PTAMPKPQHT 
       460        470        480        490        500
FSDSQSPAES SPGPSLSLSA PAPGDVPKDT CVQSPISSFP CTDLKVSENH 
       510        520        530        540        550
KGCVLPVSRQ NNEKMPLLEL GGETTPPLST ERSPEAVGSE CPSRVLVQVR 
       560        570        580        590        600
SFVLPVESTQ DVSSQVIPES SEVREVQLPT CHSNEPEVVS VASCAPPQEE 
       610        620        630        640        650
VLGNEHSHCT AELAAKSGPQ VIPPASEKTL PIQAQSQGSR TPLMAESSPT 
       660        670        680        690        700
NSPSSGNHLA TPQRPDQTVT NGQDSPASLL NISAGSDDSV FDSSSDMEKF 
       710        720        730        740        750
TEIIKQMDSA VCMPMKRKKA RMPNSPAPHF AMPPIHEDHL EKVFDPKVFT 
       760        770        780        790        800
FGLGKKKESQ PEMSPALHLM QNLDTKSKLR PKRASAEQSV LFKSLHTNTN 
       810        820        830        840        850
GNSEPLVMPE INDKENRDVT NGGIKRSRLE KSALFSSLLS SLPQDKIFSP 
       860        870        880        890        900
SVTSVNTMTT AFSTSQNGSL SQSSVSQPTT EGAPPCGLNK EQSNLLPDNS 
       910        920        930        940        950
LKVFNFNSSS TSHSSLKSPS HMEKYPQKEK TKEDLDSRSN LHLPETKFSE 
       960        970        980        990       1000
LSKLKNDDME KANHIESVIK SNLPNCANSD TDFMGLFKSS RYDPSISFSG 
      1010       1020       1030       1040       1050
MSLSDTMTLR GSVQNKLNPR PGKVVIYSEP DVSEKCIEVF SDIQDCSSWS 
      1060       1070       1080       1090       1100
LSPVILIKVV RGCWILYEQP NFEGHSIPLE EGELELSGLW GIEDILERHE 
      1110       1120       1130       1140       1150
EAESDKPVVI GSIRHVVQDY RVSHIDLFTE PEGLGILSSY FDDTEEMQGF 
      1160       1170       1180       1190       1200
GVMQKTCSMK VHWGTWLIYE EPGFQGVPFI LEPGEYPDLS FWDTEEAYIG 
      1210       1220       1230       1240       1250
SMRPLKMGGR KVEFPTDPKV VVYEKPFFEG KCVELETGMC SFVMEGGETE 
      1260       1270       1280       1290       1300
EATGDDHLPF TSVGSMKVLR GIWVAYEKPG FTGHQYLLEE GEYRDWKAWG 
      1310       1320       1330       1340       1350
GYNGELQSLR PILGDFSNAH MIMYSEKNFG SKGSSIDVLG IVANLKETGY 
      1360       1370       1380       1390       1400
GVKTQSINVL SGVWVAYENP DFTGEQYILD KGFYTSFEDW GGKNCKISSV 
      1410       1420       1430       1440       1450
QPICLDSFTG PRRRNQIHLF SEPQFQGHSQ SFEETTSQID DSFSTKSCRV 
      1460       1470       1480       1490       1500
SGGSWVVYDG ENFTGNQYVL EEGHYPCLSA MGCPPGATFK SLRFIDVEFS 
      1510       1520       1530       1540       1550
EPTIILFERE DFKGKKIELN AETVNLRSLG FNTQIRSVQV IGGIWVTYEY 
      1560       1570       1580       1590       1600
GSYRGRQFLL SPAEVPNWYE FSGCRQIGSL RPFVQKRIYF RLRNKATGLF 
      1610       1620       1630       1640       1650
MSTNGNLEDL KLLRIQVMED VGADDQIWIY QEGCIKCRIA EDCCLTIVGS 
      1660       1670       1680       1690       1700
LVTSGSKLGL ALDQNADSQF WSLKSDGRIY SKLKPNLVLD IKGGTQYDQN 
      1710       1720 
HIILNTVSKE KFTQVWEAMV LYT
Length:1,723
Mass (Da):188,676
Last modified:September 27, 2005 - v3
Checksum:iF4137765BCE039D5
GO
Isoform 2 (identifier: Q9Y4K1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MEKRSSGRRSGRRRGSQKSTDSPGAD → MQKPKTVAWENLGPEMSALGTAFSRE
     27-1207: Missing.

Note: No experimental confirmation available.
Show »
Length:542
Mass (Da):61,007
Checksum:i9FA2DAABFE123CCB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055687267G → D. Corresponds to variant dbSNP:rs11968933Ensembl.1
Natural variantiVAR_055688293Q → P1 PublicationCorresponds to variant dbSNP:rs1159148Ensembl.1
Natural variantiVAR_055689491C → R. Corresponds to variant dbSNP:rs3747787Ensembl.1
Natural variantiVAR_0556901096L → V. Corresponds to variant dbSNP:rs1350902Ensembl.1
Natural variantiVAR_0556911196E → A1 PublicationCorresponds to variant dbSNP:rs783396Ensembl.1
Natural variantiVAR_0556921395C → Y1 PublicationCorresponds to variant dbSNP:rs2297970Ensembl.1
Natural variantiVAR_0556931445T → S. Corresponds to variant dbSNP:rs1676015Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0565801 – 26MEKRS…SPGAD → MQKPKTVAWENLGPEMSALG TAFSRE in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_05658127 – 1207Missing in isoform 2. 1 PublicationAdd BLAST1181

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83116 Genomic DNA. Translation: AAB53792.1.
U83115 mRNA. Translation: AAB53791.1.
AK300443 mRNA. Translation: BAG62166.1.
AL390074, AL359292 Genomic DNA. Translation: CAH72091.1.
AL359292, AL390074 Genomic DNA. Translation: CAI21046.1.
CH471051 Genomic DNA. Translation: EAW48412.1.
CCDSiCCDS34506.1. [Q9Y4K1-1]
RefSeqiNP_001615.2. NM_001624.3. [Q9Y4K1-1]
UniGeneiHs.724262.
Hs.744905.

Genome annotation databases

EnsembliENST00000369066; ENSP00000358062; ENSG00000112297. [Q9Y4K1-1]
GeneIDi202.
KEGGihsa:202.
UCSCiuc003prh.4. human. [Q9Y4K1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCRBG1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4K1
Secondary accession number(s): B4DU04, O00296, Q5VWJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: September 27, 2005
Last modified: July 5, 2017
This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families