UniProtKB - Q8IY67 (RAVR1_HUMAN)
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Protein
Ribonucleoprotein PTB-binding 1
Gene
RAVER1
Organism
Homo sapiens (Human)
Status
Functioni
Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity).By similarity
GO - Molecular functioni
- nucleic acid binding Source: GO_Central
- RNA binding Source: UniProtKB
GO - Biological processi
- mRNA splicing, via spliceosome Source: GO_Central
Keywordsi
Molecular function | RNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Ribonucleoprotein PTB-binding 1Alternative name(s): Protein raver-1 |
Gene namesi | Name:RAVER1 Synonyms:KIAA1978 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30296. RAVER1. |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000161847. |
PharmGKBi | PA144596390. |
Polymorphism and mutation databases
BioMutai | RAVER1. |
DMDMi | 74759693. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000081487 | 2 – 606 | Ribonucleoprotein PTB-binding 1Add BLAST | 605 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | ||
Modified residuei | 6 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 14 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 463 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 474 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 562 | PhosphoserineBy similarity | 1 | ||
Isoform 2 (identifier: Q8IY67-2) | |||||
Modified residuei | 488 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 567 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q8IY67. |
MaxQBi | Q8IY67. |
PaxDbi | Q8IY67. |
PeptideAtlasi | Q8IY67. |
PRIDEi | Q8IY67. |
PTM databases
iPTMneti | Q8IY67. |
PhosphoSitePlusi | Q8IY67. |
Expressioni
Gene expression databases
CleanExi | HS_RAVER1. |
ExpressionAtlasi | Q8IY67. baseline and differential. |
Genevisiblei | Q8IY67. HS. |
Organism-specific databases
HPAi | HPA043575. HPA049457. |
Interactioni
Subunit structurei
Interacts with PTBP1, RAVER2, VCL and ACTN1. Part of a complex containing RAVER1, VCL and ACTN1 (By similarity).By similarity
Protein-protein interaction databases
BioGridi | 125936. 58 interactors. |
DIPi | DIP-46973N. |
IntActi | Q8IY67. 7 interactors. |
MINTi | MINT-2812331. |
STRINGi | 9606.ENSP00000293677. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 41 – 56 | Combined sources | 16 | |
Beta strandi | 60 – 64 | Combined sources | 5 | |
Helixi | 72 – 78 | Combined sources | 7 | |
Turni | 79 – 81 | Combined sources | 3 | |
Beta strandi | 84 – 90 | Combined sources | 7 | |
Turni | 91 – 94 | Combined sources | 4 | |
Beta strandi | 95 – 102 | Combined sources | 8 | |
Helixi | 103 – 113 | Combined sources | 11 | |
Beta strandi | 124 – 127 | Combined sources | 4 | |
Beta strandi | 133 – 138 | Combined sources | 6 | |
Helixi | 145 – 152 | Combined sources | 8 | |
Helixi | 153 – 155 | Combined sources | 3 | |
Beta strandi | 158 – 165 | Combined sources | 8 | |
Turni | 167 – 169 | Combined sources | 3 | |
Beta strandi | 172 – 182 | Combined sources | 11 | |
Helixi | 183 – 193 | Combined sources | 11 | |
Beta strandi | 204 – 207 | Combined sources | 4 | |
Helixi | 210 – 212 | Combined sources | 3 | |
Turni | 215 – 218 | Combined sources | 4 | |
Beta strandi | 221 – 226 | Combined sources | 6 | |
Helixi | 235 – 241 | Combined sources | 7 | |
Beta strandi | 244 – 246 | Combined sources | 3 | |
Beta strandi | 249 – 255 | Combined sources | 7 | |
Beta strandi | 261 – 268 | Combined sources | 8 | |
Helixi | 272 – 282 | Combined sources | 11 | |
Beta strandi | 293 – 296 | Combined sources | 4 | |
Beta strandi | 299 – 301 | Combined sources | 3 | |
Helixi | 303 – 313 | Combined sources | 11 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3H2U | X-ray | 2.75 | B/D | 39-321 | [»] | |
3H2V | X-ray | 2.90 | E/F/G/H | 59-130 | [»] | |
3SMZ | X-ray | 1.99 | A | 39-320 | [»] | |
3VF0 | X-ray | 2.54 | B | 39-321 | [»] | |
ProteinModelPortali | Q8IY67. | |||||
SMRi | Q8IY67. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8IY67. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 59 – 130 | RRM 1PROSITE-ProRule annotationAdd BLAST | 72 | |
Domaini | 132 – 210 | RRM 2PROSITE-ProRule annotationAdd BLAST | 79 | |
Domaini | 221 – 299 | RRM 3PROSITE-ProRule annotationAdd BLAST | 79 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 307 – 395 | Interaction with PTBP1By similarityAdd BLAST | 89 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 45 – 60 | Nuclear localization signalSequence analysisAdd BLAST | 16 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 406 – 468 | Pro-richAdd BLAST | 63 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG410IJBP. Eukaryota. ENOG410ZP6I. LUCA. |
GeneTreei | ENSGT00390000006046. |
HOGENOMi | HOG000253941. |
HOVERGENi | HBG059515. |
InParanoidi | Q8IY67. |
PhylomeDBi | Q8IY67. |
Family and domain databases
CDDi | cd12663. RRM1_RAVER1. 1 hit. |
InterProi | View protein in InterPro IPR034635. RAVER1. IPR034633. RAVER1_RRM1. IPR000504. RRM_dom. |
PANTHERi | PTHR23189:SF60. PTHR23189:SF60. 1 hit. |
Pfami | View protein in Pfam PF00076. RRM_1. 3 hits. |
SMARTi | View protein in SMART SM00360. RRM. 3 hits. |
SUPFAMi | SSF54928. SSF54928. 2 hits. |
PROSITEi | View protein in PROSITE PS50102. RRM. 2 hits. |
s (3)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8IY67-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MAADVSVTHR PPLSPKSGAE VEAGDAAERR APEEELPPLD PEEIRKRLEH
60 70 80 90 100
TERQFRNRRK ILIRGLPGDV TNQEVHDLLS DYELKYCFVD KYKGTAFVTL
110 120 130 140 150
LNGEQAEAAI NAFHQSRLRE RELSVQLQPT DALLCVANLP PSLTQQQFEE
160 170 180 190 200
LVRPFGSLER CFLVYSERTG QSKGYGFAEY MKKDSAARAK SDLLGKPLGP
210 220 230 240 250
RTLYVHWTDA GQLTPALLHS RCLCVDRLPP GFNDVDALCR ALSAVHSPTF
260 270 280 290 300
CQLACGQDGQ LKGFAVLEYE TAEMAEEAQQ QADGLSLGGS HLRVSFCAPG
310 320 330 340 350
PPGRSMLAAL IAAQATALNR GKGLLPEPNI LQLLNNLGPS ASLQLLLNPL
360 370 380 390 400
LHGSAGGKQG LLGAPPAMPL LNGPALSTAL LQLALQTQGQ KKPGILGDSP
410 420 430 440 450
LGALQPGAQP ANPLLGELPA GGGLPPELPP RRGKPPPLLP SVLGPAGGDR
460 470 480 490 500
EALGLGPPAA QLTPPPAPVG LRGSGLRGPL SHFYSGSPTS YFTSGLQAGL
510 520 530 540 550
KQSHLSKAIG SSPLGSGEGL LGLSPGPNGH SHLLKVRAGG GDMQGWEAPA
560 570 580 590 600
PQRPLTRPAL PSVSRPHWAA RNAALPTCCP RPSPAQKAAM WASTPRASAA
TTRTPT
Sequence cautioni
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040968 | 74 – 75 | EV → PS in isoform 3. 1 Publication | 2 | |
Alternative sequenceiVSP_040969 | 76 – 606 | Missing in isoform 3. 1 PublicationAdd BLAST | 531 | |
Alternative sequenceiVSP_017035 | 477 | R → RGLQKDSGPLPTPPGVSLLG EPPKDYRIPLNPYLNLHSLL PASNLAGKEARGWGGAGRSR RPAEGPLTNPPAPGGGSSSS KAFQLKSRLLSPLSSARLPP EPGLSDSYSFDYPSDMGPRR LFSHPREPALGPHGPSRHKM SPPPSGFGERSSGGSGG in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_017036 | 536 – 606 | VRAGG…TRTPT → TPLGGQKRSFAHLLPSPEPS PEGSYVGQHSQGLGGHYADS YLKRKRIF in isoform 2. 1 PublicationAdd BLAST | 71 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB075858 mRNA. Translation: BAB85564.1. Sequence problems. AC011511 Genomic DNA. No translation available. BC037428 mRNA. No translation available. BC037565 mRNA. Translation: AAH37565.1. Sequence problems. |
RefSeqi | NP_597709.2. NM_133452.2. |
UniGenei | Hs.744952. |
Genome annotation databases
Ensembli | ENST00000615032; ENSP00000479520; ENSG00000161847. [Q8IY67-1] |
GeneIDi | 125950. |
KEGGi | hsa:125950. |
UCSCi | uc060tgw.1. human. [Q8IY67-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:100% | UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry. |
90% | UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence). |
50% | UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster. |
Entry informationi
Entry namei | RAVR1_HUMAN | |
Accessioni | Q8IY67Primary (citable) accession number: Q8IY67 Secondary accession number(s): A6NMU4, Q8IY60, Q8TF24 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2006 |
Last sequence update: | March 1, 2003 | |
Last modified: | May 10, 2017 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references